Patents by Inventor Robert M. Kral, Jr.

Robert M. Kral, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insecticidal peptides from spider venom
    Patent number: 5688764
    Abstract: This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for three of these peptides have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: November 18, 1997
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Janice H. Johnson, Robert M. Kral, Jr., Karen Krapcho
  • Insecticidal peptides from Segestria sp. spider venom
    Patent number: 5674846
    Abstract: This invention relates to an insecticidally effective peptide isolated from the spider, Segestria sp., characterized by its paralytic effect on insect pests and low mammalian toxicity. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: October 7, 1997
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Janice H. Johnson, Robert M. Kral, Jr.
  • Insecticidally effective peptides
    Patent number: 5461032
    Abstract: The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: October 24, 1995
    Assignees: FMC Corporation, NPS Pharmaceuticals, Inc.
    Inventors: Karen J. Krapcho, J. R. Hunter Jackson, Bradford C. VanWagenen, Robert M. Kral, Jr.
  • Insecticidally effective spider toxin
    Patent number: 5457178
    Abstract: This invention provides a family of insecticidally effective proteins and particular members of that family which may be isolated from the venom of the spider Filistata hibernalis, DNA encoding such proteins, insecticidal compositions of these proteins or the DNA encoding them, and methods for controlling invertebrate pests. Recombinant expression vectors and host cells and methods for producing insecticidally effective peptides are also provided.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: October 10, 1995
    Assignees: FMC Corporation, NPS Pharmaceuticals, Inc.
    Inventors: John R. H. Jackson, Karen J. Krapcho, Janice H. Johnson, Robert M. Kral, Jr.
  • Insecticidally effective peptides
    Patent number: 5441934
    Abstract: This invention provides a family of insecticidally effective peptides which may be isolated from Tegenaria spider venom, DNA encoding such insecticidally effective peptides and methods for controlling invertebrate pests.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: August 15, 1995
    Assignees: FMC Corporation, NPS Pharmaceuticals, Inc.
    Inventors: Karen J. Krapcho, John R. H. Jackson, Janice H. Johnson, Eric G. DelMar, Robert M. Kral, Jr.