Abstract: A laser photo optic breakdown probe and handpiece system especially suited for small-incision cataract removal including an optical fiber through which a pulsed source of laser energy is delivered to a target spaced from the distal end of the fiber. The fiber is routed through a first guide tube with the target mounted at an angle on the end thereof. Holes are provided in the guide tube for the flow of infusion fluid therethrough. A second aspiration tube surrounds and provides rigidity to the guide tube, shields the distal end of the fiber and target, and serves as a channel for aspirated fluids and dislodged cataractous material. The guide tube is affixed to a transfer housing to which infusion and aspiration connections are made. The aspiration tube forms part of a handle assembly which is detachably coupled to the transfer housing.