Patents by Inventor Robert M. Sutherland

Robert M. Sutherland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170035938
    Abstract: Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.
    Type: Application
    Filed: March 7, 2016
    Publication date: February 9, 2017
    Inventors: Chandan Guha, Robert M. Sutherland, Alan Alfieri, Jayanta Roy-Chowdury
  • Patent number: 9314486
    Abstract: Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: April 19, 2016
    Assignees: Varian Medical Systems, Inc., Montefiore Medical Center
    Inventors: Chandan Guha, Robert M. Sutherland, Alan Alfieri, Jayanta Roy-Chowdury
  • Patent number: 7700923
    Abstract: An image acquisition device having a photoconductor, a substrate including a detector array and an interlayer between the photoconductor and the substrate is disclosed. The interlayer is formed of molecules having a first ligand selectively binding the substrate and a second ligand selectively binding the photoconductor.
    Type: Grant
    Filed: September 20, 2008
    Date of Patent: April 20, 2010
    Assignee: Varian Medical Systems, Inc.
    Inventors: Michael C. Green, Robert M. Sutherland
  • Publication number: 20100072382
    Abstract: An image acquisition device comprises a photoconductor, a substrate including a detector array, and an interlayer between the photoconductor and the substrate, wherein the interlayer is formed of molecules having a first ligand and a second ligand.
    Type: Application
    Filed: September 20, 2008
    Publication date: March 25, 2010
    Applicant: Varian Medical Systems, Inc.
    Inventors: Michael C. Green, Robert M. Sutherland
  • Publication number: 20090304589
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposome composition comprising a stable liposome-forming lipid and a polymerizable colipid, and a chain transfer agent. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: September 26, 2008
    Publication date: December 10, 2009
    Applicant: Varian Medical Systems,Inc.
    Inventors: Bruce Bondurant, Kathy A. McGovern, Robert M. Sutherland
  • Publication number: 20080233088
    Abstract: The invention relates to methods of obtaining an expanded population of mammalian ex vivo cells and/or for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested for further use or be left at the engraftment site of a subject to be treated. The invention also provides methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury.
    Type: Application
    Filed: February 15, 2008
    Publication date: September 25, 2008
    Applicants: Varian Medical Systems Technologies, Inc., Montefiore Medical Center
    Inventors: Chandan Guha, Robert M. Sutherland, Alan Alfieri, Jayanta Roy-Chowdury
  • Patent number: 7403638
    Abstract: A method and system for monitoring breathing movement of a subject is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.
    Type: Grant
    Filed: October 14, 2006
    Date of Patent: July 22, 2008
    Assignee: Varian Medical Systems Technologies, Inc.
    Inventors: Andrew Jeung, Hassan Mostafavi, Majid L. Riaziat, Robert M. Sutherland, George Zdasiuk
  • Patent number: 7123758
    Abstract: A method and system for monitoring breathing movement of a subject is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: October 17, 2006
    Assignee: Varian Medical Systems Technologies, Inc.
    Inventors: Andrew Jeung, Hassan Mostafavi, Majid L. Riaziat, Robert M. Sutherland, George Zdasiuk
  • Patent number: 6980679
    Abstract: A method and system for monitoring breathing movement of an infant is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: December 27, 2005
    Assignee: Varian Medical System Technologies, Inc.
    Inventors: Andrew Jeung, Hassan Mostafavi, Majid L. Riaziat, Robert M. Sutherland, George Zdasiuk
  • Publication number: 20040071337
    Abstract: A method and system for monitoring breathing movement of a subject is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.
    Type: Application
    Filed: December 20, 2002
    Publication date: April 15, 2004
    Inventors: Andrew Jeung, Hassan Mostafavi, Majid L. Riaziat, Robert M. Sutherland, George Zdasiuk
  • Publication number: 20040005088
    Abstract: A method and system for monitoring breathing movement of an infant is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.
    Type: Application
    Filed: November 25, 2002
    Publication date: January 8, 2004
    Inventors: Andrew Jeung, Hassan Mostafavi, Majid L. Riaziat, Robert M. Sutherland, George Zdasiuk
  • Patent number: 6428504
    Abstract: An apparatus and method to implement and control a plurality of minimally invasive therapies in the treatment of a medical condition of a patient based on a treatment plan. The apparatus includes a template which has a plurality of electrically conductive apertures, a plurality of needles which have a plurality of sensors and a processor. At least one of the needles is inserted through and in electrical contact with one of the conductive apertures. The processor is electrically coupled to the template and is configured to send signals to and receive signals from at least one of the sensors of at least one of the needles inserted through one of the conductive apertures. The processor is further configured to process the signals received from the sensor in relation to the treatment plan and to adjust the signals sent to the sensor to control the treatment.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: August 6, 2002
    Assignee: Varian Medical Systems, Inc.
    Inventors: Majid L. Riaziat, George A. Zdasiuk, Robert M. Sutherland, Andrew G. Jeung, Steven Bandy
  • Patent number: 4960143
    Abstract: A containment housing adapted to be supported on a pipe from which hazardous insulation is to be removed. The housing is composed of two sections pivoted for movement between open and closed positions and has openings at its opposite ends through which the pipe may extend. The joints between the pivoted sections and the pipe-accommodating openings are equipped with seals to prevent insulation particles from escaping the housing. One of the pipe-accommodating openings has an area larger than that of the other to enable the seal at the smaller area opening to engage the bare pipe, whereas the seal at the larger area opening engages the insulation. The housing has an outlet at its bottom through which insulation may pass to a disposable pouch.
    Type: Grant
    Filed: February 12, 1988
    Date of Patent: October 2, 1990
    Assignee: Aerospace America, Inc.
    Inventors: Arthur M. Dore, Jr., Robert M. Sutherland