Patents by Inventor Robert Lloyd Binder

Robert Lloyd Binder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210038632
    Abstract: A method of treating vaginal atrophy is provided. The method comprises administering a vaginal care composition to vaginal tissue of a user experiencing a symptom of vaginal atrophy. The vaginal care composition may include an effective amount of a vaginal care agent selected to specifically treat symptoms of vaginal atrophy exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
  • Publication number: 20210038679
    Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
  • Patent number: 10563258
    Abstract: A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: February 18, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Kenton Duane Juhlin, Rosemarie Osborne, Scott Michael Hartman
  • Patent number: 10468120
    Abstract: A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: November 5, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
  • Patent number: 10418127
    Abstract: A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: September 17, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
  • Patent number: 10282514
    Abstract: A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: May 7, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
  • Patent number: 10072293
    Abstract: Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: September 11, 2018
    Assignee: The Procter and Gamble Company
    Inventors: Kevin John Mills, Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Ping Hu, Makio Tamura
  • Patent number: 10036741
    Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: July 31, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Kevin John Mills, Jun Xu, Robert Lloyd Binder, Robert Scott Youngquist, Deborah Ruth Finlay, Charles Carson Bascom
  • Patent number: 9920357
    Abstract: Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: March 20, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Robert Scott Youngquist, Jun Xu, Robert Lloyd Binder, Ping Hu, Teresa Dicolandrea, Thomas Larry Dawson, Brian Wilson Howard
  • Publication number: 20170343534
    Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.
    Type: Application
    Filed: August 14, 2013
    Publication date: November 30, 2017
    Applicant: The Procter & Gamble Company
    Inventors: Kevin John MILLS, Jun XU, Robert Lloyd BINDER, Robert Scott YOUNGQUIST, Deborah Ruth FINLAY, Charles Carson BASCOM
  • Patent number: 9434993
    Abstract: A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: September 6, 2016
    Assignee: The Procter & Gamble Company
    Inventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Kenton Duane Juhlin, Rosemarie Osborne, Scott Michael Hartman
  • Publication number: 20150322527
    Abstract: Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
    Type: Application
    Filed: July 16, 2015
    Publication date: November 12, 2015
    Inventors: Deborah Ruth FINLAY, Robert Lloyd BINDER, Michael Keith ROBINSON, Rosemarie OSBORNE
  • Publication number: 20150292018
    Abstract: A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Inventors: Robert Lloyd BINDER, Robert Scott YOUNGQUIST, Jun XU, Kenton Duane JUHLIN, Rosemarie OSBORNE, Scott Michael HARTMAN
  • Publication number: 20150292017
    Abstract: A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Inventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun XU, Kenton Duane JUHLIN, Rosemarie OSBORNE, Scott Michael HARTMAN
  • Patent number: 8986664
    Abstract: The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analog, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: March 24, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Teresa DiColandrea, Robert Scott Youngquist, Sancai Xie, Robert Lloyd Binder, Gary Richard Fuentes, Deborah Lade
  • Publication number: 20130331342
    Abstract: Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventors: Robert Scott Youngquist, Jun Xu, Robert Lloyd Binder, Ping Hu, Teresa Dicolandrea, Thomas Larry Dawson, Brian Wilson Howard
  • Publication number: 20130261006
    Abstract: A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: The Procter & Gamble Company
    Inventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU
  • Publication number: 20130261007
    Abstract: A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: The Procter & Gamble Company
    Inventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU
  • Publication number: 20130261024
    Abstract: A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: The Procter & Gamble Company
    Inventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU
  • Publication number: 20130259816
    Abstract: A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: The Procter & Gamble Company
    Inventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU