Patents by Inventor Robert M. McKinnell

Robert M. McKinnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20240092758
    Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.
    Type: Application
    Filed: June 24, 2022
    Publication date: March 21, 2024
    Inventors: Robert Murray MCKINNELL, Tom M. LAM, Cameron SMITH, Philip GERKEN, Paul ALLEGRETTI, Gabrielle Elaine DOLGONOS, Christina OWENS
  • DUAL-ACTING ANTIHYPERTENSIVE AGENTS
    Publication number: 20120129900
    Abstract: The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 24, 2012
    Applicant: THERAVANCE, INC.
    Inventors: Seok-Ki CHOI, Paul R. FATHEREE, Sharath HEGDE, Ryan HUDSON, Keith JENDZA, Daniel MARQUESS, Robert M. MCKINNELL, Vivek SASIKUMAR
  • ARYL ANILINE DERIVATIVES AS BETA2 ADRENERGIC RECEPTOR AGONISTS
    Publication number: 20120071654
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 28, 2011
    Publication date: March 22, 2012
    Applicant: THERAVANCE, INC.
    Inventors: Robert M. McKinnell, John R. Jacobsen, Sean G. Trapp, Daisuke R. Saito
  • DUAL-ACTING ANTIHYPERTENSIVE AGENTS
    Publication number: 20100267788
    Abstract: The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicant: THERAVANCE, INC.
    Inventors: Seok-Ki CHOI, Paul R. FATHEREE, Sharath HEGDE, Ryan HUDSON, Keith JENDZA, Daniel MARQUESS, Robert M. McKINNELL, Vivek SASIKUMAR
  • Dual-acting antihypertensive agents
    Patent number: 7777077
    Abstract: The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: August 17, 2010
    Assignee: Theravance, Inc.
    Inventors: Seok-Ki Choi, Paul R. Fatheree, Ryan Hudson, Keith Jendza, Robert M. McKinnell, Vivek Sasikumar
  • ARYL ANILINE DERIVATIVES AS BETA2 ADRENERGIC RECEPTOR AGONISTS
    Publication number: 20100087410
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: October 6, 2009
    Publication date: April 8, 2010
    Applicant: Theravance, Inc.
    Inventors: Robert M. McKinnell, John R. Jacobsen, Sean G. Trapp, Daisuke R. Saito
  • Aryl aniline derivatives as ?adrenergic receptor agonists
    Patent number: 7622467
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: November 24, 2009
    Assignee: Theravance, Inc.
    Inventors: Robert M. McKinnell, John R. Jacobsen, Sean G. Trapp, Daisuke R. Saito
  • Oxamide IMPDH inhibitors
    Publication number: 20020052513
    Abstract: Disclosed are compounds of the general formula 1
    Type: Application
    Filed: February 8, 2001
    Publication date: May 2, 2002
    Inventors: Michael J. Broadhurst, Christopher H. Hill, David N. Hurst, Philip S. Jones, Paul B. Kay, Ian R. Kilford, Robert M. McKinnell