Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Systems and methods for Channel State Information (CSI) feedback on small control channels are provided. In some embodiments, a method of operation of a second node connected to a first node in a wireless communication network includes reporting CSI feedback to the first node on a physical channel. In some embodiments, this is accomplished by identifying a subset of codebook entries from an advanced CSI codebook of coefficients; selecting a codebook entry from the subset of codebook entries; and reporting an index of the selected codebook entry from the subset of codebook entries. This may allow robust feedback and allow variably sized cophasing and beam index indicators to be carried on the channel. Also, this may allow periodic feedback of advanced CSI on existing Physical Uplink Control Channel (PUCCH) Format 2.

Abstract: Embodiments provide methods of collecting stem cells. The methods can comprise connecting the proximal opening of the in-line cage device to a second device for liberating cells from a tissue in a fluid; connecting the distal opening of the in-line cage device to a suction or aspiration apparatus; and collecting stem cells on the graft or suture material. The graft can be e.g., demineralized bone matrix (DBM), bone, soft tissue, cartilage, tendon, ligament, muscle, adipose tissue, fascia, a suture, or an artificial scaffold. The second device for liberating cells can be an arthroscopic shaver, an arthroscopic bone cutter, an arthroscopic burr, or an arthroscopic drill. The method can further comprise connecting a filter device to the in-line cage device to remove tissue fragments from the fluid.

Abstract: A heat and moisture exchanger device comprising a housing containing a microcurrent-generating filter capable of generating a low level microcurrent. A microcurrent-generating filter can reduce the number of living or active microbes.

Abstract: The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

Abstract: The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

Abstract: Systems and methods for Channel State Information (CSI) feedback on small control channels are provided. In some embodiments, a method of operation of a second node connected to a first node in a wireless communication network includes reporting CSI feedback to the first node on a physical channel. In some embodiments, this is accomplished by identifying a subset of codebook entries from an advanced CSI codebook of coefficients; selecting a codebook entry from the subset of codebook entries; and reporting an index of the selected codebook entry from the subset of codebook entries. This may allow robust feedback and allow variably sized cophasing and beam index indicators to be carried on the channel. Also, this may allow periodic feedback of advanced CSI on existing Physical Uplink Control Channel (PUCCH) Format 2.

Abstract: Systems and methods for enabling precoding diversity in the time domain are provided. In some embodiments, a User Equipment (UE) includes circuitry including a processing module and a memory module configured to receive an indication that a physical channel is repeated over a set of subframes and receive an indication that the UE can assume that a first subset of the repetitions of the physical channel and a reference signal will use a first precoder. In this way, in some embodiments, the UE can coherently combine the repetitions, including the reference signals used by the physical channel. The ability to coherently combine repetitions of the physical channel may improve both the estimates of the physical channel as well as channel estimates derived from the repeated reference signals.

Abstract: Systems and methods for providing Channel State Information (CSI) feedback in a cellular communications network are disclosed. In some embodiments, a base station of a cellular communications network disables inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device and receives one or more CSI reports from the wireless device that are generated by the wireless device with inter-subframe channel interpolation of C SI-RS estimates across subframes disabled in response to the base station disabling inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device. In this manner, CSI feedback is improved particularly in embodiments in which the base station transmits a beamformed CSI-RS resource(s) and reuses the same CSI-RS resource(s) for different beams over time.

Abstract: Systems and methods for providing Channel State Information (CSI) feedback in a cellular communications network are disclosed. In some embodiments, a base station of a cellular communications network disables inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device and receives one or more CSI reports from the wireless device that are generated by the wireless device with inter-subframe channel interpolation of CSI-RS estimates across subframes disabled in response to the base station disabling inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device. In this manner, CSI feedback is improved particularly in embodiments in which the base station transmits a beamformed CSI-RS resource(s) and reuses the same CSI-RS resource(s) for different beams over time.

Abstract: A needle assembly according to an exemplary aspect of the present disclosure includes, among other things, a cannula, a trocar insertable through the cannula, the trocar including a shaft extending longitudinally between a proximal portion and a tip portion and a groove formed in the shaft and extending from near the tip portion at least partially toward the proximal portion.

