Patents by Inventor Robert M. Berne

Robert M. Berne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
    Patent number: 4880783
    Abstract: The invention relates to an improved cardioplegic solution for reducing ischemic damage to the heart during operations and/or transplantation. The invented solution contains adenosine, hypoxanthine and ribose in addition to the electrolytes contained in standard cardioplegic solutions.
    Type: Grant
    Filed: September 29, 1988
    Date of Patent: November 14, 1989
    Assignee: University of Virginia Alumnia Patents Foundation
    Inventors: Robert M. Mentzer, Jr., Stephen W. Ely, Robert D. Lasley, Robert M. Berne
  • Adenosine in the treatment of supraventricular tachycardia
    Patent number: 4673563
    Abstract: A method of diagnosing and treating arrhythmias caused by re-entry in the A-V node by administering to a human or animal an effective amount of adenosine that restores normal sinus rhythm.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: June 16, 1987
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Robert M. Berne, Luiz Belardinelli, Rafael Rubio
  • Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
    Patent number: 4364922
    Abstract: A method of relieving atrioventricular conduction block by administering to a human or animal an effective amount of an adenosine antagonist that competitively inhibits adenosine or that reduces the level of adenosine present in myocardial tissue and associated fluids. A method of diagnosing atrioventricular conduction block caused by ischemia of the heart by measuring the time delay between atrial and ventricular excitation before and after the administration of an adenosine antagonist. Specific antagonists disclosed include methylxanthines.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: December 21, 1982
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Robert M. Berne, Luiz Belardinelli, Rafael Rubio