Abstract: A portable, self-contained beverage apparatus includes a container assembly having a known storage capacity for storing a consumable liquid, and a dispensing assembly disposed within the container assembly that dispenses variable, non-zero quantities of additives into the consumable liquid. The dispensing assembly includes multiple apertures structured and arranged to retain vessels containing the additives to be dispensed into the consumable liquid. The beverage apparatus also includes a level sensor disposed within the container assembly that determines a consumable liquid level of the consumable liquid stored in the container assembly. In certain embodiments, one or more positive displacement pumping mechanisms are configured to pump additive liquid from additive containers into a beverage chamber.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: The invention describes vaccine compositions containing particles having a polypeptide shell and a water-immiscible core. The polypeptide shell may comprise one or more pathogenic antigen proteins and/or one or more adjuvant polypeptides. Administration of the composition generates an immune response to the polypeptide contained in the shell. Adjuvant may be comprised in the water-immiscible core of the particle. The particles are therefore useful in methods of vaccination.

Abstract: The invention describes particles having a polypeptide shell. The polypeptide shell comprises at least one immunomodulatory polypeptide. Particles may be ultrasound-responsive particles, providing the ability to administer particles trandermally, or deliver particles to selected sites by use of ultrasound. Administration of the particles generates immunologic response to the polypeptide in the shell of the particle. The particles are therefore useful in methods of immunotherapy.

Abstract: A beverage apparatus, the beverage apparatus being hand-holdable by a user of the beverage apparatus to be portable, can include a beverage chamber housing that includes a chamber for storing a consumable liquid. The beverage apparatus can include a dispensing assembly that includes a receptacle. The receptacle can retain a vessel. The vessel can include an electronic tag and can contain an additive. The dispensing assembly can be operatively controllable by a controller to output the additive from the vessel into the consumable liquid. The beverage apparatus can include one or more sensors, devices, or assemblies that can be used to detect a volume of liquid in the chamber or a liquid level in the chamber. The beverage apparatus can include an apparatus computer processor portion (ACP) and an apparatus database portion.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: The present disclosure relates to a pultrusion process for preparing a reinforced thermoset polyurethane composite, and specifically relates to a pultrusion process for simultaneous optimization of fiber sizing continuously along with the pultrusion process without any interruption by contacting the fibers with a sizing composition.

Abstract: Methods, systems, and media for obtaining weather data from around the world determining accurate long-range weather models is disclosed. Historic weather data may be collected from weather databases and a long-range weather model may be generated based on the historic weather data. Furthermore, more recent weather data indicative of weather from around the world may be collected from databases and sensors. Weather cycles indicative of repeating weather patterns may be predicted from the historic and the recent weather data and the long-range weather model may be updated to a predictive weather model based on the weather cycles and the recent weather data.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: A method includes: accessing a corpus of emails sent from a email account prior to the initial time period; correlating sequences of words, in the corpus of emails, with language signals; aggregating the language signals into a sender model that represents combinations of language signals characteristic of language in emails sent from the email account; later, accessing a email outbound from the email account and directed to a recipient; scanning the email for the set of language signals; correlating sequences of words in the email with language signals; calculating a similarity score for the email based on the subset of language signals detected in the email and the sender model; and, in response to the similarity score falling below a threshold similarity, flagging the email as suspicious and redirecting the email away from the recipient.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: This disclosure describes, in part, techniques for generating captions for audio content items. For instance, a system may store a user profile that is associated with audio content items. When a user associated with the user profile requests captions, the system may determine which audio content items have available captions and which audio content items do not have available captions. For the audio content items that do not have available captions, the system may determine priorities for the audio content items. The system may then cause the captions to be generated based on the priorities. When the captions are generated, the system may update statuses of the audio content items to indicate that the captions are available. The system may further store the captions in a database that is accessible to the user.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: This disclosure describes, in part, techniques for providing captions with audio content. For instance, an electronic device may receive first data representing audio content and second data representing captions that are available for the audio content. The electronic device may then select portions of the captions for display while outputting the audio content. In some instances, the electronic device selects the portions using timestamps represented by the second data. For instance, the electronic device may select a portion of the captions such that the portion of the captions begins at a first pause within the audio content and/or ends at a second pause within the audio content. In some instances, the electronic device may also display graphical elements that indicate the current location within the captions.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia. Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.