Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ECG signals are sensed. A processor may evaluate the channels by analyzing their respective ECG signals, to determine which contains less noise than the other(s). The analysis can be by extracting statistics from the ECG signals, optionally after first processing them, and then by comparing these statistics. These statistics may include tall peak counts, amplitudes of peaks compared to historical peak amplitudes, signal baseline shift, dwell time near a baseline, narrow peak counts, zero crossings counts, determined heart rates, and so on. Once the less noisy signal is identified, its channel can be followed preferentially or to the exclusion of other channels, for continuing monitoring and/or determining whether to shock the patient.

Abstract: A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ECG signals are sensed. A processor may evaluate the channels by analyzing their respective ECG signals, to determine which contains less noise than the other(s). The analysis can be by extracting statistics from the ECG signals, optionally after first processing them, and then by comparing these statistics. These statistics may include tall peak counts, amplitudes of peaks compared to historical peak amplitudes, signal baseline shift, dwell time near a baseline, narrow peak counts, zero crossings counts, determined heart rates, and so on. Once the less noisy signal is identified, its channel can be followed preferentially or to the exclusion of other channels, for continuing monitoring and/or determining whether to shock the patient.

Abstract: A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ECG signals are sensed. A processor may evaluate the channels by analyzing their respective ECG signals, to determine which contains less noise than the other(s). The analysis can be by extracting statistics from the ECG signals, optionally after first processing them, and then by comparing these statistics. These statistics may include tall peak counts, amplitudes of peaks compared to historical peak amplitudes, signal baseline shift, dwell time near a baseline, narrow peak counts, zero crossings counts, determined heart rates, and so on. Once the less noisy signal is identified, its channel can be followed preferentially or to the exclusion of other channels, for continuing monitoring and/or determining whether to shock the patient.

Abstract: A double lead interference screw useful for securing a soft tissue graft inside a bone tunnel of a bone mass is disclosed. The interference screw has continuous independent double threads having uniform pitch, helix angle, and crest height throughout the threaded portions of the screw; a bulbous head; a threaded proximal section with a cylindrical root, a threaded distal section with a tapered root, and a threaded tapered distal tip. Methods for soft tissue repair using the double lead interference screw are also disclosed.

Abstract: The invention relates to a catalyst arrangement for preparing phthalic anhydride by gas-phase oxidation of aromatic hydrocarbons, which comprises a reactor having a gas inlet end for a feed gas and a gas outlet end for a product gas and also a first catalyst zone made up of catalyst bodies and at least one second catalyst zone made up of catalyst bodies, where the first catalyst zone is arranged at the gas inlet end and the second catalyst zone is arranged downstream of the first catalyst zone in the gas flow direction and the length of the first catalyst zone in the gas flow direction is less than the length of the second catalyst zone in the gas flow direction, characterized in that the first catalyst zone has a higher gap content compared to the second catalyst zone.

Abstract: Embodiments operate in contexts where field data have been generated from a field event, and annotations have been generated from the field data, which purport to identify events within the field data, such as CPR compressions and ventilations. Metrics are generated from the annotations, which are used in training. In such contexts, a grade may be assigned that reflects how well the annotations meet one or more accuracy criteria. The grade may be used in a number of ways. Reviewers may opt to disregard field data and metrics that have a low grade. Expert annotators may be guided as to precisely which annotations to revise, saving time. A low grade may decide that the results are not emailed to reviewers, but to annotators. A learning medical device can use the grade internally to adjust its own internal parameters so as to improve its annotating algorithms.

Abstract: A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ECG signals are sensed. A processor may evaluate the channels by analyzing their respective ECG signals, to determine which contains less noise than the other(s). The analysis can be by extracting statistics from the ECG signals, optionally after first processing them, and then by comparing these statistics. These statistics may include tall peak counts, amplitudes of peaks compared to historical peak amplitudes, signal baseline shift, dwell time near a baseline, narrow peak counts, zero crossings counts, determined heart rates, and so on. Once the less noisy signal is identified, its channel can be followed preferentially or to the exclusion of other channels, for continuing monitoring and/or determining whether to shock the patient.

