Abstract: A method of generating an antibody and cellular immune response against a Plasmodium in a primate, comprising administering at least 103 genetically modified live Plasmodium to the primate, wherein the genetically modified live Plasmodium is a species selected from Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, Plasmodium knowlesi, Plasmodium coatneyi, Plasmodium cynomolgi, and Plasmodium simium, and wherein the genetically modified live Plasmodium does not produce functional histamine releasing factor (HRF) protein, to thereby induce an antibody and cellular immune response against the Plasmodium in the primate. In some embodiments at least 104 genetically modified live Plasmodium is administered to the primate.

Abstract: A method of generating an antibody and cellular immune response against a Plasmodium in a primate, comprising administering at least 103 genetically modified live Plasmodium to the primate, wherein the genetically modified live Plasmodium is a species selected from Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, Plasmodium knowlesi, Plasmodium coatneyi, Plasmodium cynomolgi, and Plasmodium simium, and wherein the genetically modified live Plasmodium does not produce functional histamine releasing factor (HRF) protein, to thereby induce an antibody and cellular immune response against the Plasmodium in the primate. In some embodiments at least 104 genetically modified live Plasmodium is administered to the primate.

Abstract: A method of generating an antibody and cellular immune response against a Plasmodium in a primate, comprising administering at least 103 genetically modified live Plasmodium to the primate, wherein the genetically modified live Plasmodium is a species selected from Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, Plasmodium knowlesi, Plasmodium coatneyi, Plasmodium cynomolgi, and Plasmodium simium, and wherein the genetically modified live Plasmodium does not produce functional histamine releasing factor (HRF) protein, to thereby induce an antibody and cellular immune response against the Plasmodium in the primate. In some embodiments at least 104 genetically modified live Plasmodium is administered to the primate.

Abstract: A computer device is provided that includes an input device, a sensor device, a display device, and a processor. The processor is configured to detect a physical object in a physical environment based on sensor data received via the sensor device, measure one or more physical parameters of the physical object based on the sensor data, determine a physical behavior of the physical object based on the measured one or more physical parameters, present a graphical representation of the physical behavior of the physical object via the display device, generate a simulation of the physical behavior of the physical object based on the measured one or more physical parameters, receive a user input to modify the one or more physical parameters for the simulation via the input device, and present the simulation with the modified one or more physical parameters via the display device.

Abstract: A computer device is provided that includes an input device, a sensor device, a display device, and a processor. The processor is configured to detect a physical object in a physical environment based on sensor data received via the sensor device, measure one or more physical parameters of the physical object based on the sensor data, determine a physical behavior of the physical object based on the measured one or more physical parameters, present a graphical representation of the physical behavior of the physical object via the display device, generate a simulation of the physical behavior of the physical object based on the measured one or more physical parameters, receive a user input to modify the one or more physical parameters for the simulation via the input device, and present the simulation with the modified one or more physical parameters via the display device.

Abstract: A method of generating an antibody and cellular immune response against a Plasmodium in a primate, comprising administering at least 103 genetically modified live Plasmodium to the primate, wherein the genetically modified live Plasmodium is a species selected from Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, Plasmodium knowlesi, Plasmodium coatneyi, Plasmodium cynomolgi, and Plasmodium simium, and wherein the genetically modified live Plasmodium does not produce functional histamine releasing factor (HRF) protein, to thereby induce an antibody and cellular immune response against the Plasmodium in the primate. In some embodiments at least 104 genetically modified live Plasmodium is administered to the primate.

Abstract: Methods and systems for locating a vehicle are disclosed, including detecting one or more environmental conditions, the one or more environmental conditions being indicative of an occurrence of an environmental event, determining a probability of the occurrence of the environmental event in response to detecting the one or more environmental conditions, and effecting a preventive action in response to the probability being above a threshold probability, the preventive action being configured to protect the vehicle from the environmental event.

Abstract: The present invention relates to novel compositions and methods for immunizing a host against malaria using a Plasmodium parasite genetically attenuated via the inactivation of the function of the hmgb2 gene.

Abstract: Methods and systems for locating a vehicle are disclosed, including detecting one or more environmental conditions, the one or more environmental conditions being indicative of an occurrence of an environmental event, determining a probability of the occurrence of the environmental event in response to detecting the one or more environmental conditions, and effecting a preventive action in response to the probability being above a threshold probability, the preventive action being configured to protect the vehicle from the environmental event.

Abstract: A sensor system for protecting a door of a vehicle from damage includes an electronic sensor operable to detect when an object external to the vehicle is within close proximity to the door of the vehicle. The sensor system provides a signal indicative of the proximity of the external object. The sensor system also includes a blocking hinge mechanism coupled with the signal. The hinge mechanism blocks the opening of the door beyond a distance wherein the vehicle door would strike the object.

Abstract: There is provided a method of detecting protease activity in an intracellular region of a cell. The method comprises: obtaining a reporter protein having a site susceptible to cleavage by the protease of interest in the intracellular region, introducing the reporter protein into the intracellular region, and assaying the effect on reporter activity observed following its entry into the intracellular region. Also provided are protein and nucleotide sequences useful in carrying out the method. Of particular interest are protein and nucleotide sequences relating to mutant forms of Green Fluorescent Protein that are useful as a reporter protein in the intracellular protease assay.

Abstract: A method of detecting video sequences involves creating on-the-fly candidate digital signatures uniquely characteristic of successive groups of frames in accordance with a predetermined algorithm. The candidate digital signatures are compared with at least one signature of a stored sequence created in accordance with the predetermined algorithm. A candidate is identified as corresponding to the stored sequence in the event of a positive match.

Abstract: A system for monitoring standard broadcast signals, comprises a device for receiving the broadcast signals, a user-operable selection device for inputting criteria identifying program content of interest to the user, a database for storing data representing the criteria, and a recognition device for generating from the broadcast signals a program data stream representative of the program content. A comparator for compares the program data with the stored data, and an output device carries out a predetermined action, such recording a segment of the program, when the program data matches the stored data. The system will, for example, activate a window on a multimedia PC when preselected program material is present in the broadcast signals.

Abstract: Novel 6-substituted amino-4-oxa-1-azabicyclo?3,2,0!heptan-7-one compounds, as well as the pharmaceutically acceptable salts thereof and diastereoisomers thereof, of formula I, ##STR1## are disclosed, which exhibit excellent cysteine protease inhibitory activity and may be used for treatment of different diseases such as muscular dystrophy, arthritis, myocardial infarction, Alzheimer's disease, bacterial infection, common cold, osteroporosis and cancer metastasis.