Patents by Inventor Robert M. Grotzfeld

Robert M. Grotzfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE
    Publication number: 20170348320
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 7, 2017
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE
    Publication number: 20150126505
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE
    Publication number: 20140243525
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Application
    Filed: September 20, 2013
    Publication date: August 28, 2014
    Applicant: AMBIT BIOSCIENCES CORPORATION
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • Imidazolothiazole compounds for the treatment of disease
    Patent number: 8557810
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: October 15, 2013
    Assignee: Ambit Biosciences Corporation
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE
    Publication number: 20120129850
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Application
    Filed: January 24, 2012
    Publication date: May 24, 2012
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • Method of using imidazolothiazole compounds for the treatment of disease
    Patent number: 8129374
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: March 6, 2012
    Assignee: Ambit Bioscience Corporation
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • METHOD OF USING IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE
    Publication number: 20100298313
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Application
    Filed: August 4, 2010
    Publication date: November 25, 2010
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • Imidazolothiazole compounds for the treatment of disease
    Patent number: 7820657
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 26, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • Substituted 3-carboxamido isoxazoles as kinase modulators
    Patent number: 7767670
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: August 3, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Shamal A. Mehta, Robert M. Grotzfeld, Zdravko V. Milanov, Andiliy G. Lai, Hitesh K. Patel, David J. Lockhart
  • UREA DERIVATIVES AS ABL MODULATORS
    Publication number: 20100173917
    Abstract: The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: February 26, 2010
    Publication date: July 8, 2010
    Inventors: Robert M. Grotzfeld, Hitesh K. Patel, Shamal A. Mehta, Zdravkö V. Milanov, Andiliy G. Lai
  • Isoxazolyl urea derivatives as kinase modulators
    Patent number: 7750160
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: July 6, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Zdravko V. Milanov, Hitesh K. Patel, Robert M. Grotzfeld, Shamal A. Mehta, Andiliy G. Lai, David J. Lockhart
  • CONJUGATED SMALL MOLECULES
    Publication number: 20100048890
    Abstract: Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.
    Type: Application
    Filed: June 30, 2009
    Publication date: February 25, 2010
    Inventors: Robert M. Grotzfeld, Zdravko V. Milanov, Hitesh K. Patel, Andiliy G. Lai, Shamal A. Mehta, David J. Lockhart
  • Heterocyclic compounds and uses thereof
    Publication number: 20040248957
    Abstract: The invention provides compounds having the imidazole, oxazole, or thiazole skeleton and uses thereof. The compounds described herein bind to phosphodiesterase 6D. The compounds disclosed herein can be used to modulate the activity of phosphodiesterase 6. The invention provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects. Kits comprising the compounds of the invention are also provided.
    Type: Application
    Filed: May 17, 2004
    Publication date: December 9, 2004
    Applicant: Ambit Biosciences Corporation
    Inventors: David J. Lockhart, Hitesh K. Patel, Shamal Anil Mehta, Zdravko V. Milanov, Robert M. Grotzfeld, Andiliy G. Lai
  • Heterocyclic compounds and uses thereof
    Publication number: 20040242673
    Abstract: The invention provides compounds having the thiophene or furan skeleton and uses thereof. The invention provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects. Kits comprising the compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.
    Type: Application
    Filed: May 17, 2004
    Publication date: December 2, 2004
    Applicant: Ambit Biosciences Corporation
    Inventors: David J. Lockhart, Hitesh K. Patel, Shamal Anil Mehta, Zdravko V. Milanov, Robert M. Grotzfeld, Andiliy G. Lai