Abstract: Particular aspects of the present invention provide novel systems and methods for method for epidemiological and environmental monitoring and assessment, and for active management of human health hazards associated with building environments. In particular aspects, the inventive system and methods are used as a human health and environmental health management tool for corporations (e.g., offices, factories), commercial buildings, condominiums, hotels, resorts, camps, military installations, schools, daycares, cruise ships, real estate developments, towns and cities, prisons, or any other institutional or community settings. In particular aspects, the inventive system and methods are used in a proactive manner to maintain the health of building occupants. Additional aspects provide systems and methods having substantial utility as an investigative tool to substantiate human health claims and correlate underlying environmental factors.