Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: An automated beverage-making system includes one or more ingredient dispenser assemblies configured to store ingredients therein and disposed within a refrigerator/freezer system. Each of the ingredient dispenser assembles are in control communication with a communications hub and the communications hub is configured to receive instructions for actuating the one or more ingredient dispenser assemblies according to a recipe, wherein the ingredients are combined in a blender.

Abstract: A method and assembly are provided for securing a stent within a vessel of a subject. The method includes moving the stent to a position along the vessel and inflating a balloon positioned on a downstream side of the stent. The method further includes deploying the stent at the position and verifying that the deployed stent does not float from the position in a downstream direction relative to the inflated balloon. The method further includes deflating the balloon. The assembly includes the stent, a plurality of channels internal to the stent and a deployment mechanism configured to deploy the stent when the stent is positioned in the vessel of the subject. In another embodiment, a system is provided that includes the assembly, a guide wire, a balloon lumen, an inlet port to inject fluid into the balloon lumen and a handle operatively coupled to the deployment mechanism.

Abstract: The present invention provides a water lubricated line shaft bearing assembly, comprising an outer annular steel shell and an inner layer made of low friction material attached to the outer shell, the inner layer having a non-uniform thickness which is formed with wall portions of increased thickness defining a plurality of shaft engaging portions and with wall portions of reduced thickness defining a plurality of lubricant passages. The shaft engaging portions are capable of being journalled on a line shaft adapted to drive a downhole geothermal production pump and the steel shell is engageable with an inner wall of a lubrication tube vertically extending through a water column through which pumped geothermal fluid is delivered, lubrication water bled from the pumped geothermal fluid being used to supply lubrication water through the lubricant passages.

Abstract: The present invention provides a water lubricated line shaft bearing assembly, comprising an outer annular steel shell and an inner layer made of low friction material attached to the outer shell, the inner layer having a non-uniform thickness which is formed with wall portions of increased thickness defining a plurality of shaft engaging portions and with wall portions of reduced thickness defining a plurality of lubricant passages. The shaft engaging portions are capable of being journalled on a line shaft adapted to drive a downhole geothermal production pump and the steel shell is engageable with an inner wall of a lubrication tube vertically extending through a water column through which pumped geothermal fluid is delivered, lubrication water bled from the pumped geothermal fluid being used to supply lubrication water through the lubricant passages.

Abstract: Bismuth vanadate (BiVO.sub.4) is prepared by reaction in nitric acid suspension of a solid bismuth-containing compound and a solid vanadium-containing compound while being subjected to milling at a temperature from 20.degree.-100.degree. C. The bismuth vanadate prepared by this process is a bright, high tinting yellow pigment particularly useful in pigmenting polymers and paints.

Abstract: An improved solid state process for the preparation of compounds based on bismuth vanadate wherein the improvement comprises subjecting the reaction product to wet grinding in alkaline solution or to sequential wet grinding and alkaline treatment, said process modification resulting in the preparation of bright, high tinting yellow pigments.

Abstract: In glass enamel coating compositions containing a glass frit system and a vehicle therefor, the improvement comprising the presence therein of iron, aluminum, zinc and tin sulfides or sulfates as an anti-stick agent; the resulting coatings being effective for application to glass sheets which are subsequently subjected to high temperature forming procedures.