Abstract: An improved catalyst for cyclic olefin polymerization. The catalyst includes a transition metal carbene having the following structure: Mv(OR’)c*mX(v-c*m-2)=C(R*)2 wherein Mv is a Group 5 transition metal having a valence (v) of 5 or a Group 6 transition metal having a valence (v) of 5 or 6; each R? is independently a monovalent organic moiety comprising from 8 to 40 atoms selected from Groups 14-17; c is an integer from 1 to 3; m is ?, ½, 1, 3/2, 2, 3, or 4 and c*m ? v-2; X is a halogen; and each R* is independently H or a C1 to C7 alkyl. The catalyst is particularly useful for ring-opening metathesis polymerization (ROMP).

Abstract: The present disclosure relates to novel compounds of Formula (I) that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.

Abstract: The present disclosure relates to novel compounds that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.

Abstract: An embodiment of the present application provides a temperature adaptive control circuit for a light emitting diode and a lighting and/or signaling apparatus. The control circuit includes: a light emitting diode load circuit unit in which one or more light emitting diodes are connected; and a temperature adaptive circuit unit comprising a positive temperature coefficient thermistor and a negative temperature coefficient thermistor connected in series, wherein the temperature adaptive circuit unit is configured such that current flowing through the one or more light emitting diodes in the light emitting diode load circuit unit is a function of sum of resistance of the positive temperature coefficient thermistor and resistance of the negative temperature coefficient thermistor. It not only can compensate the variation of the luminescent intensity with the temperature in a desired working temperature for the LEDs, but also can achieve overheating protection for the LEDs to avoid damage thereof.

Abstract: The present invention provides edible compositions comprising a sweet taste modulator or bitter taste blocker of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.

Abstract: An embodiment of the present application provides a temperature adaptive control circuit for a light emitting diode and a lighting and/or signaling apparatus. The control circuit includes: a light emitting diode load circuit unit in which one or more light emitting diodes are connected; and a temperature adaptive circuit unit comprising a positive temperature coefficient thermistor and a negative temperature coefficient thermistor connected in series, wherein the temperature adaptive circuit unit is configured such that current flowing through the one or more light emitting diodes in the light emitting diode load circuit unit is a function of sum of resistance of the positive temperature coefficient thermistor and resistance of the negative temperature coefficient thermistor. It not only can compensate the variation of the luminescent intensity with the temperature in a desired working temperature for the LEDs, but also can achieve overheating protection for the LEDs to avoid damage thereof.

Abstract: Compounds of formula (I) including pharmaceutically acceptable salts, esters, solvates and stereoisomers thereof, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

Abstract: The invention includes the fitted quaternary structure of insulin receptor. It also includes methods of identifying compounds that modulate insulin receptor activity by producing a compound that interacts with all or part of the fitted quaternary structure of insulin receptor or a fragment or derivative thereof and which thereby modulates insulin receptor activity.