Patents by Inventor Robert Mashal

Robert Mashal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY
    Publication number: 20150165021
    Abstract: Pharmaceutical compositions and treatments involving iNKT cell activation are provided.
    Type: Application
    Filed: November 5, 2014
    Publication date: June 18, 2015
    Inventors: Robert Mashal, Hans Albert Felix Scheuplein, Robert Schaub
  • Pyrazole compositions useful as inhibitors of erk
    Patent number: 7056944
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: June 6, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Publication number: 20050090536
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein, kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Application
    Filed: July 24, 2003
    Publication date: April 28, 2005
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20040102506
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 17, 2003
    Publication date: May 27, 2004
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Publication number: 20030195241
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: 1
    Type: Application
    Filed: October 15, 2002
    Publication date: October 16, 2003
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6528509
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmacuticals, Incorporated
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030040536
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 5, 2001
    Publication date: February 27, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Patent number: 6495582
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: December 17, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Publication number: 20020177618
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: 1
    Type: Application
    Filed: September 14, 2001
    Publication date: November 28, 2002
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Detection of mismatches by cleavage of nucleic acid heteroduplexes
    Patent number: 5824471
    Abstract: Novel methods and kits for detecting mismatches in nucleic acids using one or more resolvase enzymes. These methods can be used in medical procedures or research, veterinary procedures or research, agricultural applications, forensics, and paternity testing. For example, in forensics and paternity testing, methods of the invention can replace or complement RFLP mapping.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 20, 1998
    Assignees: Brigham and Women's Hospital, Dana-Farber Cancer Institute
    Inventors: Robert Mashal, Jeffrey Sklar, Richard Kolodner