Abstract: Provided herein are compositions of carbonic anhydrase and inhibitors thereof for the treatment of subjects with certain conditions such as heart disease.

Abstract: Provided herein are compositions and methods for packaging a recombinant adeno-associated vims (rAAV) particle comprising using inverted terminal repeats (ITRs) and rep genes of different serotypes and/or using chimeric rep genes.

Abstract: A tube forming apparatus for forming polymeric tubing includes a housing between rear and discharge ends. The tube forming apparatus includes a core tube assembly with an exterior core tube and an inner core tube positioned partially therein and in an interior area of the housing. The tube forming apparatus includes a die that has an inner die-surface. A diverter tip is mounted in and extends from the inner core tube into the die forming a die opening between the die and the diverter tip. The tube forming apparatus includes a core tube adjustment system mounted proximate the rear end which includes an axial displacement device configured to axially position the core tube assembly for modulating wall thickness of the tube and/or an angular displacement device configured to modulate the inner core tube for modulating concentricity of the tube.

Abstract: Disclosed herein are chimeric recombinant adeno-associated virus (rAAV) capsid proteins comprising a region of VP1? that is replaced by the corresponding amino acids of the VP1? of AAV serotype 1 (AAV1) or AAV serotype 8 (AAV8), and particles comprising them.

Abstract: Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.

Abstract: A tube forming apparatus for forming polymeric tubing includes a housing between rear and discharge ends. The tube forming apparatus includes a core tube assembly with an exterior core tube and an inner core tube positioned partially therein and in an interior area of the housing. The tube forming apparatus includes a die that has an inner die-surface. A diverter tip is mounted in and extends from the inner core tube into the die forming a die opening between the die and the diverter tip. The tube forming apparatus includes a core tube adjustment system mounted proximate the rear end which includes an axial displacement device configured to axially position the core tube assembly for modulating wall thickness of the tube and/or an angular displacement device configured to modulate the inner core tube for modulating concentricity of the tube.

Abstract: This disclosure relates to variant AAV6 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.

Abstract: Provided herein are compositions and methods for packaging a recombinant adeno-associated virus (rAAV) particle comprising using inverted terminal repeats (ITRs) and rep genes of different serotypes and/or using chimeric rep genes.

Abstract: Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.

Abstract: A treadmill lubrication system and method is provided. In a preferred embodiment, the lubrication system comprises a spray bottle with a nozzle including an extended tube through which a silicone-based lubricant may be sprayed. The extended tube of the nozzle is designed to be inserted underneath the belt of a treadmill with the tube having a length sufficient to reach the treadmill components that require lubrication. The extended tube is preferably constructed from a material that provides enough rigidity to prevent significant bending and/or kinking of the tube, while still allowing for enough flexibility that the tube can be inserted underneath the belt of a treadmill without breaking or snapping in half.

Abstract: Disclosed herein are modified carbonic anhydrase enzymes, and a process of using same for the extraction, production and purification of carbon dioxide gas. More particularly, modified carbonic anhydrase enzymes are used for the production, purification of carbon dioxide and the products of the hydration reaction, hydrogen and bicarbonate ions Also, this technology is used to enhance the production of carbon dioxide in blood or in reverse osmosis desalination to remove carbon dioxide. Specifically, the invention relates to a modified carbonic anhydrase enzyme possessing improved activity and a process whereby immobilized modified carbonic anhydrase contained within a reactor device catalyzes the reversible hydration of carbon dioxide.

Abstract: Disclosed herein are modified carbonic anhydrase enzymes, and a process of using same for the extraction, production and purification of carbon dioxide gas. More particularly, modified carbonic anhydrase enzymes are used for the production, purification of carbon dioxide and the products of the hydration reaction, hydrogen and bicarbonate ions Also, this technology is used to enhance the production of carbon dioxide in blood or in reverse osmosis desalination to remove carbon dioxide. Specifically, the invention relates to a modified carbonic anhydrase enzyme possessing improved activity and a process whereby immobilized modified carbonic anhydrase contained within a reactor device catalyzes the reversible hydration of carbon dioxide.

Abstract: A suture has a fluid delivery line for improved retention of a suture line. The suture includes a suture body including a central lumen. The suture body further includes an inner surface along the central lumen and an exterior surface. Spaced perforations are formed along the suture body for maintaining the lumen in fluid communication with the exterior surface of the suture body. When fluid is pumped into the suture, the perforations allow the fluid to be distributed along the length of the exterior surface of the suture body both internal and external to the opposed tissue secured by the suture.

Abstract: A surgical instrument comprises a handle connected to a shaft and a pair of inflatable members. The shaft includes conduits for communicating a pressurized medium to the inflatable members and an insufflation tube. The handle includes a port for communicating a pressurized medium to the conduits and a port for communicating a pressurized medium to the insufflation tube. After an anastomotic ring has been deployed, the shaft may be positioned such that an inflatable member is positioned within each of the lumens joined by the anastomosis, such that an inflatable member is located on each side of the anastomosis. The inflatable members may be inflated to provide a seal in each of the lumens. With each of the lumens sealed by the inflatable members, the anastomosis site may be insufflated through the insufflation tube to leak or pressure test the anastomosis.

Abstract: A surgical tool or applier facilitates laparoscopic or endoscopic implantation through a single bodily tissue lumen of an anastomotic ring device for forming a hollow rivet type of attachment between tissue lumens. In addition to forming a puncture between apposite tissue walls at the anastomosis site, the applier assists or wholly actuates the anastomotic ring device and is retracted to deploy the actuated ring device. Illumination incorporated into a distal portion of a cannula enables confirmation of deployment.

Abstract: A method and apparatus to facilitate nutritional malabsorption by diverting digestive secretions, such as bile or pancreatic secretions. A tube is positioned substantially within the small intestine. The tube comprises a proximal end which when deployed is operative to receive digestive secretions, a distal end which when deployed is operative to discharge the digestive secretions into the alimentary tract, and a tube wall having an inner surface and an outer surface, the tube wall inner surface defining passage extending between the proximal and distal ends. When deployed the passage is operative to transfer the digestive secretions from the proximal end to the distal end thereby reducing digestive contact between the digestive secretions and food in the small intestine.

Abstract: The present invention includes methods and materials for manipulating the sense of satiety developed from the gastrointestinal transit of a substance in a mammal, whether the substance be a food or drug compound. The method involves administering a therapeutically effective amount, by a direct delivery route, of a pharmaceutically acceptable formulation comprising nutrients and pharmacological agents to the mammal's gastrointestinal tract. The present system is designed to maximize satiety feedback from normal intestinal sensors by small amounts of nutrients or nutrient derivatives, in essence, to “fool” body sensors that are not usually in contact with nutrients unless very large amounts are ingested.

Abstract: A method of separating wafers, such as those used for semiconductor device manufacture, into die. A partly fabricated wafer is covered with a protective coating over its top surface (10). The wafer is then inscribed to define separation lines between die, with the separation lines being of a predetermined depth (12). The protective coating is then removed (14), and at least one processing step is performed at the wafer level (15, 22-24), before the inscribed wafer is separated into die. Then, the wafer is separated into die along the separation lines (17).