Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

Abstract: A wellhead assembly includes a containment system having a mechanical barrier, a tertiary wiper, and a fluid jet assembly. A mechanical barrier includes a body disposed in a housing, the body having an opening extending through an axial thickness of the body. A tertiary wiper has an elastomeric body with a hole extending centrally therethrough. A fluid jet assembly includes a jet assembly body having a wall defining a cavity extending axially through the jet assembly body and an array of nozzles positioned circumferentially around the wall, wherein each nozzle has an outlet directed in a radially inward direction from the wall toward a central region in the cavity. The components of the containment system are arranged an axially stacked arrangement relative to each other.

Abstract: A color coordination cone which permits a hair colorist to examine color mixtures before actual application. It is comprised of an internally illuminated cone-shaped base apparatus over which one or more transparent color cones comprised of twenty-four longitudinal color bands in eleven shades is placed. The color cones are rotated one over the other to examine the effect of mixing one color with another. In another embodiment of the invention, a colorless, transparent conical sheath with external tracks in radial planes corresponding to the edges of color cone shade levels is slid over the color cone. Elongated strips in various hues are slid between certain sets of adjacent tracks so that a particular hue on a strip will be positioned over a particular hue on the color cone and the results determined.