Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: A bleed system including control circuitry and a variable jet pump. The control circuitry is configured to receive a signal indicative of a fluid parameter in the bleed system and cause the jet pump to alter a mixing ratio of a higher pressure gas and a lower pressure gas based on the signal. The jet pump is configured to combine the lower pressure gas and the higher pressure gas in the mixing ratio to generate a mixed gas. The jet pump is configured to supply the mixed gas to one or more gas loads in the bleed system. In examples, the control circuitry is configured to establish a system setpoint for the fluid parameter based on an operating status of the one or more gas loads.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: A laser is disclosed having a housing formed of a block of glass-ceramic. The block is machined (or otherwise formed) to define one or more channels that act as a waveguide in two dimensions for light within the laser resonator. The channels extend between cavities also formed within the block which retain optical components of the laser, e.g. one or more of the gain medium, cavity mirrors, intermediate reflectors etc. The positioning, shape and size of each cavity is bespoke for the optical component it holds in order that each optical component is retained in optical alignment rigidly against the sides of the cavity.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: A laser system having an optical ring resonator, a beam splitter that directs a first beam travelling in a first direction around the ring resonator, out of the resonator towards a reflector that reflects the first beam back into the resonator to travel in an opposite direction around the optical ring resonator that is in the same direction as a second beam travelling around the optical ring resonator; and a beam modifier configured and adapted to modify a spatial distribution of phase across an aperture of the first beam such as to cause it to become more similar or substantially match that of a spatial distribution of phase across an aperture of the second beam.

Abstract: A laser is disclosed having a housing formed of a block of glass-ceramic. The block is machined (or otherwise formed) to define one or more channels that act as a waveguide in two dimensions for light within the laser resonator. The channels extend between cavities also formed within the block which retain optical components of the laser, e.g. one or more of the gain medium, cavity mirrors, intermediate reflectors etc. The positioning, shape and size of each cavity is bespoke for the optical component it holds in order that each optical component is retained in optical alignment rigidly against the sides of the cavity.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: A camera for polarimetric, multispectral imaging is described. Such cameras are used in photonics, computational imaging and multispectral imaging in which both multispectral and polarimetric sensing modalities are used simultaneously for detection, recognition and identification. The camera enables multiple spectral images to be recorded simultaneously using polarizing beamsplitters and mirrors to divide the image according polarimetric and spectral bands. These multiple, polarized images are recorded on a single focal plane array (FPA) simultaneously. An image processor allows for the resolution of the subsequent image to be improved.

Abstract: A camera for polarimetric, multispectral imaging is described. Such cameras are used in photonics, computational imaging and multispectral imaging in which both multispectral and polarimetric sensing modalities are used simultaneously for detection, recognition and identification. The camera enables multiple spectral images to be recorded simultaneously using polarising beamsplitters and mirrors to divide the image according polarimetric and spectral bands. These multiple, polarised images are recorded on a single focal plane array (FPA) simultaneously. An image processor allows for the resolution of the subsequent image to be improved.

Abstract: A method and system for playing a video image including video frames and on-screen displays, and displaying an on-screen display associated with a video frame already played without interrupting the playing of the video frames. The displaying of the on-screen displays can be activated by the user commands received from a user. The user can select on-screen displays associated with frames of the video image played in a past pre-defined interval.

Abstract: A global program guide pause function in a broadcast multimedia system including a first main control configured to process multimedia content received from a packet processor, the first main control including an analyzer module for acquiring and analyzing program guide data to determine multiple time-delayed start content, a filtration module for filtering undesired content and enabling desired data streams to be saved in at least one global memory device, and a guide module for creating a program guide comprising only non-filtered programs being offered at time-delayed start times. The guide module is further configured to create multiple listings in the program guide showing a real-time versus a delayed-start time for each non-filtered program. A popular stream packet processor can be provided for saving data content corresponding to popular programs.

Abstract: A terminal sharing arrangement allows output terminals of an apparatus such as a television signal receiver or other device to be used for both outputting signals such as audio signals, and providing a diagnostic function. According to an exemplary embodiment, the apparatus includes a first terminal operative to output a first output signal during a first mode, and to receive a first diagnostic signal during a second mode. A second terminal is operative to output a second output signal during the first mode, and to output a second diagnostic signal during the second mode.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: Various embodiments of the present invention generally relate to systems and methods for identifying suspicious orders for controlled substances based on performing checks on a received order using historical information on previous orders. According to various embodiments, these checks may include: (1) comparing the order quantity for the received order with the order quantity history for the customer who placed the order for the controlled substance; (2) comparing the order quantity and the days since the last order was shipped to the customer for the same controlled substance with the order quantity history and the days between orders for the particular customer and controlled substance; (3) comparing the order quantity with order quantity history for orders received by customers of the same type for the controlled substance; and (4) comparing the order quantity with order quantity history for any customer for the particular controlled substance.

Abstract: A method and system for playing a video image including video frames and on-screen displays, and displaying an on-screen display associated with a video frame already played without interrupting the playing of the video frames. The displaying of the on-screen displays can be activated by the user commands received from a user. The user can select on-screen displays associated with frames of the video image played in a past pre-defined interval.

Abstract: A system for processing data stream content in a multi-channel broadcast multimedia system including a packet processor having an input control having a filter module for detecting at least one priority data stream from an input data stream, and an output control including a format module for displaying the priority data streams in real-time. The system can include an alarm detector for checking a rate of the priority data stream and issuing an alarm in the event of an alarm condition of the priority data stream.

Abstract: A notification system for satellite broadcasts is provided, the system comprising a database that is a depository for notification information, an encoder that encodes notification information from the database for satellite broadcasts, and a data linker that associates encoded notification information with at least one packet identifier (PID) for transmission to at least one satellite system transponder. Additionally, a receiver is described that can decode notification information from any multimedia content stream source utilizing a detector, a decoder and a notification information lookup.