Abstract: A closure for a container having a rim surrounding an opening to be closed, the closure including a lid portion having a peripheral rim portion adapted to sealingly engage the rim of the container, and a peripheral ring portion extending from the rim portion of the lid portion and having a depending portion adapted to engage the rim of the container to hold the peripheral rim portion in sealing engagement with the container rim. The depending portion is formed with a multiplicity of separate flexible finger elements, each having an inwardly directed abutment portion which in use engages the rim of the container to hold the closure in the closed position, the fingers occupying in their as molded or neutral positions a position in which the abutment portions are in use at least partially engaged with the rim of the container.

Abstract: Biaryl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such biaryl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

Abstract: A novel transformer is described for use in a static inverter in association with one or two switching semiconductor devices. The transformer produces an output for control of the associated switching device(s) which changes in sense from conduction aiding to conduction inhibiting as a function of the flux level in the transformer core. The invention is applicable to single loop cores, such as are assembled from two "U" cores. Control is effected by a primary and secondary control winding wound through an aperture pair, the aperture pair being oriented for "neutrality" of the second control winding to the main flux. The aperture pair creates a five branch magnetic path which permits optimizing the control voltage applied to the associated semiconductor devices both to enhance the switching efficiency when the switching device is initially turned on and to reduce stresses on the switching device by precluding transformer saturation when the switching device is turned off.