Abstract: Apparatus and methods for modeling an optical system in order to predict the behavior of tightly focused light in a turbulent medium. A model of an optical device in the system and a model of the index of refraction in a sample are provided. Then the electric fields just before and at the turbulent medium are determined. Next the system propagates the electric field into the medium by small steps using a finite difference version of a wave equation for two most recent fields, starting with the fields before and at the sample. Propagation is continued until a desired area is reached.

Abstract: The present disclosure relates to the field of pharmaceutical preparations, dosage regimens, and administration of an antibody-drug conjugate (ADC). More specifically, the ADC is composed of an anti-cadherin-6 (CDH6) antibody connected via a linker to an anticancer agent, such as topoisomerase I inhibitor.

Abstract: A locking system in an industrial machine is provided. The locking system includes a lock-ring positioned in a lock-ring recess in a rotational shaft, a spacing plate axially interfacing with the lock-ring, and a compression plate with a threaded opening. The locking system further includes a bolt threadingly engaged with the threaded opening in the compression plate and a spring axially interposed between the spacing plate and the compression plate.

Abstract: Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly (methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate.

Abstract: The present invention relates to the unexpected discovery of 3D printed biomimetics of growth plate cartilage and methods using the same for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of bony bars at the site of growth plate injury, thereby preventing growth arrest and/or deformity.

Abstract: A locking system in an industrial machine is provided. The locking system includes a lock-ring positioned in a lock-ring recess in a rotational shaft, a spacing plate axially interfacing with the lock-ring, and a compression plate with a threaded opening. The locking system further includes a bolt threadingly engaged with the threaded opening in the compression plate and a spring axially interposed between the spacing plate and the compression plate.

Abstract: Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly (methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate.

Abstract: The present invention relates to the unexpected discovery of 3D printed biomimetics of growth plate cartilage and methods using the same for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of bony bars at the site of growth plate injury, thereby preventing growth arrest and/or deformity.

Abstract: A system includes a resonant sensor in contact with oil within a gearbox of a rotor system, such as a wind turbine, and one or more processors. The sensor includes electrodes and a sensing circuit that generates electrical stimuli having frequencies applied to the oil at different times during a life of the gearbox. The processors receive electrical signals from the resonant sensor representative of impedance responses of the oil to the electrical stimuli. The processors analyze the impedance responses and determine a concentration of a polar analyte in the oil at different times. The processors calculate a degradation value for the gearbox based on the concentration of the polar analyte. Responsive to the degradation value exceeding a designated threshold, the processors at least one of schedule maintenance for the rotor system, provide an alert to schedule maintenance, or prohibit operation of the rotor system until maintenance is performed.

Abstract: A system includes a resonant sensor in contact with oil within a gearbox of a rotor system, such as a wind turbine, and one or more processors. The sensor includes electrodes and a sensing circuit that generates electrical stimuli having frequencies applied to the oil at different times during a life of the gearbox. The processors receive electrical signals from the resonant sensor representative of impedance responses of the oil to the electrical stimuli. The processors analyze the impedance responses and determine a concentration of a polar analyte in the oil at different times. The processors calculate a degradation value for the gearbox based on the concentration of the polar analyte. Responsive to the degradation value exceeding a designated threshold, the processors at least one of schedule maintenance for the rotor system, provide an alert to schedule maintenance, or prohibit operation of the rotor system until maintenance is performed.

Abstract: Interferometric path length measurements using frequency-domain interferometry form the basis of several measurement techniques, including optical frequency domain reflectometry (OFDR), optical coherence tomography (OCT), and frequency-modulated continuous wave (FMCW) radar and lidar. A phase-sensitive and self-referenced approach to frequency-domain interferometry yields absolute and relative path length measurements with axial precision orders of magnitude better than the transform-limited axial resolution of the system.

