Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Abstract: Provided are localized therapeutic delivery articles, comprising: a first fibrous layer comprising a first plurality of nanofibers; and a second fibrous layer comprising a second plurality of nanofibers, the first fibrous layer and the second fibrous layer being sealed to one another so as to define at least one sealed compartment therebetween, the article optionally comprising a first population of mechanically-responsive delivery particles configured to rupture upon exposure to a first rupture force, the first population of mechanically responsive delivery particles being disposed within at least one sealed compartment. The nanofibers can be aligned, which alignment allows the layers to emulate the structure of various body tissues, thereby affording control over cell growth on the articles. Also provided are methods of using and fabricating the disclosed articles.

Abstract: A composition, comprising: a hydrogel comprising crosslinked polymer chains, at least some of the crosslinked polymer chains having an agent coupled thereto. A method, comprising curing a precursor composition so as to give rise to a composition according to the present disclosure. A precursor composition, comprising: polymer chains bearing pendant groups; a crosslinker adapted to couple pendant groups to one another; and a functionalizer adapted to couple to a pendant group. A method, comprising curing a precursor composition according to the present disclosure so as to give rise to a composition, the composition optionally being a composition according to the present disclosure. A method, comprising: forming a hydrogel; and coupling the hydrogel to an agent, the coupling being effected by coupling (1) a pendant group borne by a polymer chain of the hydrogel and (2) a coupler associated with the agent.

Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Abstract: A composition, comprising: a plurality of mechanically-activated microcapsules; a mechanically-activated microcapsule defining a shell and an exterior surface; and the mechanically-activated microcapsule comprising one or more adhesion groups disposed Non the exterior surface of the mechanically-activated microcapsule, the one or more adhesion groups being configured to effect a covalent interaction, a non-covalent interaction, or both between the one or more adhesion groups and a matrix material, the covalent interaction, the non-covalent interaction, or both adhering the mechanically-activated microcapsule to the matrix material. Also provided are related methods and related articles.

Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Abstract: The present disclosure relates to modified polymers, compositions comprising the same, and methods for repairing damaged tissue in a subject, including cartilage tissue. The modified polymers, compositions comprising the same, and methods described comprise one or more tunable characteristics such that the modified polymers, compositions comprising the same, and methods form an integrated microenvironment comprising one or more of viable cells, a fibrous barrier, or a bioseal at a site of damaged tissue in a subject.