Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose. The present invention also provides a novel pharmaceutical agent, (5R)-5 -(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to a process for the preparation of nitrated aromatic compounds by the mixed acid process, in which water is removed from the reaction mass by passing an inert gas through it.

Abstract: A duplex process for the mononitration of benzene wherein the nitration is carried out in an azeotropic first stage followed by a lower temperature, mixed-acid second stage. The azeotropic stage uses reaction temperatures of at least 120.degree.C in mixed HNO.sub.3 --H.sub.2 SO.sub.4, and excess water is carried overhead as an azeotrope with part of the benzene and is then decanted from the benzene. The nitrated benzene is removed as bottoms and decanted from the acid phase, avoiding the necessity of reconcentrating the H.sub.2 SO.sub.4. Both the nitrated benzene bottoms and the organic, benzene-containing part of the overhead stream are supplied to the second stage for completing the conversion into mononitrobenzene in mixed acid at lower temperatures such as 70.degree.C.