Abstract: An amphibious robot is provided. An aspect of the robot includes an elongated flexible body, actuators in the flexible body and spaced apart along a length of the flexible body. The actuators are configured to move the flexible body in a serpentine or concertina motion on land and in water. An additional aspect includes a camera coupled adjacent to an end of the flexible body, at least one sensor coupled to the flexible body, and a buoyancy controller located in the flexible body. Another aspect includes a power source coupled to the flexible body and configured to power the actuators, the camera, the sensors, and the buoyancy controller. Yet another aspect employs an electric controller to control the actuators and receive data from the sensors.

Abstract: Systems and methods are described to associate data from different nodes of a distributed ledger system. The nodes can generate transaction notifications, log data, and/or metrics data. At least some of the data generated by the nodes can be obtained by a data intake and query system via a distributed ledger system monitor. The data from the distributed ledger system can be stored in the data intake and query system and correlated. Based on an association between at least some of the data of the first node and at least some of the data of the second node, the data intake and query system can determine at least a partial history of a transaction in the distributed ledger system, relationships between components of the distributed ledger system, and/or an architecture of the distributed ledger system.

Abstract: Systems and methods are described to correlate different types of data obtained from a distributed ledger system. The distributed ledger system can generate transaction notifications, log data, and/or metrics data. At least some of the data generated by the distributed ledger system can be obtained by a data intake and query system via a distributed ledger system monitor. The data from the distributed ledger system can be stored in the data intake and query system and correlated. Based on the correlation, the data intake and query system can determine a history of a transaction in the distributed ledger system, relationships between components of the distributed ledger system, and/or an architecture of the distributed ledger system.

Abstract: Systems and methods are described to correlate different types of data obtained from a distributed ledger system. The distributed ledger system can generate transaction notifications, log data, and/or metrics data. At least some of the data generated by the distributed ledger system can be obtained by a data intake and query system via a distributed ledger system monitor. The data from the distributed ledger system can be stored in the data intake and query system and correlated. Based on the correlation, the data intake and query system can determine a history of a transaction in the distributed ledger system, relationships between components of the distributed ledger system, and/or an architecture of the distributed ledger system.

Abstract: Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylpiperazine class of ligands, improved D3 receptor affinity and selectivity, as well as water solubility, is achieved. A series of linking-chain derivatives are disclosed wherein functionality such as OH, OAc, and cis or trans-cyclopropyl groups have been introduced into the linking chain. In general, these modifications are well tolerated at D3 receptors and achieve high selectivity over D2 and D4 receptors.

Abstract: Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylpiperazine class of ligands, improved D3 receptor affinity and selectivity, as well as water solubility, is achieved. A series of linking-chain derivatives are disclosed wherein functionality such as OH or OAc groups have been introduced into the linking chain. In general, these modifications are well tolerated at D3 receptors and achieve high selectivity over D2 and D4 receptors.

Abstract: Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylpiperazine class of ligands, improved D3 receptor affinity and selectivity, as well as water solubility, is achieved. A series of linking-chain derivatives are disclosed wherein functionality such as OH or OAc groups have been introduced into the linking chain. In general, these modifications are well tolerated at D3 receptors and achieve high selectivity over D2 and D4 receptors.

Abstract: A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans —CH?CH—, —C?C—, or cyclohexyl. B is cis or trans —CH?CH— or absent. R1 represents an optionally substituted phenyl group, wherein said substituents are selected from the group consisting of: hydrogen, halogen, amino, nitro, hydroxyl, alkoxy, alkyl, acyl and pyridyl, and said substitution may occur at any of the ortho, meta, or para positions, or R1 represents a heteroaromatic ring. A preferred heteroaromatic ring is indole, quinoxoline, pyridyl, pyrimidyl, or imidazole. R2 and R3 may be independently hydrogen or a halogen, or R2 alone may be C1, C2, or C3 alkoxy, and m is 1 or 2, and n is 0, 1, or 2.