Abstract: The invention relates to a catalyst arrangement for preparing phthalic anhydride by gas-phase oxidation of aromatic hydrocarbons, which comprises a reactor having a gas inlet end for a feed gas and a gas outlet end for a product gas and also a first catalyst zone made up of catalyst bodies and at least one second catalyst zone made up of catalyst bodies, where the first catalyst zone is arranged at the gas inlet end and the second catalyst zone is arranged downstream of the first catalyst zone in the gas flow direction and the length of the first catalyst zone in the gas flow direction is less than the length of the second catalyst zone in the gas flow direction, characterized in that the first catalyst zone has a higher gap content compared to the second catalyst zone.

Abstract: A technology for producing synthesis gas from crude gas from various gasification processes for solid or liquid fuels. To limit the temperatures in a subsequent strongly exothermic CO shift reaction to adjust the H2/CO ratio, the crude gas which has been freed of dust flows through two shift reactors arranged in series. The first reactor has a specific reaction-kinetically limited catalyst and the second reactor has a conventional sour gas catalyst. The specific catalyst used in the first reactor limits the exothermic shift reaction to such an extent that the reaction temperatures in the first and second reactors remain so low to avoid thermal damage to the catalysts even without introduction of external steam, and the desired gas composition is achieved.

Abstract: An external medical device can include a housing and a processor within the housing. The processor can be configured to receive an input signal for a patient receiving chest compressions from a mechanical chest compression device. The processor can also be configured to select at least one filter mechanism, the mechanical chest compression device having a chest compression frequency f. The processor can be further configured to apply the at least one filter mechanism to the signal to at least substantially remove chest compression artifacts from the signal, wherein the chest compression artifacts correspond to the chest compressions being delivered to the patient by the mechanical chest compression device, and wherein the at least one filter mechanism substantially rejects content in the frequency f plus content in at least one more frequency that is a higher harmonic to the frequency f.

Abstract: A technology for producing synthesis gas from crude gas from various gasification processes for solid or liquid fuels. To limit the temperatures in a subsequent strongly exothermic CO shift reaction to adjust the H2/CO ratio, the crude gas which has been freed of dust flows through two shift reactors arranged in series. The first reactor has a specific reaction-kinetically limited catalyst and the second reactor has a conventional sour gas catalyst. The specific catalyst used in the first reactor limits the exothermic shift reaction to such an extent that the reaction temperatures in the first and second reactors remain so low to avoid thermal damage to the catalysts even without introduction of external steam, and the desired gas composition is achieved.

Abstract: Embodiments operate in contexts where field data have been generated from a field event, and annotations have been generated from the field data, which purport to identify events within the field data, such as CPR compressions and ventilations. Metrics are generated from the annotations, which are used in training. In such contexts, a grade may be assigned that reflects how well the annotations meet one or more accuracy criteria. The grade may be used in a number of ways. Reviewers may opt to disregard field data and metrics that have a low grade. Expert annotators may be guided as to precisely which annotations to revise, saving time. A low grade may decide that the results are not emailed to reviewers, but to annotators. A learning medical device can use the grade internally to adjust its own internal parameters so as to improve its annotating algorithms.

Abstract: An external medical device can include a housing and a processor within the housing. The processor can be configured to receive an input signal for a patient receiving chest compressions from a mechanical chest compression device. The processor can also be configured to select at least one filter mechanism, the mechanical chest compression device having a chest compression frequency f. The processor can be further configured to apply the at least one filter mechanism to the signal to at least substantially remove chest compression artifacts from the signal, wherein the chest compression artifacts correspond to the chest compressions being delivered to the patient by the mechanical chest compression device, and wherein the at least one filter mechanism substantially rejects content in the frequency f plus content in at least one more frequency that is a higher harmonic to the frequency f.

Abstract: A fencing match is simulated by a card game that includes a plurality of action cards and a plurality of judgment cards. Each action card includes an indication of a movement distance, a reach distance and a relative strength of an action. Each judgment card includes an indication of a successful play, an unsuccessful play or a penalty. Each action card also includes an indication of a type of movement and a direction of movement that is associated with the movement distance, the reach distance and the relative strength, and whether the type of movement is an offensive movement or a defensive movement.