Patents by Inventor Robert M. Ippolito

Robert M. Ippolito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Administration of valienamine-related disaccharide compounds in reducing inflammation in a sensitized mammal arising from exposure to an antigen
    Patent number: 5814616
    Abstract: The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: September 29, 1998
    Assignee: Alberta Research Council
    Inventors: Om P. Srivastava, Roman Szweda, Richard H. Smith, Robert M. Ippolito, Ulrike Spohr
  • Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
    Patent number: 5646123
    Abstract: Disclosed are methods for reducing the degree of antigen induced inflammation in a sensitized mammals. The disclosed methods employ oligosaccharide glycosides related to blood group determinants having a type I or type II core structure wherein the administration of such oligosaccharide glycosides is after initiation of the mammal's immune response but at or prior one-half the period of time required to effect maximal antigen-induced inflammation.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: July 8, 1997
    Assignee: Alberta Research Council
    Inventors: Robert M. Ippolito, Wasimul Haque, Cong Jiang, H. Rizk Hanna, Andre P. Venot, Pandurang V. Nikrad, Mohammed A. Kashem, Richard Smith, Om P. Srivastava
  • Immunosuppressive and tolerogenic modified Lewis.sup.x compounds
    Patent number: 5580858
    Abstract: Disclosed are novel Lewis.sup.x and Lewis.sup.a analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: December 3, 1996
    Assignee: Alberta Research Council
    Inventors: Robert M. Ippolito, Wasimul Haque, Cong Jiang, H. Rizk Hanna, Andre P. Venot, Pandurang V. Nikrad, Mohammed A. Kashem, Richard H. Smith
  • Administration of valienamine-related disaccharide compounds in reducing inflammation in a sensitized mammal arising from exposure to an antigen
    Patent number: 5571796
    Abstract: The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 5, 1996
    Assignee: Alberta Research Council
    Inventors: Om P. Srivastava, Roman Szweda, Richard H. Smith, Robert M. Ippolito, Ulrike Spohr
  • Process for preparing substituted phenol ethers via oxazolidine-structure intermediates
    Patent number: 4760182
    Abstract: Phenol ethers such as 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-prop anol, otherwise known as betaxolol, of formula: ##STR1## are prepared from p-hydroxyphenethyl alcohol by first reacting at the phenolic group, with epichlorohydrin followed by isopropylamine, to prepare the required secondary amine-hydroxy side chain. Protection of the alcoholic group is not required during these steps. Then the secondary amine-alcohol group is protected by reaction with a suitable aldehyde such as benzaldehyde to form an oxazolidine ring protectant while the alcohol chain is elaborated. The oxazolidine ring protectant is removed by simple acid hydrolysis.
    Type: Grant
    Filed: February 25, 1986
    Date of Patent: July 26, 1988
    Assignee: Torcan Chemical Ltd.
    Inventors: Robert M. Ippolito, Stephen Vigmond
  • Process for preparing certain 1-lower alkanoyl or benzoyl-4-(lower alkanoyl or benzoyl-methylidene)-1,4-dihydropyridines or acid addition salts thereof
    Patent number: 4681944
    Abstract: There is described a novel process for preparing 4-pyridinylmethyl ketones of formula (I) ##STR1## wherein R is alkyl, aryl or aralkyl. The process involves hydrolysis of a compound ##STR2## generated by reaction of an acylating agent with 4-methylpyridine. The acylating agent may be selected from compounds of formula R-CO-X and R-CO-O-CO-R where R is as defined above and X represents halogen. Compounds of formula I have utility in the preparation of a variety of products, including pharmaceutically active 1,2-dihydro-6-R-2-oxo-5 pyridinyl compounds.
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: July 21, 1987
    Inventors: Robert M. Ippolito, Stephen Vigmond