Patents by Inventor Robert M. Johnston
Robert M. Johnston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131037Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans streptococci, Enterococcus, or combinations thereof.Type: ApplicationFiled: August 27, 2023Publication date: April 25, 2024Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
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Publication number: 20240098493Abstract: Techniques for identifying a trusted SSID for a wireless network are disclosed. Prior to establishing a connection with a wireless network, a first network message is received from a first access point (AP) identifying a first service set identifier (SSID) associated with a first wireless network, a second network message is received from a second AP identifying a second SSID associated with a second wireless network, and a visual similarity is determined between a first visual representation of the first SSID and a second visual representation of the second SSID. The second SSID is designated as suspicious based on the determined visual similarity.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Inventors: Jay K. JOHNSTON, Jerome HENRY, David C. WHITE, JR., Magnus MORTENSEN, John M. SWARTZ, Robert E. BARTON
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Patent number: 8352493Abstract: Searchable directories of health events are described. In many embodiments, a health event directory platform is provided that enables health providers to upload events to database of health events. The health event directory platform captures data from the health provider in a structured way that facilitates the searching of the database of health events. In addition, the health event directory platform uses knowledge of previous searches to suggest additional information to associate with a health event in order to increase the likelihood that the health event will appear in the results of a relevant search query. Users can provide requests for information to the health event directory platform, which uses the request to query the health events database and retrieve information concerning relevant health events within a particular geographic area. In many embodiments, the user can register for an event and/or pay using the health event directory platform.Type: GrantFiled: June 4, 2009Date of Patent: January 8, 2013Assignee: HW LLCInventors: Robert M. Johnston, IV, Alan Lawrence McCann, Richard Anthony Porter, Michelle Denise Robson, Jay D. Geer
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Patent number: 7696328Abstract: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.Type: GrantFiled: April 28, 2008Date of Patent: April 13, 2010Assignee: Bristol-Myers Squibb CompanyInventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
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Publication number: 20100088336Abstract: Searchable directories of health events are described. In many embodiments, a health event directory platform is provided that enables health providers to upload events to database of health events. The health event directory platform captures data from the health provider in a structured way that facilitates the searching of the database of health events. In addition, the health event directory platform uses knowledge of previous searches to suggest additional information to associate with a health event in order to increase the likelihood that the health event will appear in the results of a relevant search query. Users can provide requests for information to the health event directory platform, which uses the request to query the health events database and retrieve information concerning relevant health events within a particular geographic area. In many embodiments, the user can register for an event and/or pay using the health event directory platform.Type: ApplicationFiled: June 4, 2009Publication date: April 8, 2010Inventors: Robert M. Johnston, IV, Alan Lawrence McCann, Richard Anthony Porter, Michelle Denise Robson, Jay D. Geer
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Publication number: 20090104670Abstract: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.Type: ApplicationFiled: April 28, 2008Publication date: April 23, 2009Inventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
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Patent number: 7416876Abstract: This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.Type: GrantFiled: August 10, 2006Date of Patent: August 26, 2008Assignee: Bristol-Meyers Squibb CompanyInventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
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Patent number: 7119188Abstract: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.Type: GrantFiled: June 3, 2003Date of Patent: October 10, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
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Patent number: 7087418Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.Type: GrantFiled: December 16, 2002Date of Patent: August 8, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Steven L. Goldberg, Paul M. Cino, Ramesh N. Patel, Venkata B. Nanduri, Robert M. Johnston
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Patent number: 6929935Abstract: This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.Type: GrantFiled: December 16, 2002Date of Patent: August 16, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Venkata B. Nanduri, Robert M. Johnston, Steven L. Goldberg, Paul M. Cino, Ramesh N. Patel
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Patent number: 6880297Abstract: A modular system for assembling a storage unit is provided which includes a plurality of panels and different connectors. The system allows for subdividing spaces which may feature walls, floors, ceilings, etc. at varying angles or in areas having irregular contours. Additionally, the connectors are simple recesses and protrusions which allow for easy assembly and disassembly of the storage unit.Type: GrantFiled: February 22, 2002Date of Patent: April 19, 2005Inventor: Robert M. Johnston
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Patent number: 6800477Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.Type: GrantFiled: March 6, 2002Date of Patent: October 5, 2004Assignee: Bristol-Myers Squibb Co.Inventors: Ramesh Patel, Animesh Goswami, Linda N. Chu, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Mary Jo Donovan, K. David Mirfakhrae
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Publication number: 20040038237Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.Type: ApplicationFiled: December 16, 2002Publication date: February 26, 2004Inventors: Steven L. Goldberg, Paul M. Cino, Ramesh N. Patel, Venkata B. Nanduri, Robert M. Johnston
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Publication number: 20040023250Abstract: This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.Type: ApplicationFiled: December 16, 2002Publication date: February 5, 2004Inventors: Venkata B. Nanduri, Robert M. Johnston, Steven L. Goldberg, Paul M. Cino, Ramesh N. Patel
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Patent number: 6649387Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.Type: GrantFiled: April 26, 2001Date of Patent: November 18, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston
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Publication number: 20030159378Abstract: A modular system for assembling a storage unit is provided which includes a plurality of panels and different connectors. The system allows for subdividing spaces which may feature walls, floors, ceilings, etc. at varying angles or in areas having irregular contours. Additionally, the connectors are simple recesses and protrusions which allow for easy assembly and disassembly of the storage unit.Type: ApplicationFiled: February 22, 2002Publication date: August 28, 2003Inventor: Robert M. Johnston
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Publication number: 20030129030Abstract: A lubricant sheet for use in drilling holes in a printed circuit board, comprised of a porous, fibrous, organic sheet impregnated with a water-soluble lubricant. The lubricant is comprised essentially of polyethylene glycol having a weight average molecular weight between 4,500 and 7,000, and a surfactant.Type: ApplicationFiled: January 4, 2002Publication date: July 10, 2003Applicant: JJA, Inc.Inventor: Robert M. Johnston
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Publication number: 20030068811Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.Type: ApplicationFiled: March 6, 2002Publication date: April 10, 2003Inventors: Ramesh Patel, Animesh Goswami, Linda N. Chu, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Mary Jo Donovan, K. David Mirfakhrae
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Patent number: 6515170Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.Type: GrantFiled: April 26, 2001Date of Patent: February 4, 2003Assignee: Bristol-Myers Squibb Co.Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Thomas P. Tully, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, William J. Winter, Neal G. Anderson, David A. Lust, Gerard Crispino, Sushil K. Srivastava
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Publication number: 20020025566Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.Type: ApplicationFiled: April 26, 2001Publication date: February 28, 2002Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston