Abstract: Disclosed is the use of a combination of histone deacetylase inhibitors and kinase inhibitors with anti-EGFR activity.

Abstract: Disclosed is the identification, provision and use of biomarkers predictive of sensitivity or resistance to EGFR inhibitors such as gefitinib and products and processes related thereto. Specifically, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for the detection of the copy number or expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described.

Abstract: Disclosed is the use of a combination of histone deacetylase inhibitors and epidermal growth factor receptor (EGFR) inhibitors to treat cancer.

Abstract: Disclosed is the use of a combination of histone deacetylase inhibitors and kinase inhibitors with anti-EGFR activity.

Abstract: The present invention provides the sequence for a novel gene called TRC8 which is located on chromosome 8. Various types of alterations in the gene have been shown to be associated with renal and thyroid tumors. One such alteration involves a 3;8 translocation which interrupts TRC8 and results in a fusion with the 3p14 gene, FHIT. Another alteration includes a mutation in the 5′ untranslated region of TRC8. Thus, the invention further provides sequences corresponding to the gene fusions created during the translocation, as well as the sequence of the gene containing the mutation in the 5′ region. The invention further provides methods for detecting alterations in TRC8 which have potential utility in the diagnosis of tumors.

Abstract: The present invention provides the sequence for a novel gene called TRC8 which is located on chromosome 8. Various types of alterations in the gene have been shown to be associated with renal and thyroid tumors. One such alteration involves a 3;8 translocation which interrupts TRC8 and results in a fusion with the 3p14 gene, FHIT. Another alteration includes a mutation in the 5′ untranslated region of TRC8. Thus, the invention further provides sequences corresponding to the gene fusions created during the translocation, as well as the sequence of the gene containing the mutation in the 5′ region. The invention further provides methods for detecting alterations in TRC8 which have potential utility in the diagnosis of tumors.

Abstract: Mannich bases, prepared using a phenol substituted with a medium length branched alkyl chain, the alkyl being derived from a 1-olefin oligomer. These Mannich bases act as friction-reducing agents in lubricant and liquid fuel compositions.

Abstract: A borated oxazoline monoester, made by reacting a boron compound with the product of reaction between tris(hydroxymethyl)aminomethane and carboxylic acid is a new composition of matter. It is useful in a lubricating oil for reducing friction, and, therefore, fuel consumption in an internal combustion engine.

Abstract: Reaction products of N-alkylalkylenediamine with organic acids are disclosed.

Abstract: Mercaptothiadiazole adducts of unsaturated esters such as jojoba oil or pentaerythritol tetraoleate are highly effective multifunctional friction reducing and copper strip passivating additives for various lubricants.

Abstract: Amides of certain ether diamines are provided. These compounds give excellent results when tested in lubricants as friction reducing additives.

Abstract: Lubricant and fuel compositions having unique fuel saving properties are obtained by adding to the lubricant or fuel a product made by reacting a boron compound with a mixture of vicinal diols and long chain alcohols or hydroxyl-containing carboxylate esters.

Abstract: Lubricant and fuel compositions having unique fuel saving properties are obtained by adding to the lubricant or fuel a product made by reacting a boron compound with a mixture of vicinal diols and long chain alcohols or hydroxyl-containing carboxylate esters.

Abstract: High quality synthetic lubricating oils are provided when certain olefinic monomers such as ethylene, propylene and a third 1-olefin are copolymerized and thereafter dewaxed by means of a urea adduction process.

Abstract: Reaction products from thiodephenol, aldehydes and amines are effective friction reducing additives in lubricants.

Abstract: Reaction products from certain phenol, aldehydes and amines are effective friction reducing additives in lubricants and in liquid fuels, such as gasoline and alcohol fuels.

Abstract: Dimercaptothiadiazole adducts of hydroxyl-containing unsaturated compounds and their borated analogues provide effective multifunctional friction reducing and corrosion inhibiting properties to various lubricating fluids when incorporated therein.

Abstract: Boration of an oxazoline of the formula ##STR1## where R is defined hereinbelow provides a new composition of matter which, when added to a lubricating oil, will reduce friction and decrease fuel consumption in an internal combustion engine.

Abstract: Metal salts of hydrocarbyl oxazoline phosphorodithioic acids are novel compounds effective for reducing friction and wear when added to a lubricant.

Abstract: Phosphosulfurized hydrocarbyl oxazoline reacted with nitrogen-containing compounds and certain olefins are novel compounds effective for reducing friction and wear when added to a lubricant.