Abstract: This disclosure is directed to nucleic acid and cell preservative compositions. Methods of preserving nucleic acids and/or cells in a blood or other biological sample, and kits for preserving nucleic acids and/or cells in a blood or other biological sample are also described.

Abstract: Examples described herein provide a computer-implemented method that includes receiving a list of objects with anomaly detection results associated therewith. The method further includes generating a resource graph, wherein the resource graph comprises at least two nodes, each of the at least two nodes being associated with one of the objects. The method further includes determining a relationship between the at least two nodes. The method further includes assigning an anomaly score to at least one of the objects. The method further includes calculating for at least one of the nodes, an overall anomaly score for the at least one of the nodes based on the anomaly score for the at least one of the objects and based on the anomaly score for another node related to the at least one of the nodes.

Abstract: Dynamic registration of software components for root cause of failure diagnosis may include determining a start of execution of a thread associated with a process, and creating a dynamic registry associated with the thread. One or more software components associated with execution of the thread are determined, and an entry in the dynamic registry is created for each of the one or more software components. The entry includes an identifier of the software component and a diagnostic content indicator associated with the software component. The diagnostic content indicator indicates component-specific diagnostic information associated with the software component.

Abstract: Examples described herein provide a computer-implemented method that includes defining a key performance indicator associated with a non-instrumented object of a processing system. The method further includes determining a current anomaly level of the key performance indicator for an instrumented object having a relationship with the non-instrumented object. The method further includes assigning an anomaly level to the non-instrumented object based on the current anomaly level.

Abstract: Systems and methods are described, which provides electrical stimulation to a person, while also facilitating delivery of a drug through the system to a target region of the brain. The electrical stimulation to the target region of the brain increases a permeability of a blood brain barrier.

Abstract: Examples described herein provide a computer-implemented method that includes detecting an anomaly associated with an object of a computer system and determining an importance classification of the object. An object relationship of the object is determined with respect to one or more other objects of the computer system. An impact score of the anomaly is determined based on the importance classification and the object relationship. An anomaly report is output with the impact score.

Abstract: Implantable therapeutic devices and methods for endovascular placement of devices at a target site, such an opening at a neck of an aneurysm, are disclosed. Selected embodiments of the present technology have closures that at least partially occlude the neck of an aneurysm to stabilize embolic or coagulative treatment of the aneurysm.

Abstract: A method, system, and computer program product are provided for performance anomaly detection. Velocity data is periodically received from a workload manager for one or more address spaces. An expected velocity value is created for each of the one or more address spaces. A factor of the expected velocity value is compared to a current velocity value from the velocity data. Based on the current velocity value being lower than the factor, a remedial action is generated indicating an anomaly.

Abstract: The present technology is directed generally to devices, systems, and methods for enclosing anatomical openings. In one example, an aneurysm device is endovascularly deliverable to a site proximate to an arterial aneurysm. The aneurysm device can include a closure structure having a distal-facing aspect configured to at least partially occlude the aneurysm and a proximal-facing aspect configured to arch over lumina of an artery. The closure structure can include a plurality of struts forming support arms and anchoring arms. The device further includes a supplemental stabilizer connected to the closure structure and configured to reside in the artery and press outward against a luminal wall thereof. A barrier can span at least a portion of the distal-facing aspect of the closure structure and be configured to further occlude a neck of the aneurysm. The closure structure can be configured to restrict and/or divert flow to or from the aneurysm.

Abstract: The present technology is directed generally to devices, systems, and methods for enclosing anatomical openings. In one example, an aneurysm device is endovascularly deliverable to a site proximate to an arterial aneurysm. The aneurysm device can include a closure structure having a distal-facing aspect configured to at least partially occlude the aneurysm and a proximal-facing aspect configured to arch over lumina of an artery. The closure structure can include a plurality of struts forming support arms and anchoring arms. The device further includes a supplemental stabilizer connected to the closure structure and configured to reside in the artery and press outward against a luminal wall thereof. A barrier can span at least a portion of the distal-facing aspect of the closure structure and be configured to further occlude a neck of the aneurysm. The closure structure can be configured to restrict and/or divert flow to or from the aneurysm.

Abstract: Examples described herein provide a computer-implemented method that includes defining a key performance indicator associated with a non-instrumented object of a processing system. The method further includes determining a current anomaly level of the key performance indicator for an instrumented object having a relationship with the non-instrumented object. The method further includes assigning an anomaly level to the non-instrumented object based on the current anomaly level.

