Patents by Inventor Robert M. Williams

Robert M. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200345910
    Abstract: The present disclosure is directed towards systems and methods built for predictively timing the inflation and/or deflation of an intra-aortic balloon pump. A controller operates in three states: (1) initialization state, (2) learning state, and (3) peak detection state. The controller decomposes a patient's electrocardiogram signal to a power signal. It then learns characteristics of the patient's electrocardiogram signal during the learning state and computes adaptive threshold parameter values. During the peak detection state, the controller applies the learnt threshold parameter values on a current electrocardiogram signal to identify occurrence and timings of R peaks in the electrocardiogram signal. The R-to-R peak timings are then used to trigger inflation of an intra-aortic balloon pump.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 5, 2020
    Inventors: Robert M. Smith, Nagarjuna Reddy Chinta, Ryan Daniel McCormick, Douglas Edward Ivers, Cranos M. Williams, Divyakumar Mahiman Badheka, Hubert Troy Nagle, JR., Sai Bhargav Dasari, Shamim Samadi
  • Publication number: 20200270100
    Abstract: Disclosed is a method for retrofitting an elevator machine with a thrust bearing, including removing, from a bearing stand, a first cover plate, providing access to an end portion of a motor shaft, securing an extension shaft against the end portion of the motor shaft, securing a thrust bearing housing against or axially offset from the bearing stand, positioning a thrust bearing in the bearing housing, wherein an inner race of the thrust bearing is securely positioned against, and axially fixed to, the extension shaft, and an outer race of the thrust bearing is securely positioned against the bearing housing, and securing a second cover plate to the bearing housing.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 27, 2020
    Inventors: Daniel B. Davis, III, Robert K. Williams, John Eschenbrenner, Gregory M. O'Seep, James L. Hubbard, Martin J. Hardesty, Bruce P. Swaybill, Jesse R. Richter, Gary P. Mendrala, Patricia Derwinski, Christopher H. Koenig
  • Patent number: 10738929
    Abstract: An internal boss can have an outer side surface shaped to match the bored opening of the Drain, Waste, and Vent (DWV) pipe, an inner side surface shaped to align with an interior pipe surface of the sanitary Tee or Wye fitting component, and an internal face surface of the boss extending between the side surfaces and shaped to align with an interior pipe surface of the DWV pipe when welded thereto. Snap-fit wings can hold the interior face surface of the sanitary Tee or Wye fitting component against an exterior face surface of the DWV pipe while the fitting component and DWV pipe are homogeneously weldable into a single DWV fitting using a solvent mixture including a common plastic material. Related methods and single homogeneous fittings are also provided.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: August 11, 2020
    Assignee: Delve Holdings, LLC
    Inventor: Robert M. Williams
  • Patent number: 10737908
    Abstract: Disclosed is a method for retrofitting an elevator machine with a thrust bearing, including removing, from a bearing stand, a first cover plate, providing access to an end portion of a motor shaft, securing an extension shaft against the end portion of the motor shaft, securing a thrust bearing housing against or axially offset from the bearing stand, positioning a thrust bearing in the bearing housing, wherein an inner race of the thrust bearing is securely positioned against, and axially fixed to, the extension shaft, and an outer race of the thrust bearing is securely positioned against the bearing housing, and securing a second cover plate to the bearing housing.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 11, 2020
    Assignee: OTIS ELEVATOR COMPANY
    Inventors: Daniel B. Davis, III, Robert K. Williams, John Eschenbrenner, Gregory M. O'Seep, James L. Hubbard, Martin J. Hardesty, Bruce P. Swaybill, Jesse R. Richter, Gary P. Mendrala, Patricia Derwinski, Christopher H. Koenig
  • Patent number: 10708374
    Abstract: Techniques for enabling notification from a network resource are described. In at least some embodiments, a user subscribes to receive notifications from a network resource, such as a website, a web-based resource, and so forth. The network resource can provide notifications to a client device of the user, such as a push notification indicating that content is available from the network resource. Based on the push notification, content from the network resource can be presented on the client device, such as in a notification indicator presented on the client device and associated with the network resource.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: July 7, 2020
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Cheuk Wan William Lau, Robert M. Dolin, Larry Jin, Smriti Yamini, Melanie Vanessa Roberts, Lan Tang
  • Publication number: 20200207580
    Abstract: A method is disclosed of retrofitting an elevator machine with primary and secondary braking, the machine being disposed on a machine support frame in an elevator machine room, and engaging one or more ropes for providing selective movement of an elevator car disposed in an elevator shaft, the machine having a drive sheave including a cylindrical brake drum, and brake components including dual brake arms; the method including: removing the brake components; affixing flanged disc segments about the drum and interlocking the flanged disc segments to form a brake rotor; and mounting respective brake calipers to frame mounts for providing primary and secondary braking to the elevator machine.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Daniel B. Davis, III, Robert K. Williams, John Eschenbrenner, Gregory M. O'Seep, James L. Hubbard, Martin J. Hardesty, Bruce P. Swaybill, Jesse R. Richter, Gary P. Mendrala, Patricia Derwinski, Christopher H. Koenig
