Abstract: A system includes a processing device, operatively coupled to memory, to obtain one or more ciphers that are supported by a device that is coupled to a network, determine, by the processing device, a value associated with the device, based on whether each of the one or more ciphers that are supported by the device is quantum-safe, and generate a notification based on the value.

Abstract: A system includes a processing device, operatively coupled to memory, to obtain one or more ciphers that are supported by a device that is coupled to a network, determine, by the processing device, a value associated with the device, based on whether each of the one or more ciphers that are supported by the device is quantum-safe, and generate a notification based on the value.

Abstract: A system for identifying and tracking a plurality of implant devices. The system includes at least one communication device and a medical implant device tracking system. The medical implant device tracking system includes a processor on which is installed an implant device tracking application. The implant device tracking application enables the communication device to scan a unique device identifier (UDI) of the implant devices thereby recording a complete and accurate set of information about the implant devices. The medical implant device tracking system includes a database unit, an implant manufacturer access unit, a hospital access unit, a patient access unit, and a physician access unit. The implant device tracking application generates immediate notification of the recall status of the at least one implant device at the time of the implant device scanning thereby preventing the implantation of the recalled implant device in the patient's body.

Abstract: Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.

Abstract: Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.

Abstract: An assembly including a device for dilating a vessel or a structure (such as a stent or stent graft) within a vessel wherein the device comprises a plurality of wires that are spaced apart when the device is dilated so as to allow fluid to flow through the device. Thus, when in use the device does not occlude or substantially hinder the flow of blood through a vessel or into side vessels. The device may also be flexible enough to be easily maneuvered through tight bends in a vessel and/or be able to conform to varying diameters within a single vessel or within multiple vessels.

Abstract: A device for dilating a vessel or a structure (such as a stent or stent graft) within a vessel comprises a plurality of wires that are spaced apart when the device is dilated so as to allow fluid to flow through the device. Thus, when in use the device does not occlude or substantially hinder the flow of blood through a vessel or into side vessels.

Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.

Abstract: The present invention provides a system for directing a first guidewire in a retrograde direction in a blood vessel and for directing a second guidewire in an antegrade direction in a blood vessel. The system includes a dual-lumen obturator having a first lumen leading to a first obturator opening and a second lumen leading to a second obturator opening, and a sheath having a first end having a first sheath opening, a second end having a second opening, a sheath lumen extending from the first end to the second end, and a third sheath opening between the first end and the second end. The first, second, and third sheath openings are in communication with the lumen. A first guidewire is directed through the first lumen and through the second sheath opening in a retrograde direction in the blood vessel, while a second guidewire is directed through the second lumen and through the third sheath opening in an antegrade direction in a blood vessel.

Abstract: A device for dilating either a vessel within a body or a structure positioned within the vessel is designed so that it does not occlude or substantially hinder the flow of blood through the vessel, thereby decreasing the windsock effect in blood vessels by maintaining fluid flow through the device during dilation. The device includes a plurality of wires that can be expanded from a first position wherein the device can be moved into or retrieved from the vessel, to a second position wherein it dilates the vessel or structure. When dilated, blood or other bodily fluid passes through the openings between the wires rather than being blocked.

Abstract: The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

Abstract: A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.