Patents by Inventor Robert M. Cothren
Robert M. Cothren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20160171165Abstract: An intelligent router for performing functions such as data aggregation from multiple sources, data mining, business intelligence analysis, exploratory data analysis, confirmatory data analysis, predictive data analysis, text analytics, and routing of the results to the appropriate recipient(s) at the appropriate time. The router may comprise an authorization/access manager, a business rules management system, routing engine, data aggregator, community data analytics engine.Type: ApplicationFiled: February 19, 2016Publication date: June 16, 2016Applicant: Cognosante Holdings, LLCInventors: Robert M. Cothren, Dale Will
-
Patent number: 8064670Abstract: Systems and methods are provided for analyzing a series of images. A contour initializer establishes a plurality of initial contours from respective images within the series of images. A model initializer interconnects the plurality of initial contours into a surface model. A model refiner refines the plurality of initial contours by manipulating the surface model.Type: GrantFiled: September 29, 2004Date of Patent: November 22, 2011Assignee: Northrop Grumman Systems CorporationInventors: Brent E. Higgs, John S. Birbeck, Cliff E. Frieler, Robert M. Cothren
-
Publication number: 20040101184Abstract: An automated method and system for autocontouring organs and other anatomical structures in CT and other medical images employs one or more contouring techniques, depending on the particular organs or structures to be contoured. In a preferred embodiment, an edge-based technique is employed to contour one or more organs. A multiple hypothesis testing technique can be employed to improve the accuracy of the resulting contour. Independent algorithms can be employed for contouring multiple organ in a given region, such as the male pelvic region. An integration algorithm can be employed to combine the results of the independent algorithms to improve accuracy further.Type: ApplicationFiled: November 26, 2002Publication date: May 27, 2004Inventors: Radhika Sivaramakrishna, John S. Birbeck, Cliff E. Frieler, Robert M. Cothren
-
Publication number: 20020045811Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: ApplicationFiled: June 2, 1995Publication date: April 18, 2002Inventors: CARTER KITTRELL, ROBERT M. COTHREN, MICHAEL S. FELD
-
Patent number: 6154560Abstract: A system and method for automatically staging regional lymph nodes under the TNM classification system using textural analyses of endoscopic ultrasound images. N stage for a lymph node is determined by analyzing the organization of the texture of a region corresponding to the node on a digitized ultrasound image. Specifically, Haralick's difference entropy and correlation textural features are calculated and compared to predetermined reference values to predict whether the lymph node is benign or malignant. Also, the cross-sectional area of the node is determined and used to make an N staging determination. An application of the present invention is staging of esophageal lymph nodes in the diagnosis and treatment of esophageal carcinoma using endoscopic ultrasound images.Type: GrantFiled: August 30, 1996Date of Patent: November 28, 2000Assignee: The Cleveland Clinic FoundationInventors: Robert M. Cothren, Alexandre Purper Brandao, Gregory Zuccaro, Jr.
-
Patent number: 5693043Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: April 3, 1990Date of Patent: December 2, 1997Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5562100Abstract: A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed through a catheter using an array of optical fiber. The fluorescence spectrum of the tissue can be displayed and analyzed to obtain information regarding the chemical composition and medical condition of the tissue inside the human body.Type: GrantFiled: May 25, 1994Date of Patent: October 8, 1996Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Michael S. Feld, Joseph J. Baraga, Kyungwon An, Rebecca Richards-Kortum, Richard P. Rava, Young D. Park, Anand V. Mehta, Paola Taroni, Lucene Tong, Ramachandra R. Dasari
-
Patent number: 5496305Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: January 29, 1992Date of Patent: March 5, 1996Assignee: Massachusetts Institue of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5419323Abstract: A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed through a catheter using an array of optical fiber. The fluorescence spectrum of the tissue can be displayed and analyzed to obtain information regarding the chemical composition and medical condition of the tissue inside the human body.Type: GrantFiled: August 29, 1991Date of Patent: May 30, 1995Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Michael S. Feld, Joseph J. Baraga, Kyungwon An, Rebecca Richards-Kortum, Richard P. Rava, Young D. Park, Anand Mehta, Paola Taroni, Lucene Tong, Ramachandra R. Dasari
-
Patent number: 5318024Abstract: A laser endoscope is disclosed for generating a spectrally resolved spatial image of tissue. Fiber optics positioned within an optically shielded endoscope are used to deliver laser radiation to tissue to be imaged. Radiation returning through the fiber optics from the tissue is spectrally resolved and used to generate an image of tissue that can assist in diagnosis and treatment.Type: GrantFiled: December 16, 1991Date of Patent: June 7, 1994Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5304173Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: July 20, 1993Date of Patent: April 19, 1994Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5290275Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: July 16, 1991Date of Patent: March 1, 1994Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld, Barry Sachs
-
Patent number: 5199431Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: October 4, 1989Date of Patent: April 6, 1993Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5125404Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically displacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: November 21, 1989Date of Patent: June 30, 1992Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5106387Abstract: A method of diagnosis of the type of tissue in an artery, including distinguishing artery wall from atheromateous plaque is described, in which a catheter with one or more optical fibers is enclosed at a distal end by an optical shield transparent to light radiation and wherein the proximal end of the catheter and optical fibers are coupled to a source of optical radiation. The catheter is inserted into an artery until the optical shield is brought into contact with a suspected arterial lesion or other tissue to be diagnosed.Type: GrantFiled: September 21, 1989Date of Patent: April 21, 1992Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5104392Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: October 11, 1989Date of Patent: April 14, 1992Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 5034010Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: September 22, 1989Date of Patent: July 23, 1991Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 4913142Abstract: A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically displacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.Type: GrantFiled: May 26, 1987Date of Patent: April 3, 1990Assignee: Massachusetts Institute of TechnologyInventors: Carter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
-
Patent number: 4669467Abstract: A mode mixer is described for mixing themodes of optical fibers in a laser catheter adapted to be inserted in arteries for treatment of arterial tissue or obstructions. The mode mixer creates microbends in the fibers by physically deforming the fibers, such as by mechanically pressing the fibers against a rigid member to adjust the spot size of light exiting the fibers.Type: GrantFiled: March 22, 1985Date of Patent: June 2, 1987Assignee: Massachusetts Institute of TechnologyInventors: Robert L. Willett, Robert M. Cothren, Jr., Carter Kittrell, Michael S. Feld