Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: The systems and methods provide a container assembly comprising: a container having a known storage capacity for storing a liquid; an additive dispensing assembly, the additive dispensing assembly dispensing variable, non-zero quantities of one or more additives into the liquid stored in the container; one or more vessels that each contain one of the additives, of the one or more additives, to be dispensed into the liquid; and a gas dispensing assembly, the gas dispensing assembly releasing a gas into the liquid stored in the container, and the gas dispensing assembly including: an onboard gas tank; a valve assembly; and a gas outlet, and the valve assembly controlling flow of gas from the onboard gas tank, through the valve assembly, and to the gas outlet so as to output the gas into the liquid; and wherein the valve assembly, to perform the controlling the flow of gas, is movable between: an open position, in which flow of gas is allowed to flow from the onboard gas tank to the gas outlet; and a closed posi

Abstract: The systems and methods provide a container assembly comprising: a container having a known storage capacity for storing a liquid; an additive dispensing assembly, the additive dispensing assembly dispensing variable, non-zero quantities of one or more additives into the liquid stored in the container; one or more vessels that each contain one of the additives, of the one or more additives, to be dispensed into the liquid; and a gas dispensing assembly, the gas dispensing assembly releasing a gas into the liquid stored in the container, and the gas dispensing assembly including: an onboard gas tank; a valve assembly; and a gas outlet, and the valve assembly controlling flow of gas from the onboard gas tank, through the valve assembly, and to the gas outlet so as to output the gas into the liquid; and wherein the valve assembly, to perform the controlling the flow of gas, is movable between: an open position, in which flow of gas is allowed to flow from the onboard gas tank to the gas outlet; and a closed posi

Abstract: The disclosure provides bottle apparatuses, pods or other storage containers to be used in bottle apparatuses, beverage dispensing apparatuses, and methods of making and using the same in accordance with principles of the disclosed subject matter. A bottle apparatus in accordance with the disclosure can include a neck portion; a bottle portion having an upper end and a lower end, the bottle portion defining an internal volume, and the neck portion attached to the upper end of the bottle portion; a base portion attached to the lower end of the bottle portion; a dispense assembly attached to the neck portion, and the dispense assembly providing for outflow of consumable liquid from the bottle portion; and a flow meter assembly disposed within the base portion, and the flow meter assembly monitoring an amount of the consumable liquid that flows out of the dispense assembly.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: The present disclosure relates to a pultrusion process for preparing a reinforced thermoset polyurethane composite, and specifically relates to a pultrusion process for simultaneous optimization of fiber sizing continuously along with the pultrusion process without any interruption by contacting the fibers with a sizing composition.

Abstract: Methods, systems, and media for obtaining weather data from around the world determining accurate long-range weather models is disclosed. Historic weather data may be collected from weather databases and a long-range weather model may be generated based on the historic weather data. Furthermore, more recent weather data indicative of weather from around the world may be collected from databases and sensors. Weather cycles indicative of repeating weather patterns may be predicted from the historic and the recent weather data and the long-range weather model may be updated to a predictive weather model based on the weather cycles and the recent weather data.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: This disclosure describes, in part, techniques for generating captions for audio content items. For instance, a system may store a user profile that is associated with audio content items. When a user associated with the user profile requests captions, the system may determine which audio content items have available captions and which audio content items do not have available captions. For the audio content items that do not have available captions, the system may determine priorities for the audio content items. The system may then cause the captions to be generated based on the priorities. When the captions are generated, the system may update statuses of the audio content items to indicate that the captions are available. The system may further store the captions in a database that is accessible to the user.