  • Patent number: 10685657
    Abstract: Systems and methods for analyzing digital recordings of the human voice in order to find characteristics unique to an individual. A biometrics engine may use an analytics service in a contact center to supply audio streams based on configured rules and providers for biometric detection. The analytics service may provide call audio data and attributes to connected engines based on a provider-set of selection rules. The connected providers send call audio data and attributes through the analytics service. The engines are notified when a new call is available for processing and can then retrieve chunks of audio data and call attributes by polling an analytics service interface. A mathematical model of the human vocal tract in the call audio data is created and/or matched against existing models. The result is analogous to a fingerprint, i.e., a pattern unique to an individual to within some level of probability.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 16, 2020
    Assignee: VERINT AMERICAS INC
    Inventors: Jamie Richard Williams, Robert John Barnes, Ian Linsdell, Scott M. Bluman
  • Patent number: 10676504
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: June 9, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
  • Patent number: 10617650
    Abstract: The present invention provides a process for preparing enterically-coated lyospheres comprising a therapeutic agent comprising: a.) providing lyospheres comprising the therapeutic agent; b.) coating said lyospheres with an enteric polymer coating composition; and c.) isolating said enterically-coated lyospheres. In other embodiments, the invention provides dosage forms comprising a lyosphere comprising an effective amount of a therapeutic agent and an enteric polymer coating. In some embodiments, the therapeutic agent in the process or dosage form is a polypeptide, a protein, a peptide, a lipopeptide, a glycoprotein, a fusion protein, a protein conjugate, a cytokine, an enzyme, an antibody, an oligonucleotide, a vaccine vector, small molecule, a live virus, an inactivated virus, a virus-like particle, a viral protein subunit, an adjuvant, microbiome, a prebiotic, a probiotic, or an ectobiotic.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: April 14, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Akhilesh Bhambhani, Robert K. Evans, Pranav Gupta, Ronald L. Smith, Donna M. Williams
  • Patent number: 10618775
    Abstract: A method is disclosed of retrofitting an elevator machine with primary and secondary braking, the machine being disposed on a machine support frame in an elevator machine room, and engaging one or more ropes for providing selective movement of an elevator car disposed in an elevator shaft, the machine having a drive sheave including a cylindrical brake drum, and brake components including dual brake arms; the method including: removing the brake components; affixing flanged disc segments about the drum and interlocking the flanged disc segments to form a brake rotor; and mounting respective brake calipers to frame mounts for providing primary and secondary braking to the elevator machine.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: April 14, 2020
    Assignee: OTIS ELEVATOR COMPANY
    Inventors: Daniel B. Davis, III, Robert K. Williams, John Eschenbrenner, Gregory M. O'Seep, James L. Hubbard, Martin J. Hardesty, Bruce P. Swaybill, Jesse R. Richter, Gary P. Mendrala, Patricia Derwinski, Christopher H. Koenig
  • Patent number: 10611600
    Abstract: An illustrative example elevator system includes an elevator car and a valve assembly that selectively directs fluid flow to control movement of the elevator car. At least one sensor provides an indication of a current status of the elevator car, which includes at least a position of the elevator car or a speed of the elevator car. A processor receives the indication from the at least one sensor and adjusts operation of the valve assembly when the current status of the elevator car is different than a predetermined desired status.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: April 7, 2020
    Assignee: OTIS ELEVATOR COMPANY
    Inventors: Matthew Sean Morrison, Robert K. Williams, Gregory M. O'Seep
  • Patent number: 10563356
    Abstract: The present invention relates to a method of making a paper product having Improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: February 18, 2020
    Assignee: DOMTAR PAPER COMPANY, LLC
    Inventors: Bruno Marcoccia, Harshad Pande, Robert M. Williams
  • Patent number: 10538534
    Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 21, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
  • Publication number: 20190348049
    Abstract: Systems and methods for analyzing digital recordings of the human voice in order to find characteristics unique to an individual. A biometrics engine may use an analytics service in a contact center to supply audio streams based on configured rules and providers for biometric detection. The analytics service may provide call audio data and attributes to connected engines based on a provider-set of selection rules. The connected providers send call audio data and attributes through the analytics service. The engines are notified when a new call is available for processing and can then retrieve chunks of audio data and call attributes by polling an analytics service interface. A mathematical model of the human vocal tract in the call audio data is created and/or matched against existing models. The result is analogous to a fingerprint, i.e., a pattern unique to an individual to within some level of probability.
