Abstract: Disclosed is a device including at least 4 sections with a unique layout which includes a surface functionalized with an agent having specific binding affinity to a target molecule, and which allows flow. Disclosed are also a kit and a method for determining and quantifying the presence of a biomarker of a thyroid medical condition in a sample.

Abstract: Disclosed is a device including at least 4 sections with a unique layout which includes a surface functionalized with an agent having specific binding affinity to a target molecule, and which allows lateral flow. Disclosed are also a kit and a method for determining and quantifying the presence of an analyte in a sample.

Abstract: Methods for managing digital content are provided. In one aspect, a method includes receiving a succession plan request from a first user device to initiate a succession plan to designate ownership rights to digital content owned by an owner associated with the first user device and an owner account. The method includes receiving succession information of at least one successor. The method includes determining whether payment associated with the owner account is missed. The method includes transmitting, in response to determining that payment is missed, a notification to the first user device notifying the owner that payment is missed. The method includes archiving the digital content. The method includes transmitting a first communication to the at least one successor to accept ownership of the digital content. The method includes designating ownership of the digital content to the at least one successor. System and machine-readable media are also provided.

Abstract: Disclosed is a device including at least a section 1, a section 2, a section 3 and a section 4 wherein section 2 is coupled to section 1, section 3 is coupled to section 2 and comprises a surface functionalized with an analyte or equivalent thereof, section 4 is coupled to section 3, and section 1, section 2, section 3 and section 4 are arranged along a horizontal axis and in fluid communication allowing lateral flow from section 1 throughout all sections to section 4. Disclosed are also a kit and method for determining and quantifying the presence of an analyte in a sample.

Abstract: The present invention provides for the incorporation of target sequences of microRNAs into the 3?UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an expression system comprising such vectors, a pharmaceutical composition comprising such vectors, as well as methods of treating or preventing cardiovascular disease by using such vectors.

Abstract: An automated payment system is disclosed. The automated payment system comprises a housing, a door coupled to the housing, wherein the door covers a side of the housing when in a closed position, a payment apparatus within an interior of the housing, the payment apparatus fixedly coupled to an extendable base, wherein the extendable base is slidably coupled to the housing and configured to extend out from within the housing and through the side when the door is in an open position, and a handle coupled to the door, the handle operable, when the door is in the open position, to contact the ground to provide additional support for the weight of the payment apparatus.

Abstract: An automated payment system is disclosed. The automated payment system comprises a housing, a door coupled to the housing, wherein the door covers a side of the housing when in a closed position, a payment apparatus within an interior of the housing, the payment apparatus fixedly coupled to an extendable base, wherein the extendable base is slidably coupled to the housing and configured to extend out from within the housing and through the side when the door is in an open position, and a handle coupled to the door, the handle operable, when the door is in the open position, to contact the ground to provide additional support for the weight of the payment apparatus.

Abstract: The present invention provides for the incorporation of target sequences of microRNAs into the 3?UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an expression system comprising such vectors, a pharmaceutical composition comprising such vectors, as well as methods of treating or preventing cardiovascular disease by using such vectors.

Abstract: The present invention provides for the incorporation of target sequences of microRNAs into the 3? UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an expression system comprising such vectors, a pharmaceutical composition comprising such vectors, as well as methods of treating or preventing cardiovascular disease by using such vectors.

Abstract: Prioritization of data traffic is a common technique for providing enhanced quality of service (QoS), allowing some traffic to reach its destination on an expedited basis without being obstructed or delayed by other lower-priority traffic. A mechanism is disclosed using the bearer architecture of the evolved packet core (EPC) to provide prioritization of traffic from specific packet data networks (PDNs), as well as over specific bearers. The priority information is requested by the mobile management entity (MME), which is commonly overloaded with traffic to and from multiple users and PDNs. In addition, a mechanism is provided for reducing the frequency of unwanted paging notifications for MMEs that are overloaded.

Abstract: Methods for reducing toxicity or side effects caused by administration of a rycal compound for repairing ryanodine receptor channel leaks when treating a disorder in a subject caused by such leaks. These methods are based upon the selection for administration of those rycal compounds having properties including an EC50 value of 102 nM when assayed for its ability to facilitate the rebinding of FKBP12.6 to PKA-phosphorylated RyR2 or less and less than 50% inhibition of the hERG K+ channel (IKr) when administered at 10 ?M to reduce compound toxicity or side effects after administration compared to other rycal compounds not having those properties.

Abstract: The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

Abstract: Methods and systems for providing interconnection between network operation environments are disclosed in some embodiments. This can include providing interoperability between 3GPP and 3GPP2 standards environments. In one embodiment, a method is disclosed that includes receiving a request from a mobile device for service at a gateway, determining a mode of operation for the mobile device by inspecting an incoming message, wherein the mode of operation includes 3GPP and 3GPP2, establishing a connection using a proxy mobile internet protocol (PMIP), where the type of connection established is dependent on the mode of operation, providing an IP address to a mobile device based on the mode of operation and the parameters associated with the mode of operation, and communicating with an authentication, authorization, and accounting (AAA) server operating in accordance with the mode of operation.

Abstract: Prioritization of data traffic is a common technique for providing enhanced quality of service (QoS), allowing some traffic to reach its destination on an expedited basis without being obstructed or delayed by other lower-priority traffic. A mechanism is disclosed using the bearer architecture of the evolved packet core (EPC) to provide prioritization of traffic from specific packet data networks (PDNs), as well as over specific bearers. The priority information is requested by the mobile management entity (MME), which is commonly overloaded with traffic to and from multiple users and PDNs. In addition, a mechanism is provided for reducing the frequency of unwanted paging notifications for MMEs that are overloaded.

Abstract: The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome.

Abstract: The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

Abstract: Methods and systems for providing interconnection between network operation environments are disclosed in some embodiments. This can include providing interoperability between 3GPP and 3GPP2 standards environments. In one embodiment, a method is disclosed that includes receiving a request from a mobile device for service at a gateway, determining a mode of operation for the mobile device by inspecting an incoming message, wherein the mode of operation includes 3GPP and 3GPP2, establishing a connection using a proxy mobile internet protocol (PMIP), where the type of connection established is dependent on the mode of operation, providing an IP address to a mobile device based on the mode of operation and the parameters associated with the mode of operation, and communicating with an authentication, authorization, and accounting (AAA) server operating in accordance with the mode of operation.

Abstract: The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.