Patents by Inventor Robert M. Williams

Robert M. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210269126
    Abstract: A motion absorbing system and method for a structure includes the coupling of a container to a structure. The container has a liquid disposed therein wherein a ullage is defined above a surface of the liquid. An elastic element is positioned in the liquid. The elastic element has a natural frequency tuned to damp motion of the liquid.
    Type: Application
    Filed: May 7, 2021
    Publication date: September 2, 2021
    Applicant: University of Maine System Board of Trustees
    Inventors: Christopher K. Allen, Anthony M. Viselli, Andrew J. Goupee, Habib J. Dagher, Robert E. Berry, Jeffrey L. Lindner, Frederick S. Gant, John S. Townsend, Rebecca L. Williams
  • Patent number: 10738929
    Abstract: An internal boss can have an outer side surface shaped to match the bored opening of the Drain, Waste, and Vent (DWV) pipe, an inner side surface shaped to align with an interior pipe surface of the sanitary Tee or Wye fitting component, and an internal face surface of the boss extending between the side surfaces and shaped to align with an interior pipe surface of the DWV pipe when welded thereto. Snap-fit wings can hold the interior face surface of the sanitary Tee or Wye fitting component against an exterior face surface of the DWV pipe while the fitting component and DWV pipe are homogeneously weldable into a single DWV fitting using a solvent mixture including a common plastic material. Related methods and single homogeneous fittings are also provided.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: August 11, 2020
    Assignee: Delve Holdings, LLC
    Inventor: Robert M. Williams
  • Patent number: 10676504
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: June 9, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
  • Patent number: 10563356
    Abstract: The present invention relates to a method of making a paper product having Improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: February 18, 2020
    Assignee: DOMTAR PAPER COMPANY, LLC
    Inventors: Bruno Marcoccia, Harshad Pande, Robert M. Williams
  • Patent number: 10538534
    Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 21, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
  • Publication number: 20180148895
    Abstract: The present invention relates to a method of making a paper product having Improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Application
    Filed: January 31, 2018
    Publication date: May 31, 2018
    Inventors: Bruno MARCOCCIA, Harshad PANDE, Robert M. WILLIAMS
  • Publication number: 20180087703
    Abstract: An internal boss can have an outer side surface shaped to match the bored opening of the DWV pipe, an inner side surface shaped to align with an interior pipe surface of the sanitary Tee or Wye fitting component, and an internal face surface of the boss extending between the side surfaces and shaped to align with an interior pipe surface of the DWV pipe when welded thereto. Snap-fit wings can hold the interior face surface of the sanitary Tee or Wye fitting component against an exterior face surface of the DWV pipe while the fitting component and DWV pipe are homogeneously weldable into a single DWV fitting using a solvent mixture including a common plastic material. Related methods and single homogeneous fittings are also provided.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 29, 2018
    Applicant: Delve Holdings, LLC
    Inventor: Robert M. WILLIAMS
  • Patent number: 9920484
    Abstract: The present invention relates to a method of making a paper product having improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Assignee: DOMTAR PAPER COMPANY, LLC
    Inventors: Bruno Marcoccia, Harshad Pande, Robert M. Williams
  • Publication number: 20180057510
    Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: March 4, 2016
    Publication date: March 1, 2018
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
  • Publication number: 20180044376
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
  • Patent number: 9844534
    Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: December 19, 2017
    Assignee: Faller & Williams Technology, LLC
    Inventors: Douglas V. Faller, Robert M. Williams
  • Publication number: 20170252322
    Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Application
    Filed: February 6, 2017
    Publication date: September 7, 2017
    Applicant: Faller & Williams Technology, LLC
    Inventors: Douglas V. Faller, Robert M. Williams
  • Patent number: 9650656
    Abstract: The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(?)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: May 16, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Shengying Li, Krithika Anand Srinivasan, Robert M. Williams, David H. Sherman
  • Patent number: 9611491
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: April 4, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ALLEGHENY-SINGER RESEARCH INSTITUTE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Publication number: 20170058457
    Abstract: The present invention relates to a method of making a paper product having improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Application
    Filed: February 20, 2015
    Publication date: March 2, 2017
    Inventors: Bruno Marcoccia, Harshad Pande, Robert M. Williams
  • Patent number: 9572793
    Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: February 21, 2017
    Assignee: Faller & Williams Technology, LLC
    Inventors: Douglas V. Faller, Robert M. Williams
  • Publication number: 20160250183
    Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Application
    Filed: May 6, 2016
    Publication date: September 1, 2016
    Inventors: Douglas V. Faller, Robert M. Williams
  • Patent number: 9364460
    Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 14, 2016
    Inventors: Douglas V. Faller, Robert M. Williams
  • Patent number: 9186402
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: November 17, 2015
    Assignees: Colorado State University Research University, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Publication number: 20150283114
    Abstract: The invention directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevent of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (Ib), (IIa), (IIb), (IIIa), (IIIb), (IVa), (IVb), and (V) as disclosed and described in FIGS. 11 and 12.
    Type: Application
    Filed: September 19, 2013
    Publication date: October 8, 2015
    Inventors: Douglas V. FALLER, Robert M. WILLIAMS