Abstract: A fishing bait holding system includes a housing has a bottom wall and a perimeter wall that is attached to and extends upwardly from the bottom wall. The perimeter wall has an upper edge defining an opening into the housing and the perimeter wall includes a front wall, a rear wall, a first side wall and a second side wall. The housing is water impermeable and holds a quantity of fishing bait. A lid is hingedly coupled to the housing and the lid is positioned in closed position abutting the upper edge or positioned in an open position allowing access to the interior of the housing. A coupler is attached to the housing. The coupler releasably secures the housing to a barrier.

Abstract: The present invention provides a method for treating cancer by promoting apoptosis and reducing clonogenic survival of cancer cells. The method encompasses co-administering 1) a cell cycle checkpoint abrogation agent (for example, UCN-01 or caffeine) and 2) an inhibitor of a compensatory cytoprotective pathway, such as an agent that inhibits the MEK 1/2 pathway (e.g. PD98059, U0126, or PD184352) or an agent that inhibits the PI 3 pathway (e.g. LIY294002 or wortmanin). In addition, because the co-administration step also radiosensitizes cancer cells, the method additionally encompasses the administration of radiation to further reduce clonogenic survival of cancer cells. The method promotes apoptosis and reduces clonogenic survival in many types of cancer cells, including leukemia cells, prostate cancer cells, breast cancer cells, myeloma cells, and lymphoma cells.