Abstract: A biocompatible hydrogel comprises a specified content of polyacrylamide and pyrogen-free water. Also disclosed is a method of making the hydrogel and an injectable or implantable endoprosthesis. The hydrogel may also be used to treat a cosmetic or functional defect. Hydrogels specified according to their polyacrylamide content may be used for medical indications, such as an implantable or injectable endoprostheses for mammoplastic reconstruction, implantable or injectable endoprostheses for treating (reflux) oesophagitis, and for body contouring of various body parts.

Abstract: A process which allows for the preparation of a substantially uniform hydrogel, such as a polyacrylamide hydrogel, wherein the uniformity of the hydrogel, in terms of the rheological properties, is established by limiting the temperature differential in the reaction process to a very narrow range, such as no more than 5° C. This process allows for polymers novel in their uniformity also by means of being suitably a continuous process. A continuous process for the preparation of a substantially uniform hydrogel, such as a polyacrylamide hydrogel, led to high uniformity by preventing unreacted monomers, such as acrylamide, from surpassing the gel front in the pipe reactor. This was achieved by use of a static mixer. Polymer hydrogels are rendered biocompatible by means of a novel washing process wherein the polymer specific surface area is appropriately set.

Abstract: A biocompatible hydrogel comprises a specified content of polyacrylamide and pyrogen-free water. Also disclosed is a method of making the hydrogel and an injectable or implantable endoprosthesis. The hydrogel may also be used to treat a cosmetic or functional defect. Hydrogels specified according to their polyacrylamide content may be used for medical indications, such as an implantable or injectable endoprostheses for mammoplastic reconstruction, implantable or injectable endoprostheses for treating (reflux) oesophagitis, and for body contouring of various body parts.