    Type: Application
    Filed: February 15, 2019
    Publication date: November 14, 2019
    Inventors: Jamie Richard Williams, Robert John Barnes, Ian Linsdell, Scott M. Bluman
  • Patent number: 10415143
    Abstract: The present invention provides a method for the production in an electrochemical cell of one or more of graphene, graphite nanoplatelet structures having a thickness of less than 100 nm, and graphane, wherein the cell comprises: (a) a negative electrode which is graphitic; (b) a positive electrode which may be graphitic or another material; and (c) an electrolyte selected from (i) an ionic liquid; (ii) a deep eutectic solvent; and (iii) a solid ionic conductor, optionally further comprising (iv) one or more ionic species, wherein the amount of (i), (ii) or (iii) and (iv) is greater than 50 wt % based on the total weight of the electrolyte; and wherein the electrolyte includes a mixture of different cations; and wherein the method comprises the step of passing a current through the cell to intercalate ions into the graphitic negative electrode so as to exfoliate the graphitic negative electrode.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: September 17, 2019
    Assignee: The University of Manchester
    Inventors: Robert Angus William Dryfe, Ian Anthony Kinloch, Amr M. Abdelkader
  • Publication number: 20180148895
    Abstract: The present invention relates to a method of making a paper product having Improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Application
    Filed: January 31, 2018
    Publication date: May 31, 2018
    Inventors: Bruno MARCOCCIA, Harshad PANDE, Robert M. WILLIAMS
  • Publication number: 20180087703
    Abstract: An internal boss can have an outer side surface shaped to match the bored opening of the DWV pipe, an inner side surface shaped to align with an interior pipe surface of the sanitary Tee or Wye fitting component, and an internal face surface of the boss extending between the side surfaces and shaped to align with an interior pipe surface of the DWV pipe when welded thereto. Snap-fit wings can hold the interior face surface of the sanitary Tee or Wye fitting component against an exterior face surface of the DWV pipe while the fitting component and DWV pipe are homogeneously weldable into a single DWV fitting using a solvent mixture including a common plastic material. Related methods and single homogeneous fittings are also provided.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 29, 2018
    Applicant: Delve Holdings, LLC
    Inventor: Robert M. WILLIAMS
  • Patent number: 9920484
    Abstract: The present invention relates to a method of making a paper product having improved printing characteristics. This is achieved by forming a fibrous substrate, and applying a surface treatment which comprises an aqueous composition. Notably, the aqueous composition includes surface enhanced pulp fibers, with the placement of the surface enhanced pulp fibers optimizing their functionality, with surface placement by use of a paper machine size press desirably facilitating a reduction in the typical starch usage. The present method comprising the steps of providing a aqueous slurry comprising a blend of cellulosic fibers and water and dewatering the aqueous slurry of cellulosic fibers and water to form a fibrous substrate.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Assignee: DOMTAR PAPER COMPANY, LLC
    Inventors: Bruno Marcoccia, Harshad Pande, Robert M. Williams
  • Publication number: 20180057510
    Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: March 4, 2016
    Publication date: March 1, 2018
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
  • Publication number: 20180044376
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra