Patents by Inventor Robert M. Abra

Robert M. Abra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomes containing an entrapped compound in supersaturated solution
    Patent number: 8062662
    Abstract: A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: November 22, 2011
    Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Danilo D. Lasic, Robert M. Abra, Yechezkel Barenholz, Tal Peleg-Shulman
  • Liposomes containing an entrapped compound in supersaturated solution
    Publication number: 20010033861
    Abstract: A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 25, 2001
    Inventors: Danilo D. Lasic, Robert M. Abra, Yechezkel Barenholz, Tal Peleg-Shulman
  • Liposomes containing a cisplatin compound
    Patent number: 6126966
    Abstract: A liposome composition containing an entrapped cisplatin compound is described. The liposomes have a surface coating of hydrophilic polymer chains on inner and outer surfaces and an entrapped cisplatin compound. The compound is entrapped with substantially greater retention in the liposomes, when compared to liposomes lacking the polymer coating. A method of preparing the composition is also described.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: October 3, 2000
    Assignee: Sequus Pharmaceuticals, Inc.
    Inventors: Robert M. Abra, Karen Reis
  • Liposomes containing a cisplatin compound
    Patent number: 5945122
    Abstract: A liposome composition containing an entrapped cisplatin compound is described. The liposomes have a surface coating of hydrophilic polymer chains on inner and outer surfaces and an entrapped cisplatin compound. The compound is entrapped with substantially greater retention in the liposomes, when compared to liposomes lacking the polymer coating. A method of preparing the composition is also described.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: August 31, 1999
    Assignee: Sequus Pharmaceuticals, Inc.
    Inventors: Robert M. Abra, Karen Reis
  • Liposome/bronchodilator method & System
    Patent number: 5340587
    Abstract: A method and system for treating bronchial constriction. The system includes a liposome composition containing a .beta..sub.2 -adrenoreceptor agonist in a liposome-entrapped form, and a device for aerosolizing a metered quantity of the composition. The drug in liposome aerosol form is substantially more effective in bronchodilation, over a substantially longer time, than the same amount of drug in free-drug aerosol form.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: August 23, 1994
    Assignee: Liposome Technology, Inc.
    Inventors: Paul J. Mihalko, Robert M. Abra, Ramachandran Radhakrishnan
  • Corticosteroid inhalation treatment method
    Patent number: 5192528
    Abstract: A method for delivering a therapeutic dosage of corticosteroid drug to the lungs, for treating a lung condition or disease. An aqueous suspension of sized liposomes containing the drug in liposome-entrapped form is aerosolized under conditions which produce aerosol particle sizes favoring particle deposition in a selected region of the respiratory tract, and the aerosol is administered in an amount which delivers the thereapeutic dosage level to the selected lung region.
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: March 9, 1993
    Assignee: Liposome Technology, Inc.
    Inventors: Ramachandran Radhakrishnan, Paul J. Mihalko, Robert M. Abra
  • Method and apparatus for administering dehydrated liposomes by inhalation
    Patent number: 4895719
    Abstract: A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air or propellant stream, or by release from a pressurized can containing a suspension of the liposomes in a fluorchlorocarbon solvent.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: January 23, 1990
    Assignee: Liposome Technology, Inc.
    Inventors: Ramachandran Radhakrishnan, Paul J. Mihalko, Robert M. Abra