Patents by Inventor Robert Ledeen

Robert Ledeen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF PARKINSONS DISEASE WITH GLYCOLIPIDS
    Publication number: 20140187507
    Abstract: This invention provides compounds, compositions, and methods for treating Parkinson's disease. In particular, there is provided GM1 ganglioside analogs that are capable of penetrating the blood brain barrier and entering the cytoplasm of neurons. Endogenous GM1 interacts with the with GFR?1/RET, the GDNF receptor complex involved in GDNF signaling which is essential for neuron survival. In neurons that are deficient in endogenous GM1, the GM1 analog compounds of the invention are capable of restoring GDNF signaling thereby preventing neuron cell death.
    Type: Application
    Filed: December 16, 2013
    Publication date: July 3, 2014
    Inventors: Shawn DeFrees, Robert Ledeen, Gusheng Wu