Abstract: A cable guide assembly for a rail vehicle for guiding at least one cable from a first vehicle part to a second vehicle part coupled to the first vehicle part includes a first stabilization device mounted on the first vehicle part and the at least one cable. The first stabilization part is deformable in a first guiding duration and rigid perpendicular thereto. The first stabilization part is coupled to a first cable section of the cable such that the deformability of the first stabilization device permits movement of the first cable section in the first guiding direction and blocks movement perpendicular thereto.

Abstract: The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation.

Abstract: The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation.

Abstract: The present invention is a method for inhibiting or reducing disease progression in subjects suffering from conditions or diseases related to the A? peptide, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like. The method comprises admininstering an apoE2 lentiviral vector to the subject.

Abstract: This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs, lentiviral packaging systems, and lentiviral gene delivery systems. Finally, methods of transducing a cell and methods of targeting a gene to a cell or tissue using the disclosed lentiviral vectors and systems are also provided.

Abstract: The invention provides a lentiviral vector containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided is a lentiviral packaging construct. The construct contains a nucleic acid encoding trans-acting factors sufficient for lentiviral vector generation and an attachment incompetent fusogenic polypeptide. A lentiviral packaging system having at least two nucleic acid vectors is further provided. The lentiviral packaging system consists of a first nucleic acid vector comprising a packaging construct encoding a trans-acting factor for lentiviral vector generation, and a second nucleic acid vector encoding an attachment incompetent fusogenic polypeptide, said at least two vectors together encoding trans-acting factors sufficient for lentiviral vector generation. The invention additionally provides a lentiviral gene delivery system having at least three nucleic acid vectors.

Abstract: Fouling of the convection section of a steam generator by ash or other solid deposit from the product gas stream is monitored using radiation pyrometers which determine the temperature drop across a bank of heat exchanger tubes and calculation therefrom of a fouling factor related to the degree of fouling. Soot blowers are actuated, in manual response or automatic response, to the fouling factor, to effect cleaning of the heat exchanger tubes. Heat flux meters also may be provided to determine variations in the degree of fouling transverse to the flow of the gas stream and the determinations may be used to actuate selective cleaning of parts of the tube bank.

Abstract: Fouling of the convection section of a steam generator by ash or other solid deposit from the product gas stream is monitored using radiation pyrometers which determine the temperature drop across a bank of heat exchanger tubes and calculation therefrom of a fouling factor related to the degree of fouling. Soot blowers are actuated, in manual response or automatic response, to the fouling factor, to effect cleaning of the heat exchanger tubes. Heat flux meters also may be provided to determine variations in the degree of fouling transverse to the flow of the gas stream and the determinations may be used to actuate selective cleaning of parts of the tube bank.

Abstract: Fouling of the convection section of a steam generator by ash or other solid deposit from the product gas stream is monitored using radiation pyrometers which determine the temperature drop across a bank of heat exchanger tubes and calculation therefrom of a fouling factor related to the degree of fouling. Soot blowers are actuated, in manual response or automatic response, to the fouling factor, to effect cleaning of the heat exchanger tubes. Heat flux meters also may be provided to determine variations in the degree of fouling transverse to the flow of the gas stream and the determinations may be used to actuate selective cleaning of parts of the tube bank.

Abstract: Fouling of the convection section of a steam generator by ash or other solid deposit from the product gas stream is monitored using radiation pyrometers which determine the temperature drop across a bank of heat exchanger tubes and calculation therefrom of a fouling factor related to the degree of fouling. Soot blowers are actuated, in manual response or automatic response, to the fouling factor, to effect cleaning of the heat exchanger tubes. Heat flux meters also may be provided to determine variations in the degree of fouling transverse to the flow of the gas stream and the determinations may be used to actuate selective cleaning of parts of the tube bank.