Abstract: Systems and methods for providing Channel State Information (CSI) feedback in a cellular communications network are disclosed. In some embodiments, a base station of a cellular communications network disables inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device and receives one or more CSI reports from the wireless device that are generated by the wireless device with inter-subframe channel interpolation of CSI-RS estimates across subframes disabled in response to the base station disabling inter-subframe channel interpolation of CSI-RS estimates across subframes at the wireless device. In this manner, CSI feedback is improved particularly in embodiments in which the base station transmits a beamformed CSI-RS resource(s) and reuses the same CSI-RS resource(s) for different beams over time.

Abstract: A binding syringe and methods of use are disclosed. The binding syringe includes an outer body, a middle chamber, an inner body, and a plunger. The middle chamber has an outer surface including a plurality of pores, which are configured to retain certain components from biological fluid extracted by the outer body. A method of use includes placing a binding syringe into a patient or container, actuating the binding syringe to extract biological fluid, fluid flowing through a flowpath, and binding components of the biological fluid to be removed to the binding syringe.

Abstract: A binding syringe and methods of use are disclosed. The binding syringe includes an outer body, a middle chamber, an inner body, and a plunger. The middle chamber has an outer surface including a plurality of pores, which are configured to retain certain components from biological fluid extracted by the outer body. A method of use includes placing a binding syringe into a patient or container, actuating the binding syringe to extract biological fluid, fluid flowing through a flowpath, and binding components of the biological fluid to be removed to the binding syringe.

Abstract: The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

Abstract: A needle assembly according to an exemplary aspect of the present disclosure includes, among other things, a cannula, a trocar insertable through the cannula, the trocar including a shaft extending longitudinally between a proximal portion and a tip portion and a groove formed in the shaft and extending from near the tip portion at least partially toward the proximal portion.

Abstract: A communication system provides, via a single, serving Node B, scheduling information required by a user equipment (UE) to determine a start time for each Node B of multiple Node Bs with respect to a multicast, by each Node B of the multiple Node Bs, of soft combinable MBMS data. The UE may then use the scheduling information to synchronize a soft combining of the MBMS data received by the UE via each of the multiple Node Bs, even when the multicasts via the multiple Node Bs are not synchronized. However, while the multicasts of frames of data associated with an MBMS service by different Node Bs need not be synchronized, synchronized multicasts are preferable for soft combining. Therefore, the communication system further provides for a synchronization by a network controller of the multicasts of the soft combinable MBMS data by the multiple Node Bs.

Abstract: A method and apparatus for providing adaptive bearer configuration for MBMS delivery is disclosed. A first aspect of the present disclosure is a method of operating a wireless infrastructure entity (103) wherein a common radio resource (303) is allocated for receiving a response from at least one mobile station (109). A request message, similar to a request for counting, is broadcast to all mobile stations (109) within a coverage area (105). If at least one mobile station (109) responds to the request, PTM transmission mode will be used for MBMS delivery within the given coverage area (105). If more than one mobile station (109) within the coverage area (105) responds to the request, then all the responses will be over the common radio resource (303). The total number of responses to the request message may be limited by providing a probability factor within the request message.

Abstract: A communication device and method for controlling reverse link transmissions. The device receives a broadcast transmission signal and determines a quality level of the broadcast transmission signal. It then communicates with the base station to establish how frequently reverse link transmissions will occur depending on the determined quality level. Alternatively, a network element can determining when a parameter crosses a threshold and transmit a message to select wireless communication devices to start gating on a reverse link when the parameter crosses the threshold.

Abstract: A method an apparatus is described for providing feedback for closed-loop transmitting with multiple transmit and receive antennas. The method includes a first step 900 of providing a codebook containing sets of weightings for each data stream of the multiple transmit antennas with each set identified by an index known to a transmitter and a receiver. The same codebook is utilized for any number of data streams up to the number of transmit antennas. A next step 902 includes measuring a composite channel between the transmitter and receiver. A next step 904 includes determining at least one performance metric for each set of weightings in the codebook. A next step 906 includes selecting preferred weightings for each data stream in response to the performance metrics. A next step 908 includes feeding back an index of the preferred weightings to the transmitter for use in subsequent transmissions.