Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: Example dock levelers installed at a vehicle loading dock include pivotal or otherwise vertically adjustable deck plates with special coatings on the deck's upper surface. In some examples, the coating improves traction and addresses various thermal issues, such as condensation and thermal strain between a polymeric coating and a steel deck plate. In some examples, when indoor and outdoor air create a temperature differential across opposite faces of the deck, the coating is designed such that a median temperature of the temperature differential occurs near an interface where the coating bonds to the steel plate's upper surface. In some examples, the coating includes particles of different sizes and colors embedded within and covered by a polymeric base material. As traffic abrades the coating, the different colored particles become exposed at different levels of wear, thereby providing a visual signal indicating when the coating needs to be touched up or replaced.

Abstract: Example dock levelers installed at a vehicle loading dock include pivotal or otherwise vertically adjustable deck plates with special coatings on the deck's upper surface. In some examples, the coating improves traction and addresses various thermal issues, such as condensation and thermal strain between a polymeric coating and a steel deck plate. In some examples, when indoor and outdoor air create a temperature differential across opposite faces of the deck, the coating is designed such that a median temperature of the temperature differential occurs near an interface where the coating bonds to the steel plate's upper surface. In some examples, the coating includes particles of different sizes and colors embedded within and covered by a polymeric base material. As traffic abrades the coating, the different colored particles become exposed at different levels of wear, thereby providing a visual signal indicating when the coating needs to be touched up or replaced.

Abstract: Compounds of formula (I): are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various CNS disorders.

Abstract: Compounds of formula (I) are potent and selective 5-HT2A antagonists, useful in treatment of a variety of adverse conditions of the CNS.

Abstract: A class of imidazo[1,2b][1,2,4]triazine derivatives, substituted at the 7-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having good affinity for the ?2 and/or ?3 and/or ?5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Abstract: The present invention provides a pharmaceutical composition providing a compound of formula I or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable excipient: (I), in which: X and Y independently represent CH or N, with the proviso that if X is CH then Y is also CH; R1 represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, —ORa, —SRa, —SORa, —SO2Ra, —SO2NRaRb, —NRaRb, —NRaCORb, —NRaCO2Rb, —CORa, —CO2Ra, —CONRaRb or CRa?NORb; Ra and Rb independently represent hydrogen, hydrocarbon or a heterocyclic group; V and W are independently selected from H, halogen, C11-6alkyl, OH and C-1-6alkoxy; Z represents H, halogen, CN, NO2, CF3, OCF3, CF2H, SCF3, R2, OR3, SR3, (CH2)pN(R3)2, O(CH2)pN(R3)2, SO2R2, SO2N(R3)2, COR4, CO2R3, CON(R3)2, NHCOR4, NR1(CH2)nheteroaryl or O(CH2)nheteroaryl the heteroaryl is optionally substituted by one, two or three groups chosen from C1-6alkyl, benzyl, (CH2)pN(R3)2, halogen and CF3, R1 is C1-6alkyl, where n is 1 or 2 and p is

Abstract: A gaming apparatus which comprises a slot machine capable of accepting either paper currency, p0reprinted coupons, or cash out slips. Ths slot machine also includes a printer that prints and dispenses cash out slips which include a bar code representing a unique identification that provides the amount of “winnings”. The cash out slips can be scanned into a separate currency dispenser at a Cashier's Station for receiving currency, either frm the dispenser or from an attendant. A central processing unit (CPU) generates the unique codes for retualting the game to be palyed, the wager limits of the game and the validity of the free play coupons or the cahs out tickets. The above gaming system avoids having to use coins or tokens in the operation of slot machines.

Abstract: Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.

Abstract: A gaming apparatus which comprises a slat machine capable of accepting either paper currency, preprinted coupons, or cash out slips. The slot machine also includes a printer that prints and dispenses cash out slips which include a bar code representing a unique identification that provides the amount of “winnings”. The cash out slips can be scanned into a separate currency dispenser at Cashier's Station for receiving currency, either from the dispenser or from an attendant. A central processing unit (CPU) generates the unique codes for regulating the game to be played, the wager limits of the game and the validity of the free play coupons or the cash out tickets. The above gaming system avoids having to use coins or tokens in the operation of slot machines.