Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured ASIC formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured ASIC connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured ASIC formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured ASIC connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured ASIC formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured ASIC connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. In various instances, each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform one or more steps a variant call operation.

Abstract: A “dynamic” reference is presented that utilizes population level information to improve reference-based alignment to detect novel, deleterious, or functional variants in clinical sequencing applications. An automatically updated database of known genetic variants is provided to a memory connected with an integrated circuit configured for genetic sequence data with the dynamic reference and reference variants.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A “dynamic” reference is presented that utilizes population level information to improve reference-based alignment to detect novel, deleterious, or functional variants in clinical sequencing applications. An automatically updated database of known genetic variants is provided to a memory connected with an integrated circuit configured for genetic sequence data with the dynamic reference and reference variants.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.

Abstract: Disclosed is a method and system for capturing and reporting information relating to an organization's queries, such as Internet search queries generated by particular groups within an organization, and making such information available to others to support various decisions organizations must make. The search activity of search-level users may be constantly tracked, and search event data records (including query terms and an identification of the search-level user) are collected and analyzed. An analytics engine receives and analyzes the search event data and determines when predefined organization-specific relationships exist between queries of distinct users.

Abstract: The invention is a head rest actuation system which is activated by forces acting upon a seat back or devices within a seat back. Forces acting upon a seat back or lumbar devices within a seat back are transmitted to a head rest and provide and actuating force therefor.

Abstract: A four way lumbar support for an automobile seat includes a wire array (16), a fixed frame (20), and a basculating arm. When in its extruded position, the basculating arm (50) exerts pressure on the wire array (16) thus providing lumbar support to the seat occupant at that point. A system of Bowden cables and sliding connections allows the basculating arm to slide vertically along the fixed frame so that the lumbar support may be provided at different heights within the seat.

Abstract: A seat back cushion support presenting device for use in a foldable vehicle seat moves a cushion support member from a position within the seat back frame to a position extended from the seat back frame such that the entire cushion is presented. A pair of presenting members, each including a side bolster support portion, are provided in overlapping arrangement for translation along a presenting device support member and rotation with respect to a cushion support member such that as an activation member moves the presenting members together, the cushion support member is extended along with the side bolster support portions.

Abstract: A hollow axle motor assembly (10) includes an armature (13) and a hollow axle (12) attached to the armature (13). The hollow axle (12) has an outer diameter (14) and an inner diameter (16). The inner diameter (16) of the hollow axle (12) receives a shaft or tube, such as a drive shaft (52). A gear (20) is attached to the outer diameter (14) of the hollow axle (12). The gear (20) is in driving communication with a planetary gear drive assembly (30). In turn, the planetary gear drive assembly (30) is in driving communication with a drive shaft mount (40). The drive shaft mount (40) can be used to drive any number of conventional items, including, for example, the drive shaft (52).

Abstract: A seat support includes a lumbar, a foam pad, trim wires, and an actuator. The lumbar is supported by and actuated between trim wires which are embedded within the seat's foam pad. The actuator is connected to and adjusts the lumbar relative to the foam pad. The foam pad preferably includes passages through which fasteners can extend between the lumbar to the trim wires.

Abstract: An ergonomic device for a seat is disclosed. The ergonomic device includes a first side plate and a second side plate spaced apart from the first side plate. A hinge connects the second side plate to the first side plate. The ergonomic device also includes at least one pulley connected to the first side plate or the second side plate. A traction element is connected to at least one of the side plates, and the traction element has a cable wire generally wrapped about the at least one pulley. The traction element engages the pulley to at least partially collapse the hinge when a tractive force is applied to the traction element.

Abstract: A configurable vehicle seat having at least two configurations is disclosed. The configurable vehicle seat has a seat base, a seat bottom supported by the seat base, and a seat back coupled to the seat base. The seat back or seat bottom has one or more adjustable profile members, wherein the adjustable profile members may be adjusted such that the seat is adjusted from at least a first configuration to a second configuration.