Abstract: A parallel high throughput method and kit for the discovery of small molecule interactors of target proteins, in particular, target proteins expressed from entire genomes or subsets thereof. The target module is prepared by binding selectively a target protein, modified to allow its detection, to a surrogate ligand that is linked to an individually detectable bead. Sets of target modules are mixed together in each chamber of a multi-chamber container. A test compound or collection of test compounds is added to each chamber, and the interaction of a compound with each target module is observed. A compound that is specific for a particular target protein will displace that protein from its target module. The identity of the target module so disrupted is determined by identifying the particular bead to which the displaced target protein was attached.

Abstract: Disclosed is a projectile that has high velocity at short range. The projectile has a body of material that is lighter, more lubricous and more deformable than a partial Jacket on the rearward portion of the projectile. The jacket defines an annular array of apertures on the outer diametrical surface of the jacket and the body has peripheral zones that extend into the apertures far enough to be flush with the outer diametrical surface. The peripheral zones not only provide a physical lock between the body and jacket but also lubricate the interface between the projectile and the gun barrel along which the projectile travels during firing of a gun. The apertures are configured to allow the body to erupt radially outward through the jacket's side wall and form a relatively wide, shallow dispersal pattern when the projectile impacts a target. An optional core within the plastic body enhances the body's radially outward dispersal upon the projectile's impact with a target.

Abstract: Disclosed is a projectile that has high velocity at short range. The projectile has a body of material that is lighter, more lubricous and more deformable than a partial jacket on the rearward portion of the projectile. The jacket defines an annular array of apertures on the outer diametrical surface of the jacket and the body has peripheral zones that extend into the apertures far enough to be flush with the outer diametrical surface. The peripheral zones not only provide a physical lock between the body and jacket but also lubricate the interface between the projectile and the gun barrel along which the projectile travels during firing of a gun. The apertures are configured to allow the body to erupt radially outward through the jacket's side wall and form a relatively wide, shallow dispersal pattern when the projectile impacts a target. An optional core within the plastic body enhances the body's radially outward dispersal upon the projectile's impact with a target.

Abstract: The invention is an improved partially jacketed projectile intended for small arms use. The projectile includes a central stem integral with a rear wall of the projectile, the rear wall in turn being integral with the partial jacket. A core surrounding the stem and encased by the jacket is softer than the material forming the stem, rear wall and jacket. The jacket retards core petalling during initial projectile impact whereas the rear wall configuration enhances petalling when the projectile achieves subsequent target penetration.

Abstract: Disclosed is a load platform translatable along rails mounted to the exterior of a vehicle, the platform being tiltably mounted upon an axle extending between the rails. Supported on the axle is a manually releasable locking mechanism in which the axle rotates, the locking mechanism acting to maintain the axle and platform in a given translational position along the rails.