Abstract: Interferometric path length measurements using frequency-domain interferometry form the basis of several measurement techniques, including optical frequency domain reflectometry (OFDR), optical coherence tomography (OCT), and frequency-modulated continuous wave (FMCW) radar and lidar. A phase-sensitive and self-referenced approach to frequency-domain interferometry yields absolute and relative path length measurements with axial precision orders of magnitude better than the transform-limited axial resolution of the system.

Abstract: An apparatus for application of a liquid manure to soil, possessing a frame which is adapted when towed over soil to apply such to the soil. A supply conduit, having a distal end and a proximal end is provided. The distal end thereof is adapted to be releasibly coupled and in fluid communication with a flexible supply hose which supplies the liquid-solid solution, such as liquid manure, to the distal end of the conduit. The proximal end of the conduit is in fluid communication with a manifold which thereafter via a plurality of supply tubes supplies such liquid/liquid solid dispersion to the soil. An intermediate portion of the supply conduit is flexible. A boom member at its distal end supports a distal end of the supply conduit. A proximal end of the boom member is pivotably coupled to the frame to allow pivotal movement of the distal end of the boom member in at least a horizontal plane.

Abstract: Apparatus for applying liquid-solid dispersions to soil. Valve means are provided which permit cleaning. An elongate conduit, with an aperture at one end, and a first valve proximate such aperture may be opened to permit passage of a pig member. An upwardly extending conduit is “T'ed” off the elongate conduit, and connects with a manifold and a plurality of supply tubes to direct the liquid-solid dispersions to the soil at various points along the frame of the applicator. A second valve may be provided on the upwardly extending conduit, which may be closed to prevent initial supply of the liquid-solid dispersion to the apparatus and instead flow to the aperture to prevent plugging during initial operation. The second valve, when closed, further serves as an anti-siphoning valve to prohibit further supply of liquid solid dispersion to the manifold. A method for cleaning such apparatus is further disclosed.

Abstract: A waveguide array is fabricated by providing a photoreactive material and generating an optical intensity pattern corresponding to a geometry of the waveguide array. A relative translation of the photoreactive material is effected through the optical intensity pattern. Thereafter, the photoreactive material is rendered substantially unreactive to light at at least a wavelength of the optical intensity pattern.

Abstract: Disclosed is an article having a surface-relief holographic recording medium having digital data that cannot be seen by human eye. Also disclosed is a tilted-plane optical reader system which can be used to read the stored data in the hologram.

Abstract: An apparatus for application of a liquid or liquid-solid dispersion to soil, which is adapted when towed over soil to apply such liquid-solid dispersion to the soil. A supply conduit, having a distal end and a proximal end is provided. The distal end thereof is adapted to be releasibly coupled and in fluid communication with a source of liquid-solid solution, such as liquid manure. The supply conduit is pivotally coupled, via a pivot member, to the frame of the implement to permit the supply conduit to be pivoted in a substantially horizontal plane. The pivot member is coupled at one end thereof to the supply conduit at a location intermediate the distal end and the proximal end of such supply conduit, and is pivotally coupled at an opposite end to the frame of the apparatus. A manifold portion, having a plurality of manifolds thereon, is provided.

Abstract: Disclosed is an article having a holographic recording medium having digital data that cannot be seen by human eye, wherein the holographic recording medium is a holographic material that records volume holograms that permit authentication of the article and the holographic material is attached to or part of the article. Also disclosed is a method of authentication of the article.

Abstract: An apparatus for monitoring an input optical signal at a plurality of distinct optical frequencies is disclosed wherein a demultiplexing arrayed waveguide grating (AWG) having a plurality of M>1 Vernier input ports is disposed between an optical switch and a photodiode array coupled to the output ports of the AWG. In operation, the optical switch sequentially provides the input optical signal into each of the Vernier ports, and signals detected by photodiodes are stored in a memory unit. The apparatus is capable of monitoring the input optical signal with a frequency step which is M times smaller than a frequency spacing between the AWG transmission bands, and obtain M frequency-resolved readings from each photodiode.