Abstract: Examples described herein provide a computer-implemented method that includes receiving a list of objects with anomaly detection results associated therewith. The method further includes generating a resource graph, wherein the resource graph comprises at least two nodes, each of the at least two nodes being associated with one of the objects. The method further includes determining a relationship between the at least two nodes. The method further includes assigning an anomaly score to at least one of the objects. The method further includes calculating for at least one of the nodes, an overall anomaly score for the at least one of the nodes based on the anomaly score for the at least one of the objects and based on the anomaly score for another node related to the at least one of the nodes.

Abstract: Examples described herein provide a computer-implemented method that includes detecting an anomaly associated with an object of a computer system and determining an importance classification of the object. An object relationship of the object is determined with respect to one or more other objects of the computer system. An impact score of the anomaly is determined based on the importance classification and the object relationship. An anomaly report is output with the impact score.

Abstract: According to an aspect, a computer-implemented method includes configuring a disaster recovery computer system as a test environment of a mainframe computer system as a mirror image of a production environment, where the disaster recovery computer system is a backup of a primary production computer system. Test cases are executed in the test environment of the disaster recovery computer system. A stress and load impacts can be monitored on a plurality of computer system resources of the disaster recovery computer system based on execution of the test cases. The test environment can be disabled, and the disaster recovery computer system can be reconfigured as a production system based on a failure of the primary production computer system.

Abstract: According to an aspect, a computer-implemented method includes configuring a disaster recovery computer system as a test environment of a mainframe computer system as a mirror image of a production environment, where the disaster recovery computer system is a backup of a primary production computer system. Test cases are executed in the test environment of the disaster recovery computer system. A stress and load impacts can be monitored on a plurality of computer system resources of the disaster recovery computer system based on execution of the test cases. The test environment can be disabled, and the disaster recovery computer system can be reconfigured as a production system based on a failure of the primary production computer system.

Abstract: A method, system, and computer program product are provided for performance anomaly detection. Velocity data is periodically received from a workload manager for one or more address spaces. An expected velocity value is created for each of the one or more address spaces. A factor of the expected velocity value is compared to a current velocity value from the velocity data. Based on the current velocity value being lower than the factor, a remedial action is generated indicating an anomaly.

Abstract: Implantable devices for placement at a cavity or opening such as an aneurysm are disclosed. The implantable devices, in a deployed condition, have a generally inverted U-shaped profile with a curved or angled framework support structure sized and configured for placement in proximity to tissue surrounding the opening and anchoring legs extending proximally from the framework structure sized and configured to contact the wall of a neighboring lumen at opposed locations. Occlusive and semi-occlusive membranes may be associated with the framework support structure and deployed over the opening to provide exclusion of the opening and flow diversion. Proximal anchoring segments providing additional lumen wall surface area contact for the implantable device following deployment may be incorporated.

Abstract: Implantable devices for placement at a cavity or opening such as an aneurysm are disclosed. The implantable devices, in a deployed condition, have a generally inverted U-shaped profile with a curved or angled framework support structure sized and configured for placement in proximity to tissue surrounding the opening and anchoring legs extending proximally from the framework structure sized and configured to contact the wall of a neighboring lumen at opposed locations. Occlusive and semi-occlusive membranes may be associated with the framework support structure and deployed over the opening to provide exclusion of the opening and flow diversion. Proximal anchoring segments providing additional lumen wall surface area contact for the implantable device following deployment may be incorporated.

Abstract: The present technology is directed generally to devices, systems, and methods for enclosing anatomical openings. In one example, an aneurysm device is endovascularly deliverable to a site proximate to an arterial aneurysm. The aneurysm device comprises a closure structure having a distal-facing aspect configured to at least partially occlude the aneurysm and a proximal-facing aspect configured to arch over lumina of an artery. The closure structure can include a plurality of struts forming support arms and anchoring arms. The device further includes a supplemental stabilizer connected to the closure structure and configured to reside in the artery and press outward against a luminal wall thereof. A barrier can span at least a portion of the distal-facing aspect of the closure structure and be configured to further occlude a neck of the aneurysm. The closure structure can be configured to restrict and/or divert flow to or from the aneurysm.

Abstract: Implantable therapeutic devices and methods for endovascular placement of devices at a target site, such an opening at a neck of an aneurysm, are disclosed. Selected embodiments of the present technology have closures that at least partially occlude the neck of an aneurysm to stabilize embolic or coagulative treatment of the aneurysm.