Patents by Inventor Robert M. Crowl

Robert M. Crowl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6077935
    Abstract: An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: June 20, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Crowl, Robert C. Gallo, E. Prem Reddy, George M. Shaw, Flossie Wong-Staal
  • Patent number: 5869233
    Abstract: An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: February 9, 1999
    Inventors: Robert M. Crowl, Robert C. Gallo, E. Prem Reddy, George M. Shaw, Flossie Wong-Staal
  • Patent number: 5773210
    Abstract: An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: June 30, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Crowl, Robert C. Gallo, E. Prem Reddy, George M. Shaw, Flossie Wong-Staal
  • Patent number: 4925784
    Abstract: Methods and compositions are provided for the cloning and expression of plasmids bearing genes encoding a novel protein derived from HTLV-III. This protein, which is called the gag/env protein and which contains antigenic determinants from both the core and envelope proteins of HTLV-III, can be purified to homogeneity and used as the basis for diagnostic tests to detect the presence of antibodies against viruses associated with AIDS or the viruses themselves in human sera and other biological fluids. The gag/env protein may also be formulated for use as a vaccine for protection against AIDS through prophylactic immunization.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: May 15, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert M. Crowl, Daru Young
  • Patent number: 4728609
    Abstract: Th preparation of a double-stranded polydeoxy ribonucleotide having cohesive termini each comprising one strand of a double-strand restriction endonuclease recognition site and, between the termini, a structural gene coating for the expression of recombinant growth hormone releasing factor, at least a majority of the codons and the coding strand of said gene being codons preferred for the expression of microbial genomes; a method of producing such DNA a recombinant microbial cloning vehicle comprising such DNA and the novel methods of producing said peptide are described.
    Type: Grant
    Filed: September 24, 1985
    Date of Patent: March 1, 1988
    Assignee: Hoffmann-La-Roche Inc.
    Inventors: Ram S. Bhatt, Kenneth J. Collier, Robert M. Crowl, Mohindar S. Poonian
  • Patent number: 4582800
    Abstract: Improved vectors and methods for regulating the expression in bacteria of a eucaryotic anti-viral protein, such as mature human immune interferon, the gene for which has been cloned onto a bacterial plasmid, is disclosed. The improved vectors incorporate and method utilizes transcriptional regulatory elements derived from bacteriophage lambda and ribosome binding sites either derived from bacteriophage lambda and/or synthesized chemically.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: April 15, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Robert M. Crowl