Abstract: An embolic coil is formed from a continuous wire and has a primary shape formed by winding the wire on a tapered mandrel such that the primary shape of the coil is a spiral having an outer diameter that increases from a first outer diameter at the proximal end to a second outer diameter at the distal end that is larger than the first outer diameter. The coil has the primary shape when constrained within a delivery catheter. The coil has a gradient stiffness profile transitioning from a first stiffness at the proximal end to a second stiffness at the distal end that is less than the first stiffness. The coil has a secondary shape after exiting the delivery catheter that includes at least one loop or fold formed from the spiral of the primary shape.

Abstract: An embolic coil includes a single wire formed into a primary coil and then forming the primary coil into a secondary coil having a distal section and a proximal section, where the distal section of the secondary coil has a first stiffness and the proximal section has a second stiffness less than the first stiffness. The wire has a constant diameter along an entirety of its length and the primary coil has a constant diameter along an entirety of its length. A difference in stiffness between the distal and proximal sections is created by selective infrared heat treatment of the wire.

Abstract: Embodiments herein relate to devices for delivering fluid-based therapies into a target vessel of a patient. In an embodiment, an apparatus is included having a microcatheter. The microcatheter can include a catheter shaft having a lumen therein. The microcatheter can have an open end that is at a distal end of the catheter shaft. The microcatheter can have a plurality of side apertures disposed within a side wall of the catheter shaft. The plurality of side apertures allow for a fluid to pass from the lumen to the outside of the catheter shaft. The apparatus further includes a seal element configured to pass through the lumen of the microcatheter. The seal element can include a shaft and an occlusion member configured to at least partially occlude the open end of the microcatheter directing fluid flow through the plurality of side apertures. Other embodiments are also included herein.

Abstract: Embodiments herein relate to systems for generating therapeutic suspensions of microspheres and carrier fluid that include a tumbling or rotating container. In an embodiment, a cancer therapy delivery system is included having a tumbler vial, the tumbler vial defining an interior volume. The system also includes a rotation mechanism configured to rotate the tumbler vial, a fluid inlet in fluid communication with the interior volume, a fluid outlet in fluid communication with the interior volume, a fluid inlet line connected to the fluid inlet, a fluid outlet line connected to the fluid outlet, a cap, wherein the fluid inlet and the fluid outlet pass through the cap and wherein the cap occludes an end of the tumbler vial. The fluid inlet line and the fluid outlet line can be configured to twist as the tumbler vial is rotated. Other embodiments are also included herein.

Abstract: A medical assembly includes an implantable medical device and an elongate delivery member that is adapted to deliver the implantable medical device. The implantable medical device is releasably secured to the elongate delivery member. An outer sheath is adapted to fit over the elongate delivery member. A removable coupler is adapted to secure the elongate delivery member in position relative to the outer sheath when the removable coupler is disposed between the elongate delivery method and the outer sheath.

Abstract: Embodiments herein relate to catheter connection manifold bypass devices, cancer therapy delivery systems, and related methods. For example, a catheter connection manifold bypass device can be included having a fluid passage conduit with a proximal end and a distal end. The bypass device can also include a deformable tip disposed around the distal end of the fluid passage conduit. The deformable tip can fit within a distal portion of a cavity within a connection manifold for a fluid delivery catheter. The bypass device can include a proximal connection port that can be connected to the proximal end of the fluid passage conduit. The bypass device can also include a connection adapter defining a channel, wherein the fluid passage conduit passes through the channel. The distal end of the connection adapter can be configured to attach to a proximal end of the fluid delivery catheter. Other embodiments are also included herein.

Abstract: An adaptor for modifying pre-existing delivery system to improve delivery of an injectable treatment material through the delivery system. The delivery system is a pre-existing delivery system formed separately and without regard to the manufacture of the adaptor. The delivery system includes an administration set and a catheter set coupled together in fluid communication via a manifold. The injectable treatment material may be in the form of microspheres or microbeads which may become held up within the void space of the pre-existing manifold of the delivery system. The adaptor reconfigures the interior of the manifold to facilitate complete flow of the injectable treatment material therethrough without getting hung up or otherwise caught within the manifold and not delivered to a patient.

Abstract: A catheter includes an elongated tubular shaft having a distal end, a proximal end, and a lumen extending therethrough. The elongated tubular shaft includes a polymeric outer layer, a polymeric inner layer, and a braided middle layer. A marker band is positioned adjacent the distal end of the elongated tubular shaft and may surround the middle layer, and a polymeric distal tip is attached to the distal end of the elongated tubular shaft. A distal end of the outer layer terminates proximal to the marker band such that the middle layer includes an exposed region that is exposed from the outer layer between the distal end of the outer layer and a proximal end of the marker band, and the distal tip is formed over the exposed region of the middle layer and the marker band, and extends distally beyond the distal end of the elongated tubular shaft.

Abstract: A medical device system includes an elongate sheath defining a lumen extending within the elongate sheath. A coupler mechanism is slidingly disposed within the lumen, the coupler mechanism including a proximal coupler and a distal coupler. An elongate member is secured to and extends proximally from the proximal coupler. An implantable medical device (IMD) is secured to and extends distally from the distal coupler. The distal coupler remains secured to the proximal coupler while the coupler mechanism remains within the lumen, and the distal coupler releases from the proximal coupler, thereby releasing the IMD, when the coupler mechanism is exterior to the lumen.

Abstract: Medical devices and methods are disclosed in the present application. In one illustrative example a medical device may comprise a catheter shaft extending from a proximal end to a distal end and the catheter shaft may include a plurality of catheter shaft lumens extending through at least a portion of the catheter shaft. The device may further include a first balloon member defining a first lumen in fluid communication with a first one of the plurality of catheter shaft lumens and a second balloon member defining a second lumen in fluid communication with a second one of the plurality of catheter shaft lumens. In some embodiments, the second balloon member may be disposed around the first balloon member and comprise a plurality of ports and a first raised portion and a second raised portion.