Abstract: An integrated system for monitoring conditions of a patient and adjusting treatment for the patient based on comparisons of acquired data and historical data related to the patient includes a central processor, an oxygen concentrator, a level of consciousness monitor and a mobile device. The oxygen concentrator, the level of consciousness monitor and the mobile device are in communication with the central processor. The central processor includes a sleep database having baseline sleep information for a generic patient. The oxygen concentrator is configured to provide a flow of concentrated oxygen to the patient. The level of consciousness monitor is configured to collect data regarding the patient's state of wakefulness, awareness and alertness. The central processor collects data from the oxygen concentrator, the level of consciousness monitor and the mobile device and adjusts the oxygen concentrator based on comparisons of the baseline sleep information and the collected data.

Abstract: A portable oxygen delivery system including an oxygen concentrator having a housing, a compressor mounted inside the housing, a sieve module located within the housing and in fluid connection with the compressor, the sieve module containing a zeolite for removing Nitrogen from air through a pressure swing adsorption process for creating concentrated oxygen, a power source attached to the housing and an oxygen controller device for electronically controlling the pressure swing adsorption process. The portable oxygen delivery system also preferably includes a blowing apparatus fluidly connected to the oxygen concentrator having a blower housing, a blower motor mounted inside the blower housing, a blower fan connected to the blower motor, a second power source attached to the blower housing and a blower controller device for electronically controlling the blower.

Abstract: A device and a system that delivers continuous positive airway pressure in conjunction with oxygen delivery is disclosed. The system is portable so that patients may be mobile and conveniently travel. Several means are disclosed for integrating oxygen production into a positive airway pressure (PAP) device, including oxygen production machinery entirely integrated into the PAP housing, oxygen production machinery that mates with a PAP device but which may operate independently, and where portions of the oxygen production machinery are located in the PAP housing and other portions (for example, the compressor) are located in a separate module, such as, for example, an AC-to-DC power conversion module.

Abstract: A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

Abstract: A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

Abstract: An integrated system for monitoring conditions of a patient and adjusting treatment for the patient based on comparisons of acquired data and historical data related to the patient includes a central processor, an oxygen concentrator, a level of consciousness monitor and a mobile device. The oxygen concentrator, the level of consciousness monitor and the mobile device are in communication with the central processor. The central processor includes a sleep database having baseline sleep information for a generic patient. The oxygen concentrator is configured to provide a flow of concentrated oxygen to the patient. The level of consciousness monitor is configured to collect data regarding the patient's state of wakefulness, awareness and alertness. The central processor collects data from the oxygen concentrator, the level of consciousness monitor and the mobile device and adjusts the oxygen concentrator based on comparisons of the baseline sleep information and the collected data.

Abstract: A configurable oxygen concentrator for providing various flow rates and volumes of concentrated oxygen to a patient includes an electro-mechanical assembly having a housing with a first face, a second face and an outer surface. The oxygen concentrator also includes a first battery, a second battery, a first adsorbent container and a second adsorbent container. The first and second batteries are removably mountable to the first face and the first and second adsorbent containers are removably mountable to the second face to permit modification of the concentrated oxygen capacity and operating life of the concentrator as the patient progresses through different stages of a breathing disease. The first battery has a first battery capacity that is less than a second battery capacity of the second battery. The first adsorbent container has a first adsorbent capacity that is less than a second adsorbent capacity of the second adsorbent container.

Abstract: A configurable oxygen concentrator for providing various flow rates and volumes of concentrated oxygen to a patient includes an electro-mechanical assembly having a housing with a first face, a second face and an outer surface. The oxygen concentrator also includes a first battery, a second battery, a first adsorbent container and a second adsorbent container. The first and second batteries are removably mountable to the first face and the first and second adsorbent containers are removably mountable to the second face to permit modification of the concentrated oxygen capacity and operating life of the concentrator as the patient progresses through different stages of a breathing disease. The first battery has a first battery capacity that is less than a second battery capacity of the second battery. The first adsorbent container has a first adsorbent capacity that is less than a second adsorbent capacity of the second adsorbent container.

Abstract: A configurable oxygen concentrator for providing various flow rates and volumes of concentrated oxygen to a patient includes an electro-mechanical assembly having a housing with a first face, a second face and an outer surface. The oxygen concentrator also includes a first battery, a second battery, a first adsorbent container and a second adsorbent container. The first and second batteries are removably mountable to the first face and the first and second adsorbent containers are removably mountable to the second face to permit modification of the concentrated oxygen capacity and operating life of the concentrator as the patient progresses through different stages of a breathing disease. The first battery has a first battery capacity that is less than a second battery capacity of the second battery. The first adsorbent container has a first adsorbent capacity that is less than a second adsorbent capacity of the second adsorbent container.

