Patents by Inventor Robert Marrero

Robert Marrero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multilayered microfluidic DNA analysis system and method
    Patent number: 6984516
    Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: January 10, 2006
    Assignee: Motorola, Inc.
    Inventors: Cynthia G. Briscoe, Huinan Yu, Piotr Grodzinski, Robert Marrero, Jeremy W. Burdon, Rong-Fong Huang
  • Compositions and methods for rolling circle amplification
    Publication number: 20040014078
    Abstract: This invention is directed to novel methods of amplifying and detecting DNA. More specifically, the invention applies variations of Rolling Circle Amplification to several detection platforms.
    Type: Application
    Filed: February 6, 2003
    Publication date: January 22, 2004
    Inventors: James Xia, Charles K. Brush, Vineet Gupta, Heshu Huang, Changming Li, George Maracas, Robert Marrero, Melissa L. Ray, Lei Sun, Peiming Zhang
  • Microfluidic devices with monolithic microwave integrated circuits
    Patent number: 6605454
    Abstract: A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The microwave radiation from the MMIC is useful for heating samples introduced into the microfluidic structure and for effecting lysis of cells in the samples. Microfabrication techniques allow the fabrication of MMICs that perform heating and cell lysing of samples having volumes in the microliter to picoliter range.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: August 12, 2003
    Assignee: Motorola, Inc.
    Inventors: Barbara Foley Barenburg, Jeremy Burdon, Yuk-Tong Chan, Xunhu Dai, Sean Gallagher, Piotr Grodzinski, Robert Marrero, Vijay Nair, David Rhine, Thomas Smekal
  • Multilayered microfluidic DNA analysis system and method
    Publication number: 20030129646
    Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.
    Type: Application
    Filed: January 10, 2003
    Publication date: July 10, 2003
    Inventors: Cynthia G. Briscoe, Huinan Yu, Piotr Grodzinski, Robert Marrero, Jeremy W. Burdon, Rong-Fong Huang
  • Integrated multilayered microfludic devices and methods for making the same
    Patent number: 6572830
    Abstract: A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: June 3, 2003
    Assignee: Motorola, Inc.
    Inventors: Jeremy W. Burdon, Rong-Fong Huang, David Wilcox, Nicholas J. Naclerio, Cynthia Ann Gorsuch Briscoe, Piotr Grodzinski, Huinan Yu, Robert Marrero, Sean Ross Gallagher, Yuk-Tong Chan, Barbara McNeil Foley, Xunhu Dai
  • Multilayered microfluidic DNA analysis system and method
    Patent number: 6544734
    Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: April 8, 2003
    Inventors: Cynthia G. Briscoe, Huinan Yu, Piotr Grodzinski, Robert Marrero, Jeremy W. Burdon, Rong-Fong Huang
  • Microfluidic devices with monolithic microwave integrated circuits
    Publication number: 20020115201
    Abstract: A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The microwave radiation from the MMIC is useful for heating samples introduced into the microfluidic structure and for effecting lysis of cells in the samples. Microfabrication techniques allow the fabrication of MMICs that perform heating and cell lysing of samples having volumes in the microliter to picoliter range.
    Type: Application
    Filed: March 22, 2001
    Publication date: August 22, 2002
    Inventors: Barbara Foley Barenburg, Jeremy Burdon, Yuk-Tong Chan, Xunhu Dai, Sean Gallagher, Piotr Grodzinski, Robert Marrero, Vijay Nair, David Rhine, Thomas Smekal