Patents by Inventor Robert M. Strongin
Robert M. Strongin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230002803Abstract: Seminaphthofluorophore-selenium probes are disclosed. The probes include a seminaphthofluorophore scaffold substituted with at least one diselenide moiety having a formula —Y—C(Q)O—(CH2)m—Se—Se—(CH2)n—ORf, where Rf is hydrogen or C1-C3 alkyl, Q is O or S, Y is O or N(Rg) where Rg is H or alkyl, and m and n independently are integers. The probes may be used to detect presence of a thioredoxin reductase.Type: ApplicationFiled: September 24, 2020Publication date: January 5, 2023Applicant: Portland State UniversityInventors: Robert M. Strongin, Jorge O. Escobedo Cordova, Tendai Mafireyi
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Patent number: 11191850Abstract: Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.Type: GrantFiled: May 23, 2017Date of Patent: December 7, 2021Assignee: Portland State UniversityInventors: Robert M Strongin, Martha Sibrian-Vazquez, Lei Wang, Jorge O. Escobedo Cordova, Mark A. Lowry
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Publication number: 20200330612Abstract: Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.Type: ApplicationFiled: May 23, 2017Publication date: October 22, 2020Applicant: Portland State UniversityInventors: Robert M Strongin, Martha Sibrian-Vazquez, Lei Wang, Jorge O. Escobedo Cordova, Mark A. Lowry
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Patent number: 10773238Abstract: Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.Type: GrantFiled: February 23, 2016Date of Patent: September 15, 2020Assignee: Portland State UniversityInventors: Robert M. Strongin, Martha Sibrian-Vazquez, Jialu Wang, Jorge O. Escobedo-Cordova
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Publication number: 20180071716Abstract: Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.Type: ApplicationFiled: February 23, 2016Publication date: March 15, 2018Applicant: Portland State UniversityInventors: Robert M. Strongin, Martha Sibrian-Vazquez, Jialu Wang, Jorge O. Escobedo-Cordova
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Patent number: 9506929Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.Type: GrantFiled: February 22, 2013Date of Patent: November 29, 2016Assignee: Portland State UniversityInventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
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Publication number: 20160311760Abstract: Compounds and methods thereof for reducing cardiac arrhythmia are described. In particular, compounds generated by adding chemical groups that enhance the electron donor properties of RyR inhibitors may increase inhibitor potency and thus allow for new more potent anti-arrhythmic drugs. One advantage of the compounds and methods described is a potential for drugs with enhanced electron donor properties that may be used at lower concentrations and exhibit less non-specific effects.Type: ApplicationFiled: December 5, 2014Publication date: October 27, 2016Inventors: Robert M. Strongin, Jonathan J. Abramson, Martha Sibrian-Vazquez, Xander Wehrens
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Patent number: 9201075Abstract: Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and cysteine, and do not cross-react substantially with chemically-related species such as glutathione. The homocysteine-selective method does not have substantial cross-reactivity to the very closely related species cysteine. The cysteine-selective method does not have substantial cross-reactivity to the very closely related species homocysteine. The methods may be used, for example, in a direct assay of human blood plasma for homocysteine levels.Type: GrantFiled: April 27, 2005Date of Patent: December 1, 2015Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Robert M. Strongin, Weihua Wang, Oleksandr Rusin, Nadia N. St. Luce, Jorge O. Escobedo Cordova
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Publication number: 20150010938Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.Type: ApplicationFiled: February 22, 2013Publication date: January 8, 2015Applicant: Oregon State Board of Higher Education on Behalf of Portland State UniversityInventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
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Patent number: 8350064Abstract: Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.Type: GrantFiled: July 19, 2007Date of Patent: January 8, 2013Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Robert M. Strongin, Isiah M. Warner, Youjun Yang, Mark Lowry, Sayo O. Fakayode, Jorge O. Escobedo Cordova, Xiangyang Xu
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Publication number: 20100291689Abstract: A group of water-soluble salophene-lanthanide complexes and other salophene-metal complexes are useful for purposes including: (i) detecting neutral carbohydrates at physiologically-relevant pH, (ii) the selective detection of gangliosides, and (iii) the selective detection of lysophosphatidic acid (LPA) in the presence of phosphatidic acid. The selective detection of LPA is useful in diagnosing ovarian and other cancers.Type: ApplicationFiled: March 14, 2007Publication date: November 18, 2010Applicants: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY & AGRICULTURAL AND MECHANICAL COLLEGE, INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Robert M. Strongin, Onur Alptürk, Oleksandr Rusin, Sayo O. Fakayode, Jorge O. Escobedo Cordova, Weihua Wang, Isiah M. Warner, William E. Crowe, Vladimir Král