Abstract: A device and a system that delivers continuous positive airway pressure in conjunction with oxygen delivery is disclosed. The system is portable so that patients may be mobile and conveniently travel. Several means are disclosed for integrating oxygen production into a positive airway pressure (PAP) device, including oxygen production machinery entirely integrated into the PAP housing, oxygen production machinery that mates with a PAP device but which may operate independently, and where portions of the oxygen production machinery are located in the PAP housing and other portions (for example, the compressor) are located in a separate module, such as, for example, an AC-to-DC power conversion module.

Abstract: Embolic protection aspirators and methods for extracting debris from the vasculature during interventional procedures are provided. One such system may include an aspirating filter delivery catheter having a filtration device, an operable end cap, and a plurality of aspiration ports. The delivery catheter may be fluidly coupled to a suction providing means for extracting debris while traversing a target site for distal delivery of the filtration device. Another such system may include an aspirating filter retrieval catheter having an aspiration lumen and a balloon. The aspiration lumen may be fluidly coupled to a suction providing means for extracting debris from the filtration device prior to and/or during retrieval of the filtration device. By inflating the balloon to partially or fully restrict blood flow, suction pressure proximal of the filtration device may be increased to enhance debris extraction.

Abstract: An apparatus includes a body configured to be at least partially inserted into a rectum of a patient. The body defines a first passageway and a second passageway between a proximal end portion and a distal end portion. The first passageway is configured to receive a medical tool and the second passageway is configured to communicate an insufflation medium. An insufflation port is coupled to the second passageway and is configured to communicate the insufflation medium to the second passageway. A retention portion is coupled to the body and is configured to have a dimension transverse to an axis defined by the body sufficient to retain at least a portion of the body in the rectum. The retention portion is configured to be located beyond an anus of the patient.

Abstract: An embodiment of the invention includes inserting into a gastrointestinal lumen, a catheter having a first balloon and a second balloon spaced from the first balloon. The first balloon and the second balloon are inflated to sealingly engage the lumen. A liquid is introduced into a volume bounded by the first balloon, the second balloon and the lumen so that the liquid contacts at least a portion of the lumen.

Abstract: An apparatus includes an elongate body configured to be at least partially inserted into a gastrointestinal lumen. The elongate body is configured to perform a medical procedure within the gastrointestinal lumen. A beacon element is coupled to the elongate body. The beacon element is configured to be identified within the gastrointestinal lumen using a sensing device. A method includes imaging a gastrointestinal lumen with an imaging device. An apparatus is inserted at least partially into a gastrointestinal lumen. The apparatus has an elongate portion, a tool portion and a beacon element. The location of the beacon element is identified within the gastrointestinal lumen using a sensing device. The tool portion is moved to an area of interest within the gastrointestinal lumen based on the location of the beacon element.

Abstract: An apparatus includes an elongate body having a plurality of discretely controllable portions. The plurality of discretely controllable portions are configured to be maneuvered within a body lumen along a predetermined path associated with an image of the body lumen. At least one portion from the plurality of discretely controllable portions may include a marker. A method includes inserting an elongate body at least partially into a body lumen. The elongate body has a plurality of discretely controllable portions. The elongate body is maneuvered within the body lumen along a predetermined path associated with an image of the body lumen. The maneuvering includes changing the relative orientation of the plurality of discretely controllable portions.

Abstract: An occlusion device for occluding a body conduit including an elongate tubular shaft having an inflatable balloon disposed near the elongate shaft distal end and a proximal seal having a sufficiently small profile to allow a second catheter to pass over the distal occlusion device while the inflatable balloon remains uninflated. One occlusion device includes an elongate fluid displacement rod within the occlusion device elongate shaft, providing both a fluid pressure source and a seal. The elongate rod can be rapidly advanced and retracted, providing rapid and controlled inflation and deflation of the distal balloon. Also provided are alignment devices for aligning inflation fluid sources with occlusion device tubular proximal ends which can inject fluid through the device into the distal balloon.

Abstract: An occlusion device for occluding a body conduit including an elongate tubular shaft having an inflatable balloon disposed near the elongate shaft distal end and a proximal seal having a sufficiently small profile to allow a second catheter to pass over the distal occlusion device while the inflatable balloon remains uninflated. One occlusion device includes an elongate fluid displacement rod within the occlusion device elongate shaft, providing both a fluid pressure source and a seal. The elongate rod can be rapidly advanced and retracted, providing rapid and controlled inflation and deflation of the distal balloon. Also provided are alignment devices for aligning inflation fluid sources with occlusion device tubular proximal ends which can inject fluid through the device into the distal balloon.

Abstract: An occlusion device for occluding a body conduit including an elongate tubular shaft having an inflatable balloon disposed near the elongate shaft distal end and a proximal seal having a sufficiently small profile to allow a second catheter to pass over the distal occlusion device while the inflatable balloon remains uninflated. One occlusion device includes an elongate fluid displacement rod within the occlusion device elongate shaft, providing both a fluid pressure source and a seal. The elongate rod can be rapidly advanced and retracted, providing rapid and controlled inflation and deflation of the distal balloon.

Abstract: A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant also includes a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.

Abstract: A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can also include a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.