Patents by Inventor Robert M. Knabb

Robert M. Knabb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroquinoline derivatives useful as serine protease inhibitors
    Patent number: 7709646
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4, R5, R13, R14, R15 and R16 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: May 4, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mimi L. Quan, Cailan Wang, Jinglan Zhou, Jon J. Hangeland, Dietmar A. Seiffert, Robert M. Knabb
  • Combination of a factor Xa inhibitor and clopidogrel
    Patent number: 7018990
    Abstract: The present application describes methods of using a combination of 1-(3?-aminobenzisoxazol-5?-yl)-3-trifluoromethyl-5-[[4-[(2?-dimethylaminomethyl)imidazol-1?-yl]-2-fluorophenyl]aminocarbonyl]pyrazole-hydrochloric acid salt, a factor Xa inhibitor, and Clopidogrel as anticoagulant agents for treatment of thromboembolic disorders and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: March 28, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pancras C. Wong, Robert M. Knabb
  • Tetrahydroquinoline derivatives useful as serine protease inhibitors
    Publication number: 20040235847
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: March 9, 2004
    Publication date: November 25, 2004
    Inventors: Mimi L. Quan, Cailan Wang, Jinglan Zhou, Jon J. Hangeland, Dietmar A. Seiffert, Robert M. Knabb
  • Novel combination of a factor Xa inhibitor and clopidogrel
    Publication number: 20040067995
    Abstract: The present application describes methods of using a combination of 1-(3′-aminobenzisoxazol-5′-yl)-3-trifluoromethyl-5-[[4-[(2′-dimethylaminomethyl)imidazol-1′-yl]-2-fluorophenyl]aminocarbonyl]pyrazole-hydrochloric acid salt, a factor Xa inhibitor, and Clopidogrel as anticoagulant agents for treatment of thromboembolic disorders and pharmaceutical compositions containing the same.
    Type: Application
    Filed: September 25, 2003
    Publication date: April 8, 2004
    Inventors: Pancras C. Wong, Robert M. Knabb
  • Monoclonal antibodies to tissue plasminogen activator (T-PA) which prolong its functional half-life
    Patent number: 5225540
    Abstract: High-affinity murine monoclonal antibodies to t-PA were prepared which prolong the in vivo functional half-life of t-PA without decreasing its plasminogen-activator activity.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: July 6, 1993
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Thomas M. Reilly, Andrew T. Chiu, Robert M. Knabb