Abstract: This disclosure provides transgenic plants having enhanced traits such as increased yield, enhanced nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Abstract: This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency, and enhanced drought tolerance or water use efficiency. Transgenic plants may include field crops as well as plant propagules and progeny of such transgenic plants. Methods of making and using such transgenic plants are also provided. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed, and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Abstract: An apparatus and corresponding method are provided for treating or preventing at least one of brain, brain-stem and associated nervous tissue injuries in a mammal suffering from decreased or compromised blood flow to the brain. The apparatus includes a helmet configured to rest unsupported on the head of a mammal. The helmet includes outer and inner shells with at least one cavity intermediate the outer and inner shells for holding a coolant fluid within the at least one cavity, and a coolant source in communication with the helmet, the coolant source instantaneously providing a coolant fluid chilled to a temperature sufficient to slow the metabolism of the brain. When the coolant source is activated, the helmet becomes instantly chilled rapidly cooling the brain to a temperature sufficient to slow the metabolism of the brain a sufficient amount so that the mammal remains neurologically intact while efforts are made to restore regular blood flow to the brain of the mammal.

Abstract: A portable apparatus and corresponding method is provided for treating or preventing at least one of brain, brain-stem and associated nervous tissue injuries in a mammal suffering from decreased blood flow to the brain. The apparatus includes a flexible enveloping member for enveloping a head, neck and upper back of a mammal. The enveloping member includes outer and inner shells with at least one cavity intermediate the outer and inner shells for holding a coolant fluid within the at least one cavity. A coolant source is provided in communication with the enveloping member.

Abstract: This invention discloses a device and a method for resuscitating the brain as result of ischemic and anoxic injuries whereby the patient survives neurologically intact. The device includes a head enveloping helmet and neck supporting back plate with interconnected hollow cavities to allow chilled fluid from an activated coolant source to pass therethrough and subsequently chill the brain and upper spinal column. Once chilled, the brain's metabolism is slowed whereby resuscitation efforts can continue while neurologic damage is minimized. The method includes placing and adjusting the helmet on the patient's head, placing the back plate under the patient's neck and into abutment with the helmet, connecting the helmet to the coolant source and activating the coolant source.

Abstract: The invention discloses a method for treating brain and associated nervous tissue injury. The invention also discloses a method for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. Also disclosed is a method for organ preservation which employs body cavity perfusion. The methods include the introduction of temperature-controlled solutions to slow the metabolism of the brain, associated nervous tissue or organ(s) to inhibit degeneration thereof. A device which performs these methods is also disclosed. The device includes a fluid reservoir, an oxygen source, a heat exchanger and removable catheter lines.

Abstract: The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents.

Abstract: The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents.

Abstract: The invention discloses a method for providing circulation, usually when it has substantially decreased or ceased, such as during cardiac arrest. The method includes the steps of intubating the airway of a patient, to provide access to the lungs. The air and other material in the lungs is then evacuated. A liquid breathing solution is then infused into the lungs, expanding the lungs such that the lungs compress the heart and great vessels, to generate cardiac outflow and ultimately circulation. A device that performs this method is also disclosed.

Abstract: The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents.

Abstract: The invention discloses a method for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. The method includes the steps of catheterizing the vessels or tissues around the organ sought to be preserved, introducing a temperature controlled solution to cool the organ to inhibit degenerative metabolism, oxygenating the organ and inhibiting free radicle damage. The temperature controlled organ preservation solution includes perfluorocarbons, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.

Abstract: This invention discloses a device and a method for resuscitating the brain as result of ischemic and anoxic injuries whereby the patient survives neurologically intact. The device includes a head enveloping helmet and neck supporting back plate with interconnected hollow cavities to allow chilled fluid from an activated coolant source to pass therethrough and subsequently chill the brain and upper spinal column. Once chilled, the brain's metabolism is slowed whereby resuscitation efforts can continue while neurologic damage is minimized. The method includes placing and adjusting the helmet on the patient's head, placing the back plate under the patient's neck and into abutment with the helmet, connecting the helmet to the coolant source and activating the coolant source.

Abstract: An apparatus, for resuscitating the brain as a result of ischemic and anoxic injury where the patient survives neurologically intact, includes an oxygen source, a fluid reservoir, a heat exchanger, a pump, and removable catheter lines. The fluid solution may be delivered into the patient's circulatory system and ultimately to the brain by pumping, sufficient pressure from the oxygen source, or by a combination of pumping and oxygen pressure. Embodiments employing preoxygenated solution are also disclosed.

Abstract: This invention discloses a method for resuscitating the brain as a result of ischemic and anoxic injuries whereby the patient survives neurologically intact. The method includes the steps of catheterizing the patient's circulatory system and introducing a temperature controlled solution to cool the brain to a coma and a state of hypothermic shock, further driving the brain into a submetabolic coma, oxygenating the brain and inhibiting free radical damage, and continuing additional efforts at life support. The temperature controlled brain resuscitation solution includes barbituates, perfluorocarbons, antioxidants, brain and neurologic tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.

Abstract: The invention discloses a method for providing circulation, usually when it has substantially decreased or ceased, such as during cardiac arrest. The method includes the steps of intubating the airway of a patient, to provide access to the lungs. The air and other material in the lungs is then evacuated. A liquid breathing solution is then infused into the lungs, expanding the lungs such that the lungs compress the heart and great vessels, to generate cardiac outflow and ultimately circulation. A device that performs this method is also disclosed.