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Publication number: 20100051826Abstract: Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.Type: ApplicationFiled: July 19, 2007Publication date: March 4, 2010Inventors: Robert M. Strongin, Isiah M. Warner, Youjun Yang, Mark Lowry, Sayo O. Fakayode, Jorge O. Escobedo Cordova, Xiangyang Xu
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Publication number: 20080261315Abstract: Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and cysteine, and do not cross-react substantially with chemically-related species such as glutathione. The homocysteine-selective method does not have substantial cross-reactivity to the very closely related species cysteine. The cysteine-selective method does not have substantial cross-reactivity to the very closely related species homocysteine. The methods may be used, for example, in a direct assay of human blood plasma for homocysteine levels.Type: ApplicationFiled: April 27, 2005Publication date: October 23, 2008Inventors: Robert M. Strongin, Weihua Wang, Olesandr Rusin, Nadia N. St. Luce, Jorge O. Escobedo Cordova
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Patent number: 6555528Abstract: An efficient synthesis for the selective and efficient 1′-N derivatization of biotin is reported. The derivatized biotin acts as a stable analog of the carboxyphosphate intermediate in naturally-occurring biotin-mediated CO2 transfer. The synthesis may readily be scaled up to perform large-scale, selective acylations of biotin. The stable analog of the intermediate can inhibit the activity of the biotin carboxylase enzymes such as acetyl CoA carboxylase, and HIV protease. The functionalization at the 1′-N of biotin results in the attachment of an electrophilic “handle” amenable to reaction with a wide variety of nucleophiles to generate a new family of biotin analogs.Type: GrantFiled: April 6, 2001Date of Patent: April 29, 2003Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Robert M. Strongin, Marcelo C. Saraiva, Grover L. Waldrop, David R. Amspacher
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Patent number: 6534316Abstract: Methods are disclosed for the simple, rapid, and selective colorimetric detection of carbohydrates, including fructose, glucose, sialic acid, and oligosaccharides. There is no need for any prior hydrolysis or other chemical modification or of the analytes. Resorcinarenes, xanthene dyes, and related compounds, formally produced by the reaction of 2 equivalents of resorcinol and a suitable electrophilic condensation partner, are used as chromophores or fluorophores for the detection of sugars and other carbohydrates.Type: GrantFiled: February 5, 2001Date of Patent: March 18, 2003Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Robert M. Strongin, Larry Allen Cabell, Nadia St. Luce, Patrick T. Lewis, Ming He, Jorge O. Escobedo Cordova, Claude Joseph Davis
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Publication number: 20020142475Abstract: Methods are disclosed for the simple, rapid, and selective colorimetric detection of carbohydrates, including fructose, glucose, sialic acid, and oligosaccharides. There is no need for any prior hydrolysis or other chemical modification or of the analytes. Resorcinarenes, xanthene dyes, and related compounds, formally produced by the reaction of 2 equivalents of resorcinol and a suitable electrophilic condensation partner, are used as chromophores or fluorophores for the detection of sugars and other carbohydrates.Type: ApplicationFiled: February 5, 2001Publication date: October 3, 2002Inventors: Robert M. Strongin, Larry Allen Cabell, Nadia St. Luce, Patrick T. Lewis, Ming He, Jorge O. Escobedo Cordova, Claude Joseph Davis
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Publication number: 20010016343Abstract: An efficient synthesis for the selective and efficient 1′-N derivatization of biotin is reported. The derivatized biotin acts as a stable analog of the carboxyphosphate intermediate in naturally-occurring biotin-mediated CO2 transfer. The synthesis may readily be scaled up to perform large-scale, selective acylations of biotin. The stable analog of the intermediate can inhibit the activity of the biotin carboxylase enzymes such as acetyl CoA carboxylase, and HIV protease. The functionalization at the 1′-N of biotin results in the attachment of an electrophilic “handle” amenable to reaction with a wide variety of nucleophiles to generate a new family of biotin analogs.Type: ApplicationFiled: April 6, 2001Publication date: August 23, 2001Inventors: Robert M. Strongin, Marcelo C. Saraiva, Grover L. Waldrop, David R. Amspacher
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Patent number: 6242610Abstract: An efficient synthesis for the selective and efficient 1′-N derivatization of biotin is reported. The derivatized biotin acts as a stable analog of the carboxyphosphate intermediate in naturally-occurring biotin-mediated CO2 transfer. The synthesis may readily be scaled up to perform large-scale, selective acylations of biotin. The stable analog of the intermediate can inhibit the activity of the biotin carboxylase enzymes such as acetyl CoA carboxylase, and HIV protease. The functionalization at the 1′-N of biotin results in the attachment of an electrophilic “handle” amenable to reaction with a wide variety of nucleophiles to generate a new family of biotin analogs.Type: GrantFiled: May 27, 1999Date of Patent: June 5, 2001Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Robert M. Strongin, Marcelo C. Saraiva, Grover L. Waldrop, David R. Amspacher