Abstract: A system includes a setting tool, which includes a housing, a piston, and an inner mandrel, and a settable device. The housing includes a first section configured as a setting sleeve, an intermediate section, and a second section. The piston includes an interior power charge chamber and a piston housing including at least one passage in fluid communication with the power charge chamber that interfaces with a top face of the intermediate section of the housing. The piston is mounted within a second bore of the second section via an anti-present mechanism. The inner mandrel is received in the second bore within a bottom recess of the piston housing and extends longitudinally through bores of the intermediate and first sections. At least a portion of the system is adjustable to eliminate a gap between the setting sleeve and a top of the settable device mounted on the inner mandrel.

Abstract: A technique facilitates multiple actuations of a toe valve system positioned along a tubing string. According to an embodiment, the toe valve system comprises a piston sleeve slidably disposed in an outer housing which has at least one port therethrough. The toe valve system also may comprise a shifting sleeve shiftable between positions with respect to the at least one port. The piston sleeve may initially be held in a position closing off the at least one port to prevent flow between the interior and exterior of the tubing string. The piston sleeve is held in this closed position via a liquid trapped in a piston chamber which is located between the piston sleeve and the outer housing. The liquid, e.g. oil, is retained in the piston chamber by a release member, e.g. a rupture disc, until sufficient pressure is applied within the toe valve system and against the piston sleeve so as to actuate the release member and to thus allow outflow of liquid from the piston chamber.

Abstract: A ski boot for anchoring to a ski via a ski binding system includes a rigid foot enclosure including a bottom wall having a first mating surface. The ski boot also includes a sole block configured to selectively couple to the rigid foot enclosure. The sole block includes a second mating surface configured to mate with the first mating surface, the second mating surface defining a mating surface plane. The sole block also includes a traction surface configured to engage a ground surface, the traction surface defining a traction surface plane. The sole block is configured to support an insert fitting, the insert fitting defining at least one of a) a pair of opposed sockets or b) a pair of arcuate cut-away portions. A non-zero cant angle is defined between the mating surface plane and the traction surface plane.

Abstract: A system includes a setting tool, which includes a housing, a piston, and an inner mandrel, and a settable device. The housing includes a first section configured as a setting sleeve, an intermediate section, and a second section. The piston includes an interior power charge chamber and a piston housing including at least one passage in fluid communication with the power charge chamber that interfaces with a top face of the intermediate section of the housing. The piston is mounted within a second bore of the second section via an anti-present mechanism. The inner mandrel is received in the second bore within a bottom recess of the piston housing and extends longitudinally through bores of the intermediate and first sections. At least a portion of the system is adjustable to eliminate a gap between the setting sleeve and a top of the settable device mounted on the inner mandrel.

Abstract: A technique facilitates collecting data, related to a fracturing, run-in-hole, or pull-out-of hole operation. A frac plug is provided with electronics for obtaining the desired information related to the operation. For example, the frac plug may be constructed with electronic sensors, a digital storage device, and a power supply or other power related equipment. Depending on the application, the frac plug may be a composite frac plug, degradable frac plug, dummy frac plug, or other suitable frac plug. Retrieval of the information obtained may be done via coupling with an associated device, e.g. inductive or physical coupling, by utilizing a broadcast transmitter/receiver, by physical retrieval of the storage device, or by physical retrieval of the dummy frac plug.

Abstract: A technique facilitates deployment and operation of actuatable plugs, e.g. frac plugs or bridge plugs. According to one embodiment, the plug comprises a flexible element slidably mounted on a portion of a cone, e.g. an upper cone. The upper cone comprises a tapered surface which works in cooperation with upper slips movably secured to the upper cone. The bridge plug also comprises a lower cone which comprises a lower tapered surface which works in cooperation with lower slips movably secured to the lower cone. Depending on the application, the plug may be constructed with each of these features combined into an overall assembly or with a portion of these features to facilitate plug operation in a specific environment and operation.

Abstract: A technique facilitates deployment and operation of actuatable plugs, e.g. frac plugs or bridge plugs. According to one embodiment, the plug comprises a flexible element slidably mounted on a portion of a cone, e.g. an upper cone. The upper cone comprises a tapered surface which works in cooperation with upper slips movably secured to the upper cone. The bridge plug also comprises a lower cone which comprises a lower tapered surface which works in cooperation with lower slips movably secured to the lower cone. Depending on the application, the plug may be constructed with each of these features combined into an overall assembly or with a portion of these features to facilitate plug operation in a specific environment and operation.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: Provided are compositions and methods for modulating cardiac cell hypertrophy and hyperplasia using inhibitors of c-Kit activity.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: An embodiment of the present invention includes a range generator to simplify equivalence checking. A range generator is constructed. The range generator is represented by a characteristic function of a range of a cut function for a cut circuit in an implementation circuit and a reference circuit. The range generator is simpler than the cut circuit. Equivalence of the implementation circuit and the reference circuit is checked using the range generator.

Abstract: An embodiment of the present invention includes a range generator to simplify equivalence checking. A range generator is constructed. The range generator is represented by a characteristic function of a range of a cut function for a cut circuit in an implementation circuit and a reference circuit. The range generator is simpler than the cut circuit. Equivalence of the implementation circuit and the reference circuit is checked using the range generator.

Abstract: A method of brewing a malt beverage having a low alcohol content is disclosed. A malt and cereal infusion having an extract content below about 14% is prepared, and boiled to obtain a wort. A predetermined quantity of hops are then added to said wort, which is then aerated. The wort is pitched with a yeast slurry to provide a cell count of about 80 to about 180 million yeast cells per ml and fermented at a temperature of about 3° C. to about 10° C. for 1 to 40 hours. The yeast is then removed from the fermented wort, and the resulting brew is filtered, and electrolyzed with a copper electrode to remove H2S. The alcohol concentration of the brew is then adjusted with carbonated water to a preselected level, and then the resultant brew is aged for at least 24 hours.

Abstract: The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

Abstract: A bell and plain end pipe joint are provided wherein the plain end has a raised portion on its outside diameter. A series of locking segments fit into a circumferential groove in the bell of one pipe and engage both the raised portion on the plain pipe and a portion of the bell. Upon an increase in fluid pressure in the pipes, the pipes tend to separate axially and the locking segments also contact and bear against a different portion of the bell. The joint provides a novel means of distributing the axial thrust tending to separate the pipe being joined.

Abstract: A device for holding nested bell and plain end push on joint pipes in a fixed position utilizing a novel frame work of simple members fastened firmly together. The inner pipe may be held concentrically or eccentrically with respect to the outer pipe.Padding may be added to protect inside coatings, and safety strapping offers added security that allows an abrasion resistant sheet to be held in place until disassembly occurs.

Abstract: A coupling for joining the plain ends of pipe; specifically, plain ended, cast iron soil pipe or plastic drain, waste and vent piping. The coupling is particularly adapted to ease of construction and yet furnishes the ability to join and seal pipe and fittings of a given nominal diameter over the full range of their tolerances with excellent rigidity.