Patents by Inventor Robert Lance Wells

Robert Lance Wells has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesizing vaccines, immunogens, and antibodies
    Patent number: 10421788
    Abstract: Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify glycosylation sites that that impact binding of antibodies to the immunogen, and modifying the glycan profiles on these glycosylation sites to synthesize novel immunogens, antibodies and vaccines. Then, the machine learning algorithm may output data relating to the glycosylation sites that are determinant or likely impact the binding affinity of the variants to the one or more antibodies.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 24, 2019
    Assignees: THE GENERAL HOSPITAL CORPORATION, UNIVERSITY OF GEORGIA RESEARCH FOUNDATION
    Inventors: Galit Alter, Robert Lance Wells, Wen-Han Yu
  • SYNTHESIZING VACCINES, IMMUNOGENS, AND ANTIBODIES
    Publication number: 20180282376
    Abstract: Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify glycosylation sites that that impact binding of antibodies to the immunogen, and modifying the glycan profiles on these glycosylation sites to synthesize novel immunogens, antibodies and vaccines. Then, the machine learning algorithm may output data relating to the glycosylation sites that are determinant or likely impact the binding affinity of the variants to the one or more antibodies.
    Type: Application
    Filed: September 9, 2016
    Publication date: October 4, 2018
    Applicants: THE GENERAL HOSPITAL CORPORATION, UNIVERSITY OF GEORGIA RESEARCH FOUNDATION
    Inventors: Galit ALTER, Robert Lance WELLS, Wen-Han YU
  • Vivo isotopic labeling method for quantitative glycomics
    Patent number: 9329169
    Abstract: The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 3, 2016
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC
    Inventors: Robert Lance Wells, Ronald C. Orlando, Stephen Dalton, Kelley W. Moremen, James Michael Pierce, James A. Atwood, III, Michael Tiemeyer, William S. York
  • GLYCOPEPTIDE AND USES THEREOF
    Publication number: 20120039984
    Abstract: A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.
    Type: Application
    Filed: July 2, 2009
    Publication date: February 16, 2012
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Geert-Jan Boons, Therese Buskas, Alex J. Harvey, Sampat Ingale, Margaretha Wolfert, Robert Lance Wells
  • VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS
    Publication number: 20100297609
    Abstract: The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
    Type: Application
    Filed: October 29, 2008
    Publication date: November 25, 2010
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Robert Lance Wells, Ronald C. Orlando, Stephen Dalton, Kelley W. Moreman, Michael J. Pierce, James A. Attwood, III, Michael Tiemeyer, William S. York