Patents by Inventor Robert Mandell

Robert Mandell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20210269511
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: September 16, 2020
    Publication date: September 2, 2021
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20180208643
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20160152694
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: October 29, 2015
    Publication date: June 2, 2016
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 9217029
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 22, 2015
    Assignees: UNIVERSITY OF MASSACHUSETTS, E. R. SQUIBB & SONS, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF
    Publication number: 20150315266
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: December 2, 2014
    Publication date: November 5, 2015
    Inventors: William D. Thomas, JR., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20140120614
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 1, 2014
    Applicants: MEDAREX, L.L.C., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 8609111
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 17, 2013
    Assignees: University of Massachusetts, Medarex, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF
    Publication number: 20130039926
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: July 19, 2012
    Publication date: February 14, 2013
    Applicants: Center for Disease Control and Prevention, University of Massachusetts
    Inventors: William D. Thomas, JR., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20120288508
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: June 7, 2012
    Publication date: November 15, 2012
    Applicants: MEDAREX, INC., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against toxins and uses thereof
    Patent number: 8257709
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: September 4, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Antibodies against clostridium difficile toxins and uses thereof
    Patent number: 8236311
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: August 7, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Human antibodies against rabies and uses thereof
    Patent number: 8226952
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: July 24, 2012
    Assignees: University of Massachusetts, Centers for Disease Control and Prevention
    Inventors: William D. Thomas, Jr., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF
    Publication number: 20110008360
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: April 26, 2010
    Publication date: January 13, 2011
    Applicants: UNIVERSITY OF MASSACHUSETTS, CENTERS FOR DISEASE CONTROL AND PREVENTION
    Inventors: William D. THOMAS, JR., Donna M. AMBROSINO, Robert MANDELL, Susan SLOAN, Gregory J. BABCOCK, Charles RUPPRECHT
  • ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
    Publication number: 20100233181
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: July 31, 2009
    Publication date: September 16, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, MEDAREX, INC.
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Antibodies against Clostridium difficile toxins and uses thereof
    Publication number: 20100233182
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: July 31, 2009
    Publication date: September 16, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, MEDAREX, INC.
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Human antibodies against rabies and uses thereof
    Patent number: 7727532
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: June 1, 2010
    Assignees: University of Massachusetts, Centers for Disease Control and Prevention
    Inventors: William D. Thomas, Jr., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • Antibodies against toxins and uses thereof
    Patent number: 7625559
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: December 1, 2009
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • MOMLV-BASED PSEUDOVIRION PACKAGING CELL LINE
    Publication number: 20090123494
    Abstract: The present invention discloses Moloney murine leukemia virus (MoMLV)-based viral packaging cell line for the production of anti-viral vaccines. The invention also includes methods of making, administering and formulating pseudovirions and replicon deficient viral particles of the invention and methods of inducing immunity.
    Type: Application
    Filed: July 31, 2008
    Publication date: May 14, 2009
    Inventors: William Staplin, Robert Mandell, Ramon Flick
  • Human antibodies against rabies and uses thereof
    Publication number: 20090041777
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: August 2, 2007
    Publication date: February 12, 2009
    Inventors: William D. Thomas, JR., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • Antibodies against Clostridium difficile toxins and uses thereof
    Publication number: 20050287150
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: February 4, 2005
    Publication date: December 29, 2005
    Applicants: UNIVERSITY OF MASSACHUSETTS, MEDAREX, INC.
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Robert Graziano, Hector Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William Thomas, Hui-